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Apellis Pharmaceuticals Inc stock is traded at $20.96, with a volume of 1.87M. It is down -3.14% in the last 24 hours and down -3.90% over the past month. Apellis Pharmaceuticals Inc is a commercial-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system, which is an integral component of the immune system, at the level of C3, the central protein in the complement cascade. Currently it has two marketed drugs that target C3, the central protein in the complement cascade: SYFOVRE (pegcetacoplan injection) and EMPAVELI (pegcetacoplan).
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Previous Close:
$21.64
Open:
$21.3
24h Volume:
1.87M
Relative Volume:
0.68
Market Cap:
$2.68B
Revenue:
$715.22M
Net Income/Loss:
$-250.10M
P/E Ratio:
-10.33
EPS:
-2.03
Net Cash Flow:
$-205.58M
1W Performance:
-5.92%
1M Performance:
-3.90%
6M Performance:
-25.73%
1Y Performance:
-19.38%
1-Day Range:
Value
$20.79
$21.30
1-Week Range:
Value
$20.10
$22.77
52-Week Range:
Value
$16.10
$30.48

Apellis Pharmaceuticals Inc Stock (APLS) Company Profile

Name
Name
Apellis Pharmaceuticals Inc
Name
Phone
617-977-5700
Name
Address
100 FIFTH AVENUE, WALTHAM, KY
Name
Employee
710
Name
Twitter
@ApellisPharma
Name
Next Earnings Date
2024-12-05
Name
Latest SEC Filings
Name
APLS's Discussions on Twitter

Compare APLS vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
APLS
Apellis Pharmaceuticals Inc
20.96 2.77B 715.22M -250.10M -205.58M -2.03
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
496.83 121.97B 12.07B 3.95B 3.19B 15.33
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
781.67 81.49B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
766.92 47.74B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
332.92 43.93B 3.71B 313.75M 465.38M 2.2571
Biotechnology icon
ONC
Beone Medicines Ltd Adr
316.99 35.67B 4.98B 69.60M 525.67M 0.5198

Apellis Pharmaceuticals Inc Stock (APLS) Upgrades & Downgrades

Date Action Analyst Rating Change
Jan-28-26 Initiated Barclays Equal Weight
Jan-21-26 Upgrade BofA Securities Neutral → Buy
Nov-06-25 Initiated Wolfe Research Peer Perform
Oct-15-25 Initiated Wells Fargo Overweight
Sep-26-25 Downgrade Goldman Neutral → Sell
May-09-25 Downgrade BofA Securities Buy → Neutral
May-09-25 Downgrade Raymond James Strong Buy → Outperform
Apr-29-25 Initiated Cantor Fitzgerald Overweight
Dec-17-24 Downgrade Goldman Buy → Neutral
Nov-21-24 Initiated Morgan Stanley Equal-Weight
Oct-25-24 Initiated RBC Capital Mkts Sector Perform
Oct-16-24 Initiated Scotiabank Sector Outperform
Oct-16-24 Initiated William Blair Outperform
May-31-24 Initiated Piper Sandler Neutral
Feb-05-24 Upgrade Jefferies Hold → Buy
Dec-14-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-09-23 Initiated Goldman Buy
Nov-02-23 Initiated Mizuho Neutral
Oct-06-23 Upgrade JP Morgan Neutral → Overweight
Sep-15-23 Upgrade Wells Fargo Equal Weight → Overweight
Aug-29-23 Reiterated Citigroup Buy
Aug-03-23 Downgrade JP Morgan Overweight → Neutral
Aug-01-23 Downgrade BofA Securities Buy → Neutral
Jan-03-23 Downgrade Wells Fargo Overweight → Equal Weight
Nov-10-22 Downgrade Jefferies Buy → Hold
Jul-19-22 Initiated H.C. Wainwright Buy
Jun-17-22 Resumed Stifel Buy
Apr-14-22 Downgrade ROTH Capital Neutral → Sell
Dec-08-21 Initiated Wells Fargo Overweight
Nov-29-21 Downgrade ROTH Capital Buy → Neutral
Sep-10-21 Reiterated BMO Capital Markets Outperform
Sep-10-21 Reiterated Credit Suisse Neutral
Sep-10-21 Reiterated Needham Buy
Sep-10-21 Reiterated Oppenheimer Outperform
Sep-10-21 Downgrade Wedbush Outperform → Neutral
Aug-19-21 Initiated Jefferies Buy
Aug-19-21 Upgrade Wedbush Neutral → Outperform
May-21-21 Initiated UBS Buy
Apr-16-21 Initiated Goldman Buy
Nov-19-20 Initiated Needham Buy
Sep-01-20 Initiated Stifel Buy
Jul-20-20 Initiated ROTH Capital Buy
Jun-17-20 Initiated BTIG Research Neutral
Apr-01-20 Initiated Raymond James Strong Buy
Mar-31-20 Initiated BMO Capital Markets Outperform
Mar-11-20 Upgrade Wedbush Underperform → Neutral
Jan-07-20 Initiated SVB Leerink Mkt Perform
Dec-19-19 Initiated BofA/Merrill Buy
Nov-22-19 Initiated Wedbush Underperform
Nov-05-19 Initiated Credit Suisse Neutral
Aug-01-19 Reiterated Cantor Fitzgerald Overweight
Jul-12-19 Upgrade JP Morgan Neutral → Overweight
Mar-29-19 Initiated Robert W. Baird Outperform
Jan-23-19 Downgrade JP Morgan Overweight → Neutral
Jul-30-18 Upgrade B. Riley FBR Neutral → Buy
May-24-18 Initiated Cantor Fitzgerald Overweight
Apr-12-18 Downgrade B. Riley FBR, Inc. Buy → Neutral
Feb-08-18 Initiated B. Riley FBR, Inc. Buy
View All

Apellis Pharmaceuticals Inc Stock (APLS) Latest News

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Feb 26, 2026

Apellis (APLS) Q4 2025 Earnings Call Transcript - AOL.com

Feb 26, 2026
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Feb 26, 2026

Analysts Issue Forecasts for APLS FY2030 Earnings - MarketBeat

Feb 26, 2026
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Feb 26, 2026

Apellis price target lowered to $18 from $20 at Wedbush - Yahoo Finance

Feb 26, 2026
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Feb 26, 2026

Apellis Pharmaceuticals Experiences Revision in Stock Evaluation Amidst Market Challenges - Markets Mojo

Feb 26, 2026
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Feb 25, 2026

Apogee Therapeutics Stock Up 100% as Fund Lifts Stake to $28 Million - AOL.com

Feb 25, 2026
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Feb 25, 2026

S&E In Brief: Commercial Updates From The SMID Cap Universe - Citeline News & Insights

Feb 25, 2026
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Feb 25, 2026

RBC Capital Adjusts Price Target for Apellis Pharmaceuticals (AP - GuruFocus

Feb 25, 2026
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Feb 25, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Price Target Cut to $44.00 by Analysts at Citigroup - MarketBeat

Feb 25, 2026
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Feb 25, 2026

APLS: Citigroup Maintains Rating, Lowers Price Target to $44.00 - GuruFocus

Feb 25, 2026
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Feb 25, 2026

Mizuho Securities Adjusts Apellis Pharmaceuticals PT to $20 From $19, Maintains Neutral Rating - marketscreener.com

Feb 25, 2026
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Feb 25, 2026

Royal Bank Of Canada Lowers Apellis Pharmaceuticals (NASDAQ:APLS) Price Target to $21.00 - MarketBeat

Feb 25, 2026
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Feb 25, 2026

Apellis Q4 Loss Wider Than Expected, Revenues Decline Y/Y - Nasdaq

Feb 25, 2026
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Feb 25, 2026

Why Apellis Pharmaceuticals Stock Is Under Pressure - TipRanks

Feb 25, 2026
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Feb 25, 2026

RBC Capital Adjusts Apellis Pharmaceuticals PT to $21 From $22, Maintains Sector Perform Rating - marketscreener.com

Feb 25, 2026
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Feb 25, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Price Target Lowered to $18.00 at Wedbush - MarketBeat

Feb 25, 2026
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Feb 25, 2026

APLS: Analyst Wedbush Lowers Price Target to $18 While Maintaini - GuruFocus

Feb 25, 2026
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Feb 25, 2026

H.C. Wainwright raises Apellis stock price target on Syfovre outlook - Investing.com Australia

Feb 25, 2026
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Feb 25, 2026

HC Wainwright & Co. Raises Price Target for APLS to $48.00 | APLS Stock News - GuruFocus

Feb 25, 2026
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Feb 25, 2026

Decoding Apellis Pharmaceuticals Inc (APLS): A Strategic SWOT In - GuruFocus

Feb 25, 2026
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Feb 24, 2026

Apellis Pharmaceuticals, Inc. (APLS) Stock Analysis: Exploring A 51% Upside Potential - DirectorsTalk Interviews

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals (APLS) Profitability Shift Tests Bullish Narratives After Q4 Loss - simplywall.st

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals Q4 2025 Earnings Call Transcript - MarketBeat

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals, Inc. Q4 2025 Earnings Call Summary - Yahoo Finance

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals (NASDAQ:APLS) Shares Gap DownTime to Sell? - MarketBeat

Feb 24, 2026
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Feb 24, 2026

Wedbush Adjusts Apellis Pharmaceuticals Price Target to $18 From $20, Maintains Neutral Rating - marketscreener.com

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals, Inc. (APLS) Surpasses Q4 Earnings and Revenue Estimates - Bitget

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals (APLS) Q4 Earnings: How Key Metrics Compare to Wall Street Estimates - Yahoo Finance

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals Q4 Earnings Call Highlights - Yahoo Finance

Feb 24, 2026
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Feb 24, 2026

Earnings call transcript: Apellis Pharmaceuticals Q4 2025 reveals strong product demand - Investing.com

Feb 24, 2026
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Feb 24, 2026

Apellis (APLS) Surpasses Revenue Expectations in Q4 - GuruFocus

Feb 24, 2026
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Feb 24, 2026

APELLIS PHARMACEUTICALS ($APLS) Releases Q4 2025 Earnings - Quiver Quantitative

Feb 24, 2026
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Feb 24, 2026

Earnings Flash (APLS) Apellis Pharmaceuticals Posts Q4 EPS $0.47, vs. FactSet Est of $0.39 Loss - marketscreener.com

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals Reports Fourth Quarter and Full Year 2025 Financial Results - The Manila Times

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals Earnings Report: Q4 Overview - Benzinga

Feb 24, 2026
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Feb 24, 2026

Apellis Pharmaceuticals, Inc. SEC 10-K Report - TradingView

Feb 24, 2026
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Feb 24, 2026

APELLIS PHARMACEUTICALS INC (NASDAQ:APLS) Pairs Strong Growth with Bullish Chart Setup - ChartMill

Feb 24, 2026
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Feb 23, 2026

A Glimpse of Apellis Pharmaceuticals's Earnings Potential - Benzinga

Feb 23, 2026
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Feb 23, 2026

Apellis earnings on deck: Can new kidney drug revive growth momentum? By Investing.com - Investing.com Canada

Feb 23, 2026
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Feb 23, 2026

Apellis earnings on deck: Can new kidney drug revive growth momentum? - Investing.com Nigeria

Feb 23, 2026
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Feb 23, 2026

Apellis Pharmaceuticals to Present at the TD Cowen 46th Annual Health Care Conference - The Manila Times

Feb 23, 2026
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Feb 23, 2026

(APLS) as a Liquidity Pulse for Institutional Tactics - Stock Traders Daily

Feb 23, 2026
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Feb 21, 2026

Why Apellis Pharmaceuticals, Inc. (APLS) Skyrocketed On Monday - MSN

Feb 21, 2026
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Feb 21, 2026

RTW INVESTMENTS, LP Acquires Significant Stake in Apellis Pharma - GuruFocus

Feb 21, 2026
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Feb 19, 2026

Apellis announces eight oral presentations at the 49th Macula Society annual meeting - marketscreener.com

Feb 19, 2026
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Feb 19, 2026

Apellis Announces Eight Oral Presentations at the 49th Macula Society Annual Meeting - Bitget

Feb 19, 2026
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Feb 19, 2026

5-year SYFOVRE study tackles eye disease that leads to blindness for millions - Stock Titan

Feb 19, 2026
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Feb 19, 2026

Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) Receives Average Recommendation of "Hold" from Analysts - MarketBeat

Feb 19, 2026
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Feb 18, 2026

Readystate Asset Management LP Takes Position in Apellis Pharmaceuticals, Inc. $APLS - MarketBeat

Feb 18, 2026
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Feb 17, 2026

Earnings Preview: Apellis Pharmaceuticals, Inc. (APLS) Q4 Earnings Expected to Decline - Finviz

Feb 17, 2026
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Feb 17, 2026

Apellis Pharmaceuticals (APLS) Expected to Announce Earnings on Tuesday - MarketBeat

Feb 17, 2026
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Feb 15, 2026

BofA upgrades Apellis (APLS) to buy citing rapid Empaveli adoption and underappreciated kidney disease market potential - MSN

Feb 15, 2026

Apellis Pharmaceuticals Inc Stock (APLS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$101.27
price up icon 1.18%
$28.94
price up icon 1.58%
$53.57
price up icon 3.60%
$110.23
price up icon 1.31%
$149.33
price down icon 0.45%
biotechnology ONC
$316.99
price down icon 1.67%
Cap:     |  Volume (24h):