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7.86
6.22%
0.46
After Hours:
7.86
Upstream Bio Inc stock is traded at $7.86, with a volume of 726.03K.
It is up +6.22% in the last 24 hours and up +11.49% over the past month.
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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Previous Close:
$7.40
Open:
$7.48
24h Volume:
726.03K
Relative Volume:
1.21
Market Cap:
$427.74M
Revenue:
$3.32M
Net Income/Loss:
$-156.76M
P/E Ratio:
-2.7086
EPS:
-2.9019
Net Cash Flow:
$-140.13M
1W Performance:
+13.58%
1M Performance:
+11.49%
6M Performance:
-72.01%
1Y Performance:
-28.42%
1-Day Range:
$7.32
$8.00
1-Week Range:
$6.81
$8.00
52-Week Range:
$5.85
$33.68
Upstream Bio Inc Stock (UPB) Company Profile
Name
Upstream Bio Inc
Sector
Industry
Phone
781-208-2466
Address
890 WINTER STREET, SUITE 200, WALTHAM
Compare UPB vs VRTX, REGN, ARGX, ALNY, RVMD
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
UPB
Upstream Bio Inc
|
7.86 | 402.71M | 3.32M | -156.76M | -140.13M | -2.9019 |
VRTX
Vertex Pharmaceuticals Inc
|
522.25 | 134.41B | 12.34B | 4.34B | 3.71B | 16.87 |
REGN
Regeneron Pharmaceuticals Inc
|
676.23 | 68.13B | 14.92B | 4.42B | 3.79B | 41.04 |
ARGX
Argen X Se Adr
|
919.94 | 57.01B | 4.16B | 1.29B | 734.26M | 19.58 |
ALNY
Alnylam Pharmaceuticals Inc
|
321.59 | 41.79B | 4.29B | 577.22M | 641.34M | 4.2086 |
RVMD
Revolution Medicines Inc
|
190.46 | 40.39B | 742.00K | -1.37B | -1.07B | -7.0731 |
Upstream Bio Inc Stock (UPB) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Mar-27-26 | Downgrade | Evercore ISI | Outperform → In-line |
| Dec-18-25 | Initiated | Mizuho | Outperform |
| Nov-18-25 | Initiated | Evercore ISI | Outperform |
| Oct-14-25 | Initiated | Truist | Buy |
| Nov-05-24 | Initiated | JP Morgan | Overweight |
| Nov-05-24 | Initiated | Piper Sandler | Overweight |
| Nov-05-24 | Initiated | TD Cowen | Buy |
| Nov-05-24 | Initiated | William Blair | Outperform |
View All
Upstream Bio Inc Stock (UPB) Latest News
Price to book forward of Upstream Bio, Inc. – NASDAQ:UPB - TradingView
UPBUpstream Bio Inc Dividends - Finviz
Here's Why We're Watching Upstream Bio's (NASDAQ:UPB) Cash Burn Situation - Moomoo
Enterprise value to EBIT forward of Upstream Bio, Inc. – NASDAQ:UPB - TradingView
UpStream Bio(UPB) Stock Options Chain | Quotes & News - Moomoo
Why Did UPB Stock Plunge 40% Today? - Stocktwits
UPB News | UPSTREAM BIO INC (NASDAQ:UPB) - ChartMill
Upstream Bio, Inc. (UPB) reports Q1 loss, beats revenue estimates - MSN
Upstream Bio, Inc. Actuals & Estimates (NASDAQ:UPB) - TradingView
Upstream Bio, Inc. Actuals & Estimates (BOATS:UPB) - TradingView
UPB Forecast — Price Target — Prediction for 2027 - TradingView
Is Upstream Bio, Inc. (UPB) a Rising Biotech Opportunity After New Analyst Coverage? - Insider Monkey
Enterprise value to EBITDA forward of Upstream Bio, Inc. – NASDAQ:UPB - TradingView
JPMorgan Cuts Upstream Bio Stock Target to Eight Dollars - sekbernews.id
Is Upstream Bio, Inc. (UPB) the Best Low Priced Stocks to Get Rich in 2026? - Yahoo Finance
Upstream Bio Inc (UPB) Earnings Forecast: Future EPS & Revenue Growth Estimates - TradingKey
UPB Technical Analysis & Stock Price Forecast - Intellectia AI
Upstream Bio Inc (UPB) Valuation: PE, PB & Fair Value Analysis - TradingKey
Upstream Bio Inc (UPB) Shareholder Structure: Major Shareholders & Institutional Holdings - TradingKey
Upstream Bio Inc (UPB) Institutional Confidence - TradingKey
Top Executive Makes Strategic Move With Upstream Bio Stock - TipRanks
Upstream Bio Inc (UPB) Dividends & Stock Splits: Historical Payouts and Event Timeline - TradingKey
Upstream Bio Inc (UPB) Revenue Breakdown: Business Segments, Regional Revenue & Profit Contribution - TradingKey
Upstream Bio Inc (UPB) Financial Health: Profitability & Balance Sheet Analysis - TradingKey
Upstream Bio Inc (UPB) Risk Assessment: Volatility, Financial Risk & Investment Risk - TradingKey
Upstream Bio Inc (UPB) Technical Analysis: Support, Resistance, Indicators & Moving Averages - TradingKey
Upstream Bio presents positive Phase 2 trial data for verekitug By Investing.com - Investing.com Nigeria
Upstream Bio presents positive Phase 2 trial data for verekitug - Investing.com
Upstream Bio, Inc. unveils Phase 2 VIBRANT trial data showing majority of verekitug recipients achieve key improvements - Traders Union
Upstream Bio Reports Positive Phase 2 Results for Verekitug in Chronic Rhinosinusitis with Nasal Polyps, Achieving Clinically Meaningful Improvements in Key Symptoms - Quiver Quantitative
Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements ... - Caledonian Record
Upstream Bio Presents New Responder Analyses Demonstrating - GlobeNewswire
Upstream Bio Inc. (UPB) Falls 4.39% as Shares Test Key Support LevelGamma Exposure - newsline.com
UPB Q1 2026 Earnings: Narrower-than-Expected Loss as Clinical Progress ContinuesEstimate Accuracy - newsline.com
Upstream Bio Cut to Neutral From Overweight by JP Morgan - Moomoo
Upstream Bio lead drug pivotal trial plan follows strong phase 2 data - MSN
JPMorgan Downgrades Upstream Bio to Neutral From Overweight, Cuts Price Target to $8 From $35 - marketscreener.com
JPMorgan downgrades Upstream Bio stock rating on execution risks By Investing.com - Investing.com Australia
J.P. Morgan Downgrades UpStream Bio(UPB.US) to Hold Rating, Announces Target Price $8 - Moomoo
Upstream Bio Shareholders Elect Directors, Ratify 2026 Auditor - The Globe and Mail
Upstream Bio, Inc. leadership to share strategy at major Goldman Sachs event - Traders Union
Upstream Bio (UPB) Declines 3.6%: Support at $6.13 in Focus After Selling PressureParabolic SAR - dars.gov.et
Upstream Bio (UPB) Declines 4% as Shares Approach Key Support at $6.42Thematic ETF Flow - newsline.com
Upstream Bio to Showcase Additional Efficacy Data from the Phase 2 VIBRANT Trial of Verekitug in CRSwNP in Oral Session at EAACI 2026 - markets.businessinsider.com
Upstream Bio to present verekitug trial data at medical congress By Investing.com - Investing.com Australia
Upstream Bio Inc Stock (UPB) Financials Data
Revenue
Net Income
Cash Flow
EPS
Upstream Bio Inc Stock (UPB) Insider Trading
| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total |
|---|---|---|---|---|---|---|---|
| Sutherland Everett Rand | Chief Executive Officer |
Jun 16 '26 |
Sale |
6.10 |
2,095 |
12,780 |
70,812 |
| Houghton Adam | Chief Business Officer |
Jun 16 '26 |
Sale |
6.10 |
700 |
4,270 |
23,601 |
| Deykin Aaron | Chief Medical Officer |
Jun 16 '26 |
Sale |
6.10 |
895 |
5,460 |
33,197 |
| Ambrose Allison | General Counsel |
Jun 16 '26 |
Sale |
6.10 |
477 |
2,910 |
16,048 |
| GRAY MICHAEL | CFO and COO |
Mar 16 '26 |
Sale |
9.29 |
852 |
7,915 |
29,648 |
| Deykin Aaron | Chief Medical Officer |
Mar 16 '26 |
Sale |
9.29 |
894 |
8,305 |
32,687 |
| Sutherland Everett Rand | Chief Executive Officer |
Mar 16 '26 |
Sale |
9.29 |
2,093 |
19,444 |
72,907 |
| Ambrose Allison | General Counsel |
Mar 16 '26 |
Sale |
9.29 |
475 |
4,413 |
16,525 |
| Houghton Adam | Chief Business Officer |
Mar 16 '26 |
Sale |
9.29 |
699 |
6,494 |
24,301 |
1.17%
2.48%
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