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Alnylam Pharmaceuticals Inc stock is traded at $295.05, with a volume of 926.34K. It is down -0.29% in the last 24 hours and down -9.84% over the past month. Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam's commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam's partners, Novartis and Sanofi, respectively. It also has several clinical programs across various therapeutic areas, including cardio-metabolic diseases, neuroscience, and hematology.
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Previous Close:
$295.91
Open:
$295.91
24h Volume:
926.34K
Relative Volume:
0.76
Market Cap:
$39.39B
Revenue:
$4.29B
Net Income/Loss:
$577.22M
P/E Ratio:
70.11
EPS:
4.2086
Net Cash Flow:
$641.34M
1W Performance:
-0.36%
1M Performance:
-9.84%
6M Performance:
-33.35%
1Y Performance:
+14.21%
1-Day Range:
Value
$293.06
$300.17
1-Week Range:
Value
$288.06
$306.03
52-Week Range:
Value
$250.35
$495.55

Alnylam Pharmaceuticals Inc Stock (ALNY) Company Profile

Name
Name
Alnylam Pharmaceuticals Inc
Name
Phone
(617) 551-8200
Name
Address
675 WEST KENDALL STREET, CAMBRIDGE, MA
Name
Employee
2,500
Name
Twitter
@alnylam
Name
Next Earnings Date
2026-04-30
Name
Latest SEC Filings
Name
ALNY's Discussions on Twitter

Compare ALNY vs VRTX, REGN, ARGX, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
295.05 39.39B 4.29B 577.22M 641.34M 4.2086
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
429.82 109.09B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
714.89 74.95B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
782.17 48.64B 4.16B 1.29B 734.26M 19.58
ONC icon
ONC
Beone Medicines Ltd Adr
312.12 32.38B 5.36B 287.73M 924.18M 2.5229

Alnylam Pharmaceuticals Inc Stock (ALNY) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-16-26 Downgrade Jefferies Buy → Hold
Jan-28-26 Resumed Barclays Overweight
Jan-07-26 Resumed Oppenheimer Outperform
Aug-04-25 Upgrade Oppenheimer Perform → Outperform
Aug-04-25 Upgrade Wolfe Research Underperform → Peer Perform
Jul-30-25 Resumed Raymond James Outperform
Jul-21-25 Initiated Truist Buy
Mar-31-25 Initiated Redburn Atlantic Buy
Mar-24-25 Upgrade JP Morgan Neutral → Overweight
Nov-12-24 Downgrade Wolfe Research Peer Perform → Underperform
Oct-16-24 Initiated Scotiabank Sector Outperform
Aug-16-24 Upgrade Goldman Neutral → Buy
Feb-16-24 Downgrade Goldman Buy → Neutral
Feb-15-24 Initiated Wolfe Research Peer Perform
Dec-08-23 Initiated Wells Fargo Equal Weight
Oct-11-23 Downgrade Oppenheimer Outperform → Perform
Sep-29-23 Initiated Raymond James Outperform
May-05-23 Upgrade BMO Capital Markets Market Perform → Outperform
Apr-26-23 Initiated SMBC Nikko Neutral
Mar-21-23 Initiated Bernstein Outperform
Jan-18-23 Initiated Canaccord Genuity Buy
Sep-09-22 Resumed Morgan Stanley Equal-Weight
Jul-13-22 Initiated Cantor Fitzgerald Neutral
Jun-27-22 Downgrade Guggenheim Buy → Neutral
Jun-07-22 Initiated William Blair Outperform
Apr-25-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Mar-01-22 Initiated Citigroup Buy
Feb-03-22 Upgrade Guggenheim Neutral → Buy
Jan-03-22 Upgrade Piper Sandler Neutral → Overweight
Nov-22-21 Upgrade Goldman Neutral → Buy
Nov-22-21 Upgrade RBC Capital Mkts Sector Perform → Outperform
Nov-01-21 Upgrade Oppenheimer Perform → Outperform
Oct-04-21 Upgrade UBS Neutral → Buy
Aug-04-21 Downgrade Piper Sandler Overweight → Neutral
Feb-22-21 Downgrade Guggenheim Buy → Neutral
Feb-12-21 Downgrade Citigroup Buy → Neutral
Feb-12-21 Reiterated H.C. Wainwright Buy
Jan-25-21 Downgrade BMO Capital Markets Outperform → Market Perform
Sep-30-20 Resumed Berenberg Hold
Sep-08-20 Initiated Citigroup Buy
Aug-11-20 Downgrade Oppenheimer Outperform → Perform
May-13-20 Initiated RBC Capital Mkts Sector Perform
May-07-20 Downgrade JP Morgan Overweight → Neutral
Apr-24-20 Resumed Evercore ISI Outperform
Mar-19-20 Initiated Berenberg Buy
Dec-19-19 Reiterated Chardan Capital Markets Buy
Nov-20-19 Initiated Oppenheimer Outperform
Nov-13-19 Initiated BofA/Merrill Buy
May-23-19 Resumed Goldman Neutral
Apr-12-19 Initiated Evercore ISI Outperform
Mar-06-19 Upgrade Evercore ISI In-line → Outperform
Mar-05-19 Upgrade Morgan Stanley Equal-Weight → Overweight
Jan-23-19 Initiated UBS Neutral
Oct-01-18 Initiated Cantor Fitzgerald Overweight
Aug-13-18 Reiterated Stifel Buy
Aug-07-18 Upgrade Stifel Hold → Buy
May-04-18 Reiterated Stifel Hold
Mar-28-18 Initiated Evercore ISI In-line
View All

Alnylam Pharmaceuticals Inc Stock (ALNY) Latest News

pulisher
May 08, 2026

A Look At Alnylam Pharmaceuticals (ALNY) Valuation After Recent Share Price Weakness - Yahoo Finance

May 08, 2026
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May 08, 2026

Is It Time To Reconsider Alnylam Pharmaceuticals (ALNY) After Recent RNAi Progress And Volatile Price Moves - simplywall.st

May 08, 2026
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May 07, 2026

Heart drug vutrisiran shows steady profile in new analyses - Longevity.Technology

May 07, 2026
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May 07, 2026

FDA’s Untitled Letter tells Alnylam its Amvuttra survival claims don’t quite add up - Medical Marketing and Media

May 07, 2026
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May 07, 2026

Porphyria Treatment Market to Reach USD 2.56 Billion by 2033 - openPR.com

May 07, 2026
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May 07, 2026

Alnylam to Webcast Presentations at Upcoming Investor Conferences - Yahoo Finance

May 07, 2026
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May 06, 2026

Tenaya (NASDAQ: TNYA) trims R&D burn and signs Alnylam research pact - Stock Titan

May 06, 2026
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May 06, 2026

Tenaya Therapeutics (NASDAQ: TNYA) trims Q1 loss, lands Alnylam deal - Stock Titan

May 06, 2026
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May 06, 2026

Alnylam Pharmaceuticals | SCHEDULE 13G/A: Others - Moomoo

May 06, 2026
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May 06, 2026

FMR LLC amends Schedule 13G to show 14.64M ALNY shares (NASDAQ: ALNY) - Stock Titan

May 06, 2026
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May 06, 2026

Barclays Maintains Alnylam Pharmaceuticals(ALNY.US) With Buy Rating, Maintains Target Price $527 - Moomoo

May 06, 2026
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May 06, 2026

ALNY Stock Price, Quote & Chart | ALNYLAM PHARMACEUTICALS INC (NASDAQ:ALNY) - ChartMill

May 06, 2026
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May 05, 2026

H.C. Wainwright reiterates Alnylam stock rating on strong TTR sales By Investing.com - Investing.com Canada

May 05, 2026
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May 05, 2026

Competitive Landscape: Leading Companies and Emerging Competitors in the Vutrisiran Market - openPR.com

May 05, 2026
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May 05, 2026

H.C. Wainwright Maintains Alnylam Pharmaceuticals(ALNY.US) With Buy Rating, Maintains Target Price $510 - Moomoo

May 05, 2026
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May 05, 2026

Alnylam Pharmaceuticals (ALNY) Valuation After Q1 2026 Profit Breakthrough And Revenue Surge - simplywall.st

May 05, 2026
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May 04, 2026

MSN Money - MSN

May 04, 2026
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May 04, 2026

CCORF Maintains Alnylam Pharmaceuticals(ALNY.US) With Buy Rating, Maintains Target Price $429 - Moomoo

May 04, 2026
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May 04, 2026

Alnylam to Present New Analyses at Heart Failure 2026 Underscoring Consistent Clinical Profile of Vutrisiran in ATTR-CM - Business Wire

May 04, 2026
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May 04, 2026

Alnylam Pharmaceuticals, Inc. (ALNY) Stock Analysis: Navigating a 51.79% Potential Upside in the Biotech Sector - DirectorsTalk Interviews

May 04, 2026
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May 04, 2026

Alnylam Pharmaceuticals Q1 2026 earnings preview - MSN

May 04, 2026
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May 03, 2026

Should Alnylam’s Billion‑Dollar Quarter and Return to Profitability Require Action From Alnylam Pharmaceuticals (ALNY) Investors? - simplywall.st

May 03, 2026
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May 03, 2026

Alnylam Pharmaceuticals, Inc. Beat Analyst Estimates: See What The Consensus Is Forecasting For This Year - Yahoo Finance

May 03, 2026
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May 03, 2026

Hussman Strategic Advisors Inc. Buys Shares of 6,300 Alnylam Pharmaceuticals, Inc. $ALNY - MarketBeat

May 03, 2026
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May 03, 2026

Alnylam Pharmaceuticals, Inc. $ALNY Shares Sold by Kornitzer Capital Management Inc. KS - MarketBeat

May 03, 2026
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May 03, 2026

Alnylam Pharmaceuticals, Inc. $ALNY Shares Bought by Danske Bank A S - MarketBeat

May 03, 2026
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May 03, 2026

Alnylam Pharmaceuticals (ALNY) Financials 2026Income Statement and Balance Sheet - MarketBeat

May 03, 2026
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May 02, 2026

A Quick Look at Today's Ratings for Alnylam Pharmaceuticals(ALNY.US), With a Forecast Between $370 to $500 - Moomoo

May 02, 2026
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May 02, 2026

Raymond James Reaffirms Their Hold Rating on Alnylam Pharma (ALNY) - The Globe and Mail

May 02, 2026
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May 02, 2026

Alnylam Pharma (ALNY) Gets a Buy from Bernstein - The Globe and Mail

May 02, 2026
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May 02, 2026

Alnylam Pharmaceuticals (NASDAQ:ALNY) Upgraded at Wall Street Zen - MarketBeat

May 02, 2026
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May 01, 2026

Alnylam slips 4.3% as investors digest Q1 results and unchanged full-year outlook - Quiver Quantitative

May 01, 2026
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May 01, 2026

ALNY Maintained by RBC Capital -- Price Target Lowered to $445 - GuruFocus

May 01, 2026
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May 01, 2026

ALNY Maintained by Wells Fargo -- Price Target Raised to $377 - GuruFocus

May 01, 2026
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May 01, 2026

Royal Bank Of Canada Has Lowered Expectations for Alnylam Pharmaceuticals (NASDAQ:ALNY) Stock Price - MarketBeat

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals: The RNAi Leader Continues To Grind Through A Quieter Year - Seeking Alpha

May 01, 2026
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May 01, 2026

Alnylam Q1 Earnings Beat Estimates, Amvuttra Sales Drive Y/Y Growth - Yahoo Finance

May 01, 2026
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May 01, 2026

Bernstein SocGen lowers Alnylam stock price target on valuation By Investing.com - Investing.com Canada

May 01, 2026
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May 01, 2026

Bernstein SocGen lowers Alnylam stock price target on valuation - Investing.com

May 01, 2026
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May 01, 2026

Wells Fargo & Company Issues Positive Forecast for Alnylam Pharmaceuticals (NASDAQ:ALNY) Stock Price - MarketBeat

May 01, 2026
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May 01, 2026

RBC Capital Maintains Alnylam Pharmaceuticals(ALNY.US) With Buy Rating, Cuts Target Price to $445 - Moomoo

May 01, 2026
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May 01, 2026

RBC Trims Price Target on Alnylam Pharmaceuticals to $445 From $450, Keeps Outperform Rating - marketscreener.com

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals Backs 2026 Views >ALNY - Moomoo

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals, Inc. $ALNY Shares Sold by Jennison Associates LLC - MarketBeat

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals Inc (ALNY) Q1 2026 Earnings Call Highlig - GuruFocus

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals (ALNY) Earnings Turn To Profitability Challenges Premium P/E Narrative - simplywall.st

May 01, 2026
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May 01, 2026

Congress Large Cap Growth Fund's Alnylam Pharmaceuticals Inc(ALNY) Holding History - GuruFocus

May 01, 2026
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May 01, 2026

Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Q1 2026 Earnings Call Transcript - Insider Monkey

May 01, 2026
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May 01, 2026

ALNY SWOT Analysis: Strong Growth Potential Revealed in 10-Q Fil - GuruFocus

May 01, 2026
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Apr 30, 2026

Alnylam Pharmaceuticals, Inc. 2026 Q1ResultsEarnings Call Presentation (NASDAQ:ALNY) 2026-04-30 - Seeking Alpha

Apr 30, 2026
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Apr 30, 2026

TD Cowen Maintains Alnylam Pharmaceuticals(ALNY.US) With Buy Rating, Maintains Target Price $482 - Moomoo

Apr 30, 2026

Alnylam Pharmaceuticals Inc Stock (ALNY) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Alnylam Pharmaceuticals Inc Stock (ALNY) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
McLaughlin Melissa
Chief Human Resources Officer
Apr 02 '26
Sale
319.59
1,624
519,014
11,729
ONC ONC
$312.12
price down icon 1.54%
$141.81
price down icon 0.49%
$782.17
price down icon 0.65%
$94.12
price up icon 1.19%
$50.79
price up icon 1.18%
Cap:     |  Volume (24h):