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Apellis Pharmaceuticals Inc stock is traded at $20.33, with a volume of 5.58M. It is down -4.69% in the last 24 hours and down -19.42% over the past month. Apellis Pharmaceuticals Inc is a commercial-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system, which is an integral component of the immune system, at the level of C3, the central protein in the complement cascade.
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Previous Close:
$21.33
Open:
$21.29
24h Volume:
5.58M
Relative Volume:
2.06
Market Cap:
$2.57B
Revenue:
$715.22M
Net Income/Loss:
$-250.10M
P/E Ratio:
-10.01
EPS:
-2.03
Net Cash Flow:
$-205.58M
1W Performance:
-23.25%
1M Performance:
-19.42%
6M Performance:
+2.11%
1Y Performance:
-26.58%
1-Day Range:
Value
$20.03
$21.29
1-Week Range:
Value
$20.03
$27.46
52-Week Range:
Value
$16.10
$31.17

Apellis Pharmaceuticals Inc Stock (APLS) Company Profile

Name
Name
Apellis Pharmaceuticals Inc
Name
Phone
617-977-5700
Name
Address
100 FIFTH AVENUE, WALTHAM, KY
Name
Employee
710
Name
Twitter
@ApellisPharma
Name
Next Earnings Date
2024-12-05
Name
Latest SEC Filings
Name
APLS's Discussions on Twitter

Compare APLS with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
APLS
Apellis Pharmaceuticals Inc
20.33 2.70B 715.22M -250.10M -205.58M -2.03
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
449.53 115.36B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
754.14 79.76B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ARGX
Argen X Se Adr
799.33 50.16B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
366.86 48.88B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
346.75 38.85B 4.98B 69.59M 525.67M 0.5197

Apellis Pharmaceuticals Inc Stock (APLS) Upgrades & Downgrades

Date Action Analyst Rating Change
Nov-06-25 Initiated Wolfe Research Peer Perform
Oct-15-25 Initiated Wells Fargo Overweight
Sep-26-25 Downgrade Goldman Neutral → Sell
May-09-25 Downgrade BofA Securities Buy → Neutral
May-09-25 Downgrade Raymond James Strong Buy → Outperform
Apr-29-25 Initiated Cantor Fitzgerald Overweight
Dec-17-24 Downgrade Goldman Buy → Neutral
Nov-21-24 Initiated Morgan Stanley Equal-Weight
Oct-25-24 Initiated RBC Capital Mkts Sector Perform
Oct-16-24 Initiated Scotiabank Sector Outperform
Oct-16-24 Initiated William Blair Outperform
May-31-24 Initiated Piper Sandler Neutral
Feb-05-24 Upgrade Jefferies Hold → Buy
Dec-14-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-09-23 Initiated Goldman Buy
Nov-02-23 Initiated Mizuho Neutral
Oct-06-23 Upgrade JP Morgan Neutral → Overweight
Sep-15-23 Upgrade Wells Fargo Equal Weight → Overweight
Aug-29-23 Reiterated Citigroup Buy
Aug-03-23 Downgrade JP Morgan Overweight → Neutral
Aug-01-23 Downgrade BofA Securities Buy → Neutral
Jan-03-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-10-22 Downgrade Jefferies Buy → Hold
Jul-19-22 Initiated H.C. Wainwright Buy
Jun-17-22 Resumed Stifel Buy
Apr-14-22 Downgrade ROTH Capital Neutral → Sell
Dec-08-21 Initiated Wells Fargo Overweight
Nov-29-21 Downgrade ROTH Capital Buy → Neutral
Sep-10-21 Reiterated BMO Capital Markets Outperform
Sep-10-21 Reiterated Credit Suisse Neutral
Sep-10-21 Reiterated Needham Buy
Sep-10-21 Reiterated Oppenheimer Outperform
Sep-10-21 Downgrade Wedbush Outperform → Neutral
Aug-19-21 Initiated Jefferies Buy
Aug-19-21 Upgrade Wedbush Neutral → Outperform
May-21-21 Initiated UBS Buy
Apr-16-21 Initiated Goldman Buy
Nov-19-20 Initiated Needham Buy
Sep-01-20 Initiated Stifel Buy
Jul-20-20 Initiated ROTH Capital Buy
Jun-17-20 Initiated BTIG Research Neutral
Apr-01-20 Initiated Raymond James Strong Buy
Mar-31-20 Initiated BMO Capital Markets Outperform
Mar-11-20 Upgrade Wedbush Underperform → Neutral
Jan-07-20 Initiated SVB Leerink Mkt Perform
Dec-19-19 Initiated BofA/Merrill Buy
Nov-22-19 Initiated Wedbush Underperform
Nov-05-19 Initiated Credit Suisse Neutral
Aug-01-19 Reiterated Cantor Fitzgerald Overweight
Jul-12-19 Upgrade JP Morgan Neutral → Overweight
Mar-29-19 Initiated Robert W. Baird Outperform
Jan-23-19 Downgrade JP Morgan Overweight → Neutral
Jul-30-18 Upgrade B. Riley FBR Neutral → Buy
May-24-18 Initiated Cantor Fitzgerald Overweight
Apr-12-18 Downgrade B. Riley FBR, Inc. Buy → Neutral
Feb-08-18 Initiated B. Riley FBR, Inc. Buy
View All

Apellis Pharmaceuticals Inc Stock (APLS) Latest News

pulisher
Jan 14, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Stock Price Down 5.8% on Analyst Downgrade - MarketBeat

Jan 14, 2026
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Jan 14, 2026

Apellis Pharmaceuticals Target of Unusually Large Options Trading (NASDAQ:APLS) - MarketBeat

Jan 14, 2026
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Jan 14, 2026

Apellis Pharmaceuticals (APLS) Reports Q1 Earnings: What Key Metrics Have to Say - sharewise.com

Jan 14, 2026
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Jan 13, 2026

Rising SYFOVRE Demand and Prefilled Syringe Plan Could Be A Game Changer For Apellis Pharmaceuticals (APLS) - Yahoo Finance

Jan 13, 2026
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Jan 13, 2026

Silver Jumps To $89 After Soft CPI, JPMorgan Falls 3%: What's Moving Markets Tuesday? - Benzinga

Jan 13, 2026
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Jan 13, 2026

APLS: Cantor Fitzgerald Lowers Price Target, Maintains Overweigh - GuruFocus

Jan 13, 2026
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Jan 13, 2026

Cantor Fitzgerald Lowers Apellis Pharmaceuticals (NASDAQ:APLS) Price Target to $35.00 - MarketBeat

Jan 13, 2026
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Jan 13, 2026

Forecasting The Future: 9 Analyst Projections For Apellis Pharmaceuticals - Benzinga

Jan 13, 2026
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Jan 13, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Price Target Cut to $28.00 by Analysts at Needham & Company LLC - MarketBeat

Jan 13, 2026
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Jan 13, 2026

Cantor Fitzgerald reiterates Overweight rating on Apellis stock, lowers price target - Investing.com UK

Jan 13, 2026
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Jan 13, 2026

Five Below To Rally Around 18%? Here Are 10 Top Analyst Forecasts For Tuesday - Benzinga

Jan 13, 2026
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Jan 13, 2026

APLS: Needham Maintains Buy Rating, Lowers Price Target to $28 | - GuruFocus

Jan 13, 2026
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Jan 13, 2026

A Look At Apellis Pharmaceuticals (APLS) Valuation After Strong 2025 Revenue Update And Nephrology Expansion - Yahoo Finance

Jan 13, 2026
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Jan 13, 2026

Apellis Pharmaceuticals (APLS) Stock Analysis: A 50% Upside Potential in the Biotech Sector - DirectorsTalk Interviews

Jan 13, 2026
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Jan 12, 2026

Apellis Pharmaceuticals Reports Preliminary 2025 Financial Results and Strategic Updates - TradingView — Track All Markets

Jan 12, 2026
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Jan 12, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Shares Gap DownHere's What Happened - MarketBeat

Jan 12, 2026
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Jan 12, 2026

Apellis Pharmaceuticals Details Syfovre Growth, Prefilled Syringe Filing at JPM Healthcare Conference - MarketBeat

Jan 12, 2026
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Jan 12, 2026

Apellis (APLS) stock slides 15% after $689 mln 2025 revenue preview at JPM conference - TechStock²

Jan 12, 2026
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Jan 12, 2026

Goldman Sachs reiterates Sell rating on Apellis stock amid revenue miss - Investing.com Canada

Jan 12, 2026
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Jan 12, 2026

Apellis (APLS) Shares Plummet Over 17% - GuruFocus

Jan 12, 2026
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Jan 12, 2026

Apellis Pharmaceuticals Reports Preliminary 2025 Revenues of $689 Million, Highlights Growth in SYFOVRE and EMPAVELI Sales - Quiver Quantitative

Jan 12, 2026
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Jan 12, 2026

Apellis Pharmaceuticals Shows Improved Relative Strength; Still Shy Of Benchmark - Investor's Business Daily

Jan 12, 2026
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Jan 09, 2026

Why (APLS) Price Action Is Critical for Tactical Trading - Stock Traders Daily

Jan 09, 2026
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Jan 09, 2026

Should You Be Concerned About Apellis Pharmaceuticals, Inc.'s (NASDAQ:APLS) ROE? - simplywall.st

Jan 09, 2026
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Jan 08, 2026

Aug Breakouts: Is Apellis Pharmaceuticals Inc. stock near bottom after declineMarket Performance Recap & Daily Price Action Insights - ulpravda.ru

Jan 08, 2026
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Jan 08, 2026

Can Apellis Pharmaceuticals Inc. stock sustain institutional interest2025 Investor Takeaways & AI Powered Buy/Sell Recommendations - ulpravda.ru

Jan 08, 2026
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Jan 08, 2026

Can Apellis Pharmaceuticals Inc. (1JK) stock surprise with quarterly resultsJuly 2025 Weekly Recap & Risk Managed Investment Strategies - Улправда

Jan 08, 2026
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Jan 08, 2026

Will Apellis Pharmaceuticals Inc. stock benefit from green energy trendsJuly 2025 Trends & Weekly Watchlist for Consistent Profits - Улправда

Jan 08, 2026
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Jan 08, 2026

How risky is Apellis Pharmaceuticals Inc. (1JK) stock compared to peersBlue Chip Stock Analysis & Superior Wealth Strategies - bollywoodhelpline.com

Jan 08, 2026
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Jan 08, 2026

How buybacks impact Apellis Pharmaceuticals Inc. stock value2025 Buyback Activity & Smart Swing Trading Techniques - Улправда

Jan 08, 2026
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Jan 08, 2026

Why Apellis Pharmaceuticals Inc. stock appeals to dividend seekers - ulpravda.ru

Jan 08, 2026
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Jan 07, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Trading 7.8% HigherWhat's Next? - MarketBeat

Jan 07, 2026
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Jan 07, 2026

Apellis stock jumps nearly 8% as investors look to JPM healthcare update - TechStock²

Jan 07, 2026
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Jan 06, 2026

Apellis Pharmaceuticals, Inc. (APLS) Stock Analysis: Navigating a 40.73% Potential Upside in the Biotech Space - DirectorsTalk Interviews

Jan 06, 2026
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Jan 05, 2026

Apellis Pharmaceuticals to Present at the 44th Annual J.P. Morgan Healthcare Conference - The Manila Times

Jan 05, 2026
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Jan 05, 2026

Oklahoma City NewsThe Oklahoman - FinancialContent

Jan 05, 2026
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Jan 02, 2026

Apellis Pharmaceuticals shows rising relative price performance; still shy of key benchmark - MSN

Jan 02, 2026
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Jan 01, 2026

Resistance Check: Is Apellis Pharmaceuticals Inc stock cheap at current valuation2025 Big Picture & Technical Pattern Based Buy Signals - moha.gov.vn

Jan 01, 2026
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Dec 31, 2025

Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) Receives Average Rating of "Hold" from Analysts - MarketBeat

Dec 31, 2025
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Dec 30, 2025

Simplify Asset Management Inc. Buys New Stake in Apellis Pharmaceuticals, Inc. $APLS - MarketBeat

Dec 30, 2025
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Dec 30, 2025

Institution Moves: How buybacks impact Apellis Pharmaceuticals Inc stock valueJuly 2025 Opening Moves & Weekly Stock Breakout Alerts - moha.gov.vn

Dec 30, 2025
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Dec 30, 2025

Apellis Pharmaceuticals' chief commercial officer sells shares worth $101,103 - MSN

Dec 30, 2025
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Dec 29, 2025

Understanding Momentum Shifts in (APLS) - Stock Traders Daily

Dec 29, 2025
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Dec 27, 2025

Highland Capital Management LLC Takes Position in Apellis Pharmaceuticals, Inc. $APLS - MarketBeat

Dec 27, 2025
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Dec 23, 2025

How sustainable is Apellis Pharmaceuticals Inc. stock dividend payoutInstitutional Buying Trends & Affordable Investment Portfolio - bollywoodhelpline.com

Dec 23, 2025
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Dec 23, 2025

Analysts’ Opinions Are Mixed on These Healthcare Stocks: Apellis Pharmaceuticals (APLS) and Argenx Se (ARGX) - The Globe and Mail

Dec 23, 2025
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Dec 22, 2025

Mizuho Securities Maintains Apellis Pharmaceuticals(APLS.US) With Hold Rating - 富途牛牛

Dec 22, 2025
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Dec 20, 2025

Will Apellis Pharmaceuticals Inc. (1JK) stock outperform foreign stocksEarnings Risk Report & Reliable Volume Spike Trade Alerts - Улправда

Dec 20, 2025
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Dec 20, 2025

Will Apellis Pharmaceuticals Inc. stock see PE expansion2025 Trading Recap & Reliable Price Breakout Signals - Улправда

Dec 20, 2025
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Dec 20, 2025

Stifel maintains Apellis Pharmaceuticals (APLS) buy recommendation - MSN

Dec 20, 2025
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Dec 19, 2025

APLS (Apellis Pharmaceuticals) EV-to-OCF : 39.23 (As of Dec. 19, 2025) - GuruFocus

Dec 19, 2025

Apellis Pharmaceuticals Inc Stock (APLS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$105.95
price up icon 2.44%
$35.34
price up icon 4.34%
$121.22
price up icon 1.06%
$109.12
price up icon 1.80%
$163.46
price down icon 0.16%
biotechnology ONC
$346.75
price down icon 1.23%
Cap:     |  Volume (24h):