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Denali Therapeutics Inc stock is traded at $22.30, with a volume of 100.27K. It is up +7.03% in the last 24 hours and up +4.79% over the past month. Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
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Previous Close:
$20.97
Open:
$22.53
24h Volume:
100.27K
Relative Volume:
0.06
Market Cap:
$3.55B
Revenue:
$1.27M
Net Income/Loss:
$-512.54M
P/E Ratio:
-7.509
EPS:
-2.9691
Net Cash Flow:
$-422.10M
1W Performance:
+13.65%
1M Performance:
+4.79%
6M Performance:
+60.90%
1Y Performance:
+62.53%
1-Day Range:
Value
$22.22
$22.58
1-Week Range:
Value
$19.63
$23.46
52-Week Range:
Value
$10.57
$23.77

Denali Therapeutics Inc Stock (DNLI) Company Profile

Name
Name
Denali Therapeutics Inc
Name
Phone
(650) 866-8547
Name
Address
161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO
Name
Employee
503
Name
Twitter
Name
Next Earnings Date
2025-08-08
Name
Latest SEC Filings
Name
DNLI's Discussions on Twitter

Compare DNLI vs VRTX, REGN, ALNY, ARGX, INSM

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
DNLI icon
DNLI
Denali Therapeutics Inc
22.39 3.56B 1.27M -512.54M -422.10M -2.9691
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
452.54 115.58B 12.07B 3.95B 3.19B 15.33
REGN icon
REGN
Regeneron Pharmaceuticals Inc
752.21 79.23B 14.34B 4.50B 3.77B 41.56
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
329.05 43.59B 3.71B 313.75M 465.38M 2.2571
ARGX icon
ARGX
Argen X Se Adr
691.35 43.26B 4.16B 1.29B 734.26M 19.58
INSM icon
INSM
Insmed Inc
146.63 31.97B 606.42M -1.28B -997.58M -6.403

Denali Therapeutics Inc Stock (DNLI) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-24-26 Initiated Wolfe Research Peer Perform
Jan-07-26 Resumed UBS Buy
Apr-10-25 Upgrade Cantor Fitzgerald Neutral → Overweight
Mar-07-25 Resumed Morgan Stanley Overweight
Feb-11-25 Initiated Deutsche Bank Buy
Jan-07-25 Initiated Robert W. Baird Outperform
Jan-03-25 Initiated William Blair Outperform
Dec-16-24 Upgrade Stifel Hold → Buy
Oct-10-24 Resumed Raymond James Mkt Perform
Oct-07-24 Downgrade Cantor Fitzgerald Overweight → Neutral
Dec-13-23 Initiated Citigroup Buy
Nov-20-23 Resumed JP Morgan Overweight
Oct-24-23 Resumed Cantor Fitzgerald Overweight
Sep-06-23 Initiated B. Riley Securities Buy
Jan-30-23 Initiated SVB Securities Outperform
Dec-05-22 Initiated Cowen Outperform
Nov-02-22 Upgrade BTIG Research Neutral → Buy
Nov-02-22 Initiated BofA Securities Buy
Jun-23-22 Initiated Berenberg Buy
Dec-10-21 Resumed Raymond James Mkt Perform
Sep-21-21 Initiated Oppenheimer Outperform
Sep-01-21 Initiated SMBC Nikko Outperform
May-18-21 Initiated UBS Buy
Feb-26-21 Reiterated H.C. Wainwright Buy
Feb-10-21 Upgrade Cantor Fitzgerald Neutral → Overweight
Nov-11-20 Reiterated H.C. Wainwright Buy
Oct-16-20 Downgrade BTIG Research Buy → Neutral
Sep-14-20 Resumed JP Morgan Overweight
Aug-20-20 Reiterated H.C. Wainwright Buy
Mar-13-20 Upgrade Evercore ISI In-line → Outperform
Feb-28-20 Upgrade Wedbush Neutral → Outperform
Feb-24-20 Initiated Jefferies Buy
Feb-19-20 Initiated Stifel Hold
Jan-27-20 Upgrade Goldman Neutral → Buy
Sep-26-19 Initiated Wedbush Neutral
Sep-13-19 Initiated Nomura Buy
Aug-09-19 Initiated BTIG Research Buy
Jun-26-19 Initiated H.C. Wainwright Buy
Nov-15-18 Initiated Cantor Fitzgerald Overweight
Nov-12-18 Initiated Janney Buy
Mar-12-18 Downgrade Evercore ISI Outperform → In-line
Jan-02-18 Initiated Evercore ISI Outperform
Jan-02-18 Initiated Goldman Neutral
Jan-02-18 Initiated JP Morgan Overweight
Jan-02-18 Initiated Morgan Stanley Overweight
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Denali Therapeutics Inc Stock (DNLI) Latest News

pulisher
08:03 AM

Some 13 years and $2 billion later, Denali Therapeutics wins first drug approval - The Business Journals

08:03 AM
pulisher
04:40 AM

FDA approves drug to treat neurologic manifestations of Hunter syndrome - The Pharma Letter

04:40 AM
pulisher
Mar 25, 2026

Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II) - BioSpace

Mar 25, 2026
pulisher
Mar 25, 2026

Denali approval revives surrogate-endpoint path in neuronal MPS - BioCentury

Mar 25, 2026
pulisher
Mar 25, 2026

Stifel raises Denali Therapeutics price target on drug approval - Investing.com

Mar 25, 2026
pulisher
Mar 25, 2026

Goldman Sachs raises Denali Therapeutics stock price target on FDA approval - Investing.com

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics Wins FDA Accelerated Approval for AVLAYAH in Hunter Syndrome, Eyes Launch Boost - Yahoo Finance

Mar 25, 2026
pulisher
Mar 25, 2026

Early FDA wins: Corcept’s Lifyorli, Denali’s Avlayah - BioWorld MedTech

Mar 25, 2026
pulisher
Mar 25, 2026

BTIG raises Denali Therapeutics price target to $38 on drug approval - Investing.com Canada

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics Gains FDA Approval for AVLAYAH Therapy - TipRanks

Mar 25, 2026
pulisher
Mar 25, 2026

FDA clears Denali (NASDAQ: DNLI) AVLAYAH therapy for Hunter syndrome - Stock Titan

Mar 25, 2026
pulisher
Mar 25, 2026

FDA approves Denali’s Hunter syndrome brain therapy AVLAYAH By Investing.com - Investing.com India

Mar 25, 2026
pulisher
Mar 25, 2026

FDA approves Denali Therapeutics drug for Hunter syndrome - statnews.com

Mar 25, 2026
pulisher
Mar 25, 2026

Oppenheimer raises Denali Therapeutics price target on FDA approval - Investing.com

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics Inc. announced that its new drug Avlayah will soon be available on the US market after receiving regulatory approval. - Bitget

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics announces U.S. FDA approval of Avlayah(TM) (tividenofusp alfa-eknm) for treatment of Hunter syndrome (MPS II) - marketscreener.com

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics Announces U.S. FDA Approval Of Avlayah™ (Tividenofusp Alfa-Eknm) For Treatment Of Hunter Syndrome (Mps Ii) - TradingView

Mar 25, 2026
pulisher
Mar 25, 2026

Denali Therapeutics (NASDAQ:DNLI) Shares Gap UpStill a Buy? - MarketBeat

Mar 25, 2026
pulisher
Mar 25, 2026

US FDA approves Denali's genetic disorder therapy for children - Reuters

Mar 25, 2026
pulisher
Mar 25, 2026

Gap Down: Is Denali Therapeutics Inc on track to beat earningsEarnings Trend Report & Accurate Technical Buy Alerts - baoquankhu1.vn

Mar 25, 2026
pulisher
Mar 25, 2026

Denali stock gains on FDA nod for lead asset (DNLI:NASDAQ) - Seeking Alpha

Mar 25, 2026
pulisher
Mar 21, 2026

Bearish Setup: Why is Denali Therapeutics Inc stock going downQuarterly Profit Report & Daily Technical Forecast Reports - baoquankhu1.vn

Mar 21, 2026
pulisher
Mar 21, 2026

Published on: 2026-03-22 06:29:27 - baoquankhu1.vn

Mar 21, 2026
pulisher
Mar 20, 2026

Aug Shorts: Can Denali Therapeutics Inc withstand a market correction2026 Retail & Step-by-Step Trade Execution Guides - baoquankhu1.vn

Mar 20, 2026
pulisher
Mar 20, 2026

Amyotrophic Lateral Sclerosis Market: Strong Pharma Growth Forecast Through 2034 – DelveInsight | Helixmith, Sanofi, Denali Therapeutics, Transposon Therapeutics, GSK, Biogen, Ionis Pharmaceuticals - Barchart.com

Mar 20, 2026
pulisher
Mar 19, 2026

EV Market: How sensitive is Denali Therapeutics Inc to inflationProfit Target & Expert Approved Momentum Trade Ideas - baoquankhu1.vn

Mar 19, 2026
pulisher
Mar 19, 2026

Denali Therapeutics CEO: 2026 Pivotal With Hunter Syndrome FDA Decision and New TV Trial Readouts - MarketBeat

Mar 19, 2026
pulisher
Mar 18, 2026

Transcript : Denali Therapeutics Inc. Presents at Leerink Global Healthcare Conference 2026, Mar-09-2026 03 - marketscreener.com

Mar 18, 2026
pulisher
Mar 18, 2026

Price-Driven Insight from (DNLI) for Rule-Based Strategy - Stock Traders Daily

Mar 18, 2026
pulisher
Mar 17, 2026

Pharma News: Is Denali Therapeutics Inc stock suitable for long term investing2026 Levels & Weekly Stock Breakout Alerts - baoquankhu1.vn

Mar 17, 2026
pulisher
Mar 17, 2026

Holocene Advisors LP Grows Stake in Denali Therapeutics Inc. $DNLI - MarketBeat

Mar 17, 2026
pulisher
Mar 16, 2026

1,000,000 Shares in Denali Therapeutics Inc. $DNLI Purchased by Foresite Capital Management VI LLC - MarketBeat

Mar 16, 2026
pulisher
Mar 16, 2026

Denali’s Hunter Syndrome Candidate in the Spotlight After REGENXBIO Rejection - BioSpace

Mar 16, 2026
pulisher
Mar 15, 2026

Denali Therapeutics Teases April 5 FDA Decision for Tivi as Launch Plans and Pipeline Catalysts Build - MarketBeat

Mar 15, 2026
pulisher
Mar 15, 2026

250,000 Shares in Denali Therapeutics Inc. $DNLI Bought by Boxer Capital Management LLC - MarketBeat

Mar 15, 2026
pulisher
Mar 14, 2026

Analysts Offer Insights on Healthcare Companies: Denali Therapeutics (DNLI) and Oruka Therapeutics (ORKA) - The Globe and Mail

Mar 14, 2026
pulisher
Mar 13, 2026

Denali Therapeutics (DNLI) Is Up 5.1% After Highlighting Tividenofusp Alfa Ahead Of FDA Decision – Has The Bull Case Changed? - Yahoo Finance

Mar 13, 2026
pulisher
Mar 13, 2026

DNLI News & Events - Intellectia AI

Mar 13, 2026
pulisher
Mar 13, 2026

Assessing Denali Therapeutics (DNLI) Valuation After A Strong Year Of Share Price Gains - Yahoo Finance

Mar 13, 2026
pulisher
Mar 11, 2026

Denali Rises 11.8% Over the Past Month: Should You Buy, Sell, or Keep the Stock? - Bitget

Mar 11, 2026
pulisher
Mar 11, 2026

Denali Gains 11.8% in a Month: Buy, Sell or Hold the Stock? - TradingView

Mar 11, 2026
pulisher
Mar 11, 2026

Denali Therapeutics Inc. (NASDAQ:DNLI) Given Consensus Recommendation of "Moderate Buy" by Analysts - MarketBeat

Mar 11, 2026
pulisher
Mar 10, 2026

A Look At Denali Therapeutics (DNLI) Valuation After Wider Losses And New US$200 Million Shelf Registration - Sahm

Mar 10, 2026
pulisher
Mar 10, 2026

Denali ‘Moving In A Positive Direction’ With FDA Toward Hunter Drug Action Date - Citeline News & Insights

Mar 10, 2026
pulisher
Mar 09, 2026

DNLI: Awaiting FDA decision on a novel Hunter syndrome therapy, with broad pipeline and commercial momentum - TradingView

Mar 09, 2026
pulisher
Mar 09, 2026

DNLI: Imminent FDA decision and expanding pipeline highlight strong clinical and commercial momentum - TradingView

Mar 09, 2026
pulisher
Mar 09, 2026

Denali Therapeutics (NASDAQ:DNLI) Trading Up 6.1%Should You Buy? - MarketBeat

Mar 09, 2026
pulisher
Mar 09, 2026

Relmada Therapeutics, Xenon Pharmaceuticals, Dianthus Therapeutics And Other Big Stocks Moving Higher On Monday - Benzinga

Mar 09, 2026
pulisher
Mar 07, 2026

How Denali Therapeutics Inc. stock reacts to global recession fearsPortfolio Risk Report & Stock Market Timing Techniques - Naître et grandir

Mar 07, 2026
pulisher
Mar 07, 2026

DNLI Posts Narrower-Than-Expected Q3 Loss, Advances MPS IIIA Drug - MSN

Mar 07, 2026
pulisher
Mar 07, 2026

(DNLI) Price Dynamics and Execution-Aware Positioning - Stock Traders Daily

Mar 07, 2026

Denali Therapeutics Inc Stock (DNLI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$27.09
price down icon 1.13%
$47.08
price up icon 3.03%
$52.88
price up icon 3.11%
$87.70
price down icon 0.90%
ONC ONC
$272.99
price down icon 1.11%
$147.84
price up icon 6.51%
Cap:     |  Volume (24h):