20.37
price up icon1.75%   0.35
pre-market  Pre-market:  20.12   -0.25   -1.23%
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Denali Therapeutics Inc stock is traded at $20.37, with a volume of 1.23M. It is up +1.75% in the last 24 hours and down -4.28% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$20.02
Open:
$20.29
24h Volume:
1.23M
Relative Volume:
0.75
Market Cap:
$3.18B
Revenue:
$340.81M
Net Income/Loss:
$-419.65M
P/E Ratio:
-7.1474
EPS:
-2.85
Net Cash Flow:
$-402.10M
1W Performance:
-8.61%
1M Performance:
-4.28%
6M Performance:
+37.73%
1Y Performance:
+27.71%
1-Day Range:
Value
$19.94
$20.92
1-Week Range:
Value
$19.76
$22.39
52-Week Range:
Value
$10.57
$23.77

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
517
Name
Twitter
Name
Next Earnings Date
2025-08-08
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
DNLI
Denali Therapeutics Inc
20.37 3.13B 340.81M -419.65M -402.10M -2.85
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
477.89 120.48B 12.07B 3.95B 3.19B 15.33
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
787.50 81.05B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
749.56 46.33B 4.16B 1.29B 734.26M 19.59
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
327.30 42.26B 3.71B 313.75M 465.38M 2.2571
Biotechnology icon
ONC
Beone Medicines Ltd Adr
299.02 32.87B 5.36B 287.73M 924.18M 2.5229

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
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Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
Mar 04, 2026

DNLI: Pivotal 2026 ahead with FDA review, new launches, and major clinical milestones in rare diseases - TradingView

Mar 04, 2026
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Mar 04, 2026

Fisher Asset Management LLC Increases Holdings in Denali Therapeutics Inc. $DNLI - MarketBeat

Mar 04, 2026
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Mar 03, 2026

Assessing Denali Therapeutics (DNLI) Valuation After Wider Losses And New Shelf Registration - Sahm

Mar 03, 2026
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Mar 03, 2026

Denali Therapeutics Inc. (DNLI) Investor Outlook: Analyzing The 56.80% Potential Upside - DirectorsTalk Interviews

Mar 03, 2026
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Mar 03, 2026

Vanguard Group Inc. Purchases 182,183 Shares of Denali Therapeutics Inc. $DNLI - MarketBeat

Mar 03, 2026
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Mar 02, 2026

Jefferies reiterates Denali stock Buy rating on gene therapy outlook By Investing.com - Investing.com India

Mar 02, 2026
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Mar 02, 2026

Jefferies reiterates Denali stock Buy rating on gene therapy outlook - Investing.com

Mar 02, 2026
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Mar 02, 2026

BTIG Research Increases Denali Therapeutics (NASDAQ:DNLI) Price Target to $36.00 - MarketBeat

Mar 02, 2026
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Mar 01, 2026

Denali Therapeutics Inc. Trade Ideas — GETTEX:4DN - TradingView

Mar 01, 2026
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Feb 27, 2026

DNLI Q4 Loss Narrower Than Expected, Hunter Syndrome Drug in Focus - Finviz

Feb 27, 2026
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Feb 27, 2026

Denali Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Business Highlights - National Today

Feb 27, 2026
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Feb 27, 2026

DNLI Should I Buy - Intellectia AI

Feb 27, 2026
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Feb 26, 2026

Does Denali Therapeutics' (DNLI) Widening Quarterly Loss Reframe Its Pipeline-First Investment Narrative? - simplywall.st

Feb 26, 2026
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Feb 26, 2026

Denali Therapeutics (NASDAQ:DNLI) Announces Quarterly Earnings Results, Beats Estimates By $0.02 EPS - MarketBeat

Feb 26, 2026
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Feb 26, 2026

Denali Therapeutics Q4 net loss deepens - TradingView

Feb 26, 2026
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Feb 26, 2026

Denali Therapeutics (DNLI) widens 2025 loss but fortifies cash for key 2026 drug milestones - Stock Titan

Feb 26, 2026
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Feb 26, 2026

Hunter syndrome drug nears April FDA call as Denali raises $475M - Stock Titan

Feb 26, 2026
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Feb 25, 2026

Volume Recap: Is Denali Therapeutics Inc. a turnaround storyMarket Weekly Review & Weekly Chart Analysis and Guides - baoquankhu1.vn

Feb 25, 2026
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Feb 24, 2026

Denali Therapeutics Inc. (DNLI) Stock Analysis: Strong Buy Ratings Signal a 57% Potential Upside - DirectorsTalk Interviews

Feb 24, 2026
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Feb 24, 2026

Wolfe Research initiates Denali Therapeutics stock with Peerperform - Investing.com

Feb 24, 2026
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Feb 24, 2026

Wolfe Research initiates Denali Therapeutics stock with Peerperform By Investing.com - Investing.com UK

Feb 24, 2026
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Feb 24, 2026

Wolfe Research Initiates Coverage of Denali Therapeutics (DNLI) with Peer Perform Recommendation - Nasdaq

Feb 24, 2026
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Feb 24, 2026

(DNLI) as a Liquidity Pulse for Institutional Tactics - Stock Traders Daily

Feb 24, 2026
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Feb 19, 2026

Buyout Rumor: Is Denali Therapeutics Inc forming a bullish divergenceJuly 2025 Action & Accurate Intraday Trade Tips - baoquankhu1.vn

Feb 19, 2026
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Feb 19, 2026

Aug Action: Will ORKA stock recover after earningsInsider Selling & Weekly Setup with ROI Potential - baoquankhu1.vn

Feb 19, 2026
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Feb 19, 2026

Aberdeen Group plc Buys 210,835 Shares of Denali Therapeutics Inc. $DNLI - Defense World

Feb 19, 2026
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Feb 19, 2026

Denali Therapeutics (DNLI) Expected to Announce Earnings on Thursday - MarketBeat

Feb 19, 2026
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Feb 18, 2026

Denali Therapeutics Inc. $DNLI Shares Sold by Thrivent Financial for Lutherans - Defense World

Feb 18, 2026
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Feb 18, 2026

Pharma could be on the cusp of finally breaking the blood-brain barrier - Pharma Voice

Feb 18, 2026
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Feb 15, 2026

Big Picture: Why is Denali Therapeutics Inc stock going downJuly 2025 Momentum & Stepwise Trade Signal Guides - baoquankhu1.vn

Feb 15, 2026
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Feb 14, 2026

How Denali Therapeutics Inc. stock performs in rate cut cyclesJuly 2025 Analyst Calls & Long Hold Capital Preservation Plans - mfd.ru

Feb 14, 2026
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Feb 14, 2026

Denali Therapeutics Inc. (NASDAQ:DNLI) Receives Consensus Recommendation of "Buy" from Analysts - MarketBeat

Feb 14, 2026
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Feb 13, 2026

(DNLI) Risk Channels and Responsive Allocation - Stock Traders Daily

Feb 13, 2026
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Feb 09, 2026

Ideas Watch: Is Denali Therapeutics Inc. a turnaround storyEarnings Growth Summary & Smart Money Movement Tracker - baoquankhu1.vn

Feb 09, 2026
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Feb 09, 2026

Assessing Denali Therapeutics (DNLI) Valuation After WORLDSymposium Clinical Updates And Regulatory Progress - Sahm

Feb 09, 2026
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Feb 09, 2026

Principal Financial Group Inc. Purchases 198,207 Shares of Denali Therapeutics Inc. $DNLI - MarketBeat

Feb 09, 2026
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Feb 07, 2026

Denali Therapeutics (DNLI) Gets a Buy from Wedbush - The Globe and Mail

Feb 07, 2026
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Feb 07, 2026

Analysts Offer Insights on Healthcare Companies: IQVIA Holdings (IQV), Haemonetics (HAE) and Denali Therapeutics (DNLI) - The Globe and Mail

Feb 07, 2026
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Feb 07, 2026

Published on: 2026-02-08 06:47:50 - baoquankhu1.vn

Feb 07, 2026
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Feb 06, 2026

Denali Therapeutics (NASDAQ:DNLI) Earns Buy Rating from BTIG Research - MarketBeat

Feb 06, 2026
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Feb 06, 2026

Earnings Recap: Is Denali Therapeutics Inc forming a bullish divergenceBull Run & Advanced Swing Trade Entry Plans - baoquankhu1.vn

Feb 06, 2026
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Feb 06, 2026

Denali Therapeutics Presents Enzyme TransportVehicle™ Progress Across Three Clinical Programs for Treatment of Lysosomal Storage Disorders at 2026 WORLDSymposium™ - The Manila Times

Feb 06, 2026
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Feb 05, 2026

Denali Therapeutics Showcases ETV Data at WORLD: TIVI PDUFA Near, DNL126 Hits 80% CSF Drop - MarketBeat

Feb 05, 2026
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Feb 05, 2026

DNLI: Sustained biomarker normalization and clinical gains achieved in Hunter syndrome and MPS IIIA - TradingView

Feb 05, 2026
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Feb 05, 2026

Denali Therapeutics Reports Promising Clinical Trial Data for Tividenofusp Alfa and Other Enzyme Replacement Therapies in Lysosomal Storage Disorders - Quiver Quantitative

Feb 05, 2026
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Feb 05, 2026

Trial data track Denali enzyme drugs for rare brain and muscle diseases - Stock Titan

Feb 05, 2026
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Feb 04, 2026

A Look At Denali Therapeutics (DNLI) Valuation As New ETV Rare Disease Data Presentations Approach - Yahoo Finance

Feb 04, 2026
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Feb 04, 2026

How Denali’s Brain-Targeted ETV Data and FDA Review Will Impact Denali Therapeutics (DNLI) Investors - Yahoo Finance

Feb 04, 2026
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Feb 03, 2026

Denali Therapeutics Inc. (DNLI): Investor Outlook Reveals 44.49% Potential Upside In Neurodegenerative Drug Development - DirectorsTalk Interviews

Feb 03, 2026
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Feb 03, 2026

5 Drug/Biotech Stocks Likely to Outperform Q4 Earnings Estimates - TradingView

Feb 03, 2026
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Feb 03, 2026

Is Denali Therapeutics Inc stock suitable for long term investingJuly 2025 Sentiment & Weekly High Conviction Ideas - baoquankhu1.vn

Feb 03, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$47.43
price down icon 0.11%
$29.52
price up icon 6.00%
$57.80
price up icon 15.99%
$103.80
price up icon 3.02%
$149.88
price up icon 1.96%
biotechnology ONC
$299.02
price up icon 0.67%
Cap:     |  Volume (24h):