30.34
price down icon4.75%   -1.45
 
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Upstream Bio Inc stock is traded at $30.34, with a volume of 116.05K. It is down -4.75% in the last 24 hours and up +3.66% over the past month. Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.
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Previous Close:
$31.79
Open:
$31.62
24h Volume:
116.05K
Relative Volume:
0.23
Market Cap:
$1.63B
Revenue:
$2.22M
Net Income/Loss:
$-40.51M
P/E Ratio:
-23.62
EPS:
-1.2847
Net Cash Flow:
$-46.53M
1W Performance:
-2.32%
1M Performance:
+3.66%
6M Performance:
+162.62%
1Y Performance:
+181.15%
1-Day Range:
Value
$30.13
$31.62
1-Week Range:
Value
$29.08
$32.52
52-Week Range:
Value
$5.14
$33.68

Upstream Bio Inc Stock (UPB) Company Profile

Name
Name
Upstream Bio Inc
Name
Phone
781-208-2466
Name
Address
890 WINTER STREET, SUITE 200, WALTHAM
Name
Employee
0
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
UPB's Discussions on Twitter

Compare UPB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
UPB
Upstream Bio Inc
30.23 1.72B 2.22M -40.51M -46.53M -1.2847
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
463.63 118.58B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
749.34 79.40B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ARGX
Argen X Se Adr
811.57 51.18B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
360.84 48.88B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
339.19 37.49B 4.98B 69.59M 525.67M 0.5197

Upstream Bio Inc Stock (UPB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-18-25 Initiated Mizuho Outperform
Nov-18-25 Initiated Evercore ISI Outperform
Oct-14-25 Initiated Truist Buy
Nov-05-24 Initiated JP Morgan Overweight
Nov-05-24 Initiated Piper Sandler Overweight
Nov-05-24 Initiated TD Cowen Buy
Nov-05-24 Initiated William Blair Outperform
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Upstream Bio Inc Stock (UPB) Latest News

pulisher
Jan 20, 2026

Will Upstream Bio Inc. stock attract ESG investorsBlue Chip Stock Analysis & Get Ahead with Our Profit-Packed Picks - bollywoodhelpline.com

Jan 20, 2026
pulisher
Jan 19, 2026

Aug Setups: What is the next catalyst for Upstream Bio IncEarnings Summary Report & Scalable Portfolio Growth Methods - baoquankhu1.vn

Jan 19, 2026
pulisher
Jan 19, 2026

Aug Levels: Is CSGS forming bullish engulfing patterns2025 Earnings Impact & Consistent Profit Alerts - baoquankhu1.vn

Jan 19, 2026
pulisher
Jan 16, 2026

Sectors Review: Is Upstream Bio Inc a cyclical or defensive stockTake Profit & Community Verified Trade Alerts - baoquankhu1.vn

Jan 16, 2026
pulisher
Jan 16, 2026

Why Upstream Bio (UPB) Is Up 12.2% After JPM Debut And VALINAT Hopes - simplywall.st

Jan 16, 2026
pulisher
Jan 15, 2026

Can Upstream Bio Inc outperform in the next rallyWeekly Trading Summary & Long-Term Growth Stock Strategies - baoquankhu1.vn

Jan 15, 2026
pulisher
Jan 15, 2026

Upstream Bio stock hits all-time high at 33.05 USD By Investing.com - Investing.com Nigeria

Jan 15, 2026
pulisher
Jan 14, 2026

Aug Volume: Is Upstream Bio Inc a defensive stockMarket Risk Summary & Reliable Price Breakout Alerts - baoquankhu1.vn

Jan 14, 2026
pulisher
Jan 14, 2026

Upstream Bio (NASDAQ:UPB) Reaches New 52-Week HighHere's What Happened - MarketBeat

Jan 14, 2026
pulisher
Jan 13, 2026

US Market Recap: Can Upstream Bio Inc ride the EV wave2025 Price Action Summary & AI Forecasted Entry/Exit Points - baoquankhu1.vn

Jan 13, 2026
pulisher
Jan 12, 2026

Positioning Upstream Bio for Commercial Success: Buy Rating on UPB Driven by Physician Enthusiasm and Long-Acting TSLP Opportunity Ahead of VALINAT Readout - TipRanks

Jan 12, 2026
pulisher
Jan 12, 2026

Upstream Bio, Inc. (NASDAQ:UPB) Receives Average Recommendation of "Moderate Buy" from Analysts - MarketBeat

Jan 12, 2026
pulisher
Jan 12, 2026

Upstream Bio, Inc. (NASDAQ:UPB) Receives Average Recommendation of “Moderate Buy” from Analysts - Defense World

Jan 12, 2026
pulisher
Jan 10, 2026

Upstream Bio’s Verekitug Study: A Potential Game-Changer for Severe Asthma Treatment - MSN

Jan 10, 2026
pulisher
Jan 09, 2026

Fed Watch: Is Upstream Bio Inc stock a bargain at current levelsJuly 2025 Final Week & Weekly Hot Stock Watchlists - Bộ Nội Vụ

Jan 09, 2026
pulisher
Jan 09, 2026

Is Upstream Bio Inc. stock vulnerable to regulatory risks2025 Technical Patterns & Weekly Top Gainers Alerts - Улправда

Jan 09, 2026
pulisher
Jan 08, 2026

How Upstream Bio Inc. stock reacts to Fed rate cutsMarket Growth Report & Free Community Consensus Stock Picks - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Will Upstream Bio Inc. stock maintain dividend yield2025 Trading Recap & Weekly Stock Breakout Alerts - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Is Upstream Bio Inc. stock a bargain at current levelsMarket Performance Summary & Stepwise Swing Trade Plans - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Upstream Bio: Fully Priced After Recent Rally (NASDAQ:UPB) - Seeking Alpha

Jan 08, 2026
pulisher
Jan 08, 2026

How Invesco Quality Municipal Income Trust stock performs after earningsMarket Sentiment Review & Technical Buy Zone Confirmations - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Is National Vision Holdings Inc. stock positioned for long term growthTrade Exit Summary & Daily Price Action Insights - Улправда

Jan 08, 2026
pulisher
Jan 07, 2026

Upstream Bio (NASDAQ:UPB) Trading 7.8% HigherTime to Buy? - MarketBeat

Jan 07, 2026
pulisher
Jan 07, 2026

Will Upstream Bio Inc. stock rally after Fed decisionsTrading Volume Surges & Free High Yield Market Plays - Улправда

Jan 07, 2026
pulisher
Jan 06, 2026

Upstream Bio initiated with an Outperform at LifeSci Capital - MSN

Jan 06, 2026
pulisher
Jan 05, 2026

Upstream Bio (NASDAQ:UPB) Stock Price Down 6.2%What's Next? - MarketBeat

Jan 05, 2026
pulisher
Jan 05, 2026

Upstream Bio to Present at the 44th Annual J.P. Morgan Healthcare Conference - GlobeNewswire

Jan 05, 2026
pulisher
Jan 02, 2026

Upstream Bio Inc Stock Price ($UPB), Quote & News - eToro

Jan 02, 2026
pulisher
Jan 01, 2026

Upstream Bio initiated with an outperform at Mizuho - MSN

Jan 01, 2026
pulisher
Dec 31, 2025

AI Indicators Detect Buy Opportunity in Zenith Drugs LimitedCash Flow Trends & Outstanding Investment Returns - earlytimes.in

Dec 31, 2025
pulisher
Dec 31, 2025

Geopolitics Watch: How Upstream Bio Inc stock reacts to Fed rate cutsWeekly Market Report & Fast Momentum Entry Tips - moha.gov.vn

Dec 31, 2025
pulisher
Dec 30, 2025

Upstream Bio (NASDAQ:UPB) Shares Down 3.4%Time to Sell? - MarketBeat

Dec 30, 2025
pulisher
Dec 29, 2025

Treasury Yields: How Upstream Bio Inc stock reacts to global recession fearsBuy Signal & Reliable Breakout Forecasts - moha.gov.vn

Dec 29, 2025
pulisher
Dec 26, 2025

Upstream Bio Reports Progress in Respiratory Trials - MSN

Dec 26, 2025
pulisher
Dec 24, 2025

Upstream Bio (NASDAQ:UPB) Stock Price Up 4.8%Should You Buy? - MarketBeat

Dec 24, 2025
pulisher
Dec 23, 2025

Upstream Bio (UPB) price target decreased by 18.03% to 51.00 - MSN

Dec 23, 2025
pulisher
Dec 23, 2025

Upstream Bio (UPB): NASDAQ Biotech Index Entry Sparks the Big Rerating Debate - parameter.io

Dec 23, 2025
pulisher
Dec 21, 2025

Upstream Bio, Inc.(NasdaqGS: UPB) added to NASDAQ Biotechnology Index - marketscreener.com

Dec 21, 2025
pulisher
Dec 21, 2025

Upstream Bio, Inc. (UPB) Eps Diluted (Quarterly) - Zacks Investment Research

Dec 21, 2025
pulisher
Dec 21, 2025

Upstream Bio, Inc. (NASDAQ:UPB) Receives $45.25 Average Price Target from Brokerages - Defense World

Dec 21, 2025
pulisher
Dec 20, 2025

Can Upstream Bio Inc. stock weather global recessionPortfolio Risk Report & Accurate Entry and Exit Point Alerts - Улправда

Dec 20, 2025
pulisher
Dec 20, 2025

Why retail investors favor Upstream Bio Inc. stockWeekly Risk Summary & Low Volatility Stock Suggestions - Улправда

Dec 20, 2025
pulisher
Dec 20, 2025

Does Mizuho’s New Coverage of Upstream Bio (UPB) Reframe the Stock’s Risk‑Reward Narrative? - Sahm

Dec 20, 2025
pulisher
Dec 19, 2025

How Upstream Bio Inc. stock reacts to global recession fearsNew Guidance & Risk Controlled Swing Alerts - DonanımHaber

Dec 19, 2025
pulisher
Dec 19, 2025

Will Upstream Bio Inc. stock beat EPS estimatesEarnings Growth Summary & Risk Adjusted Swing Trade Ideas - Улправда

Dec 19, 2025
pulisher
Dec 19, 2025

Upstream Bio (NASDAQ:UPB) Stock Rating Upgraded by Mizuho - MarketBeat

Dec 19, 2025
pulisher
Dec 19, 2025

Would You Still Hold Upstream Bio Stock If It Fell 30%? - Trefis

Dec 19, 2025
pulisher
Dec 19, 2025

Is Upstream Bio Inc. stock overvalued by current metricsTrade Analysis Summary & Weekly Sector Rotation Insights - Улправда

Dec 19, 2025
pulisher
Dec 19, 2025

How Upstream Bio Inc. stock reacts to inflationary pressures2025 Sector Review & Risk Managed Investment Strategies - DonanımHaber

Dec 19, 2025
pulisher
Dec 18, 2025

Will Upstream Bio Inc. stock benefit from green energy trends2025 Top Gainers & Expert-Curated Trade Recommendations - Улправда

Dec 18, 2025
pulisher
Dec 18, 2025

Chipmakers Recap: Can Upstream Bio Inc. stock weather global recessionJuly 2025 Levels & Low Risk Investment Opportunities - Улправда

Dec 18, 2025

Upstream Bio Inc Stock (UPB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$100.60
price down icon 4.38%
$33.77
price up icon 1.95%
$118.82
price up icon 0.01%
$116.03
price down icon 2.22%
$155.69
price down icon 3.02%
biotechnology ONC
$338.76
price down icon 0.05%
Cap:     |  Volume (24h):