12.80
price down icon12.87%   -1.89
after-market After Hours: 12.66 -0.14 -1.09%
loading
Upstream Bio Inc stock is traded at $12.80, with a volume of 3.87M. It is down -12.87% in the last 24 hours and down -59.57% over the past month. Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.
See More
Previous Close:
$14.69
Open:
$14.86
24h Volume:
3.87M
Relative Volume:
5.15
Market Cap:
$691.69M
Revenue:
$2.22M
Net Income/Loss:
$-40.51M
P/E Ratio:
-9.9634
EPS:
-1.2847
Net Cash Flow:
$-46.53M
1W Performance:
-50.77%
1M Performance:
-59.57%
6M Performance:
-26.86%
1Y Performance:
+78.77%
1-Day Range:
Value
$12.75
$14.86
1-Week Range:
Value
$12.65
$28.57
52-Week Range:
Value
$5.14
$33.68

Upstream Bio Inc Stock (UPB) Company Profile

Name
Name
Upstream Bio Inc
Name
Phone
781-208-2466
Name
Address
890 WINTER STREET, SUITE 200, WALTHAM
Name
Employee
0
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
UPB's Discussions on Twitter

Compare UPB vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
UPB
Upstream Bio Inc
12.80 793.83M 2.22M -40.51M -46.53M -1.2847
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
465.02 117.03B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
783.65 82.35B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
833.54 51.64B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
308.48 42.58B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
346.42 38.87B 4.98B 69.60M 525.67M 0.5198

Upstream Bio Inc Stock (UPB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-18-25 Initiated Mizuho Outperform
Nov-18-25 Initiated Evercore ISI Outperform
Oct-14-25 Initiated Truist Buy
Nov-05-24 Initiated JP Morgan Overweight
Nov-05-24 Initiated Piper Sandler Overweight
Nov-05-24 Initiated TD Cowen Buy
Nov-05-24 Initiated William Blair Outperform
View All

Upstream Bio Inc Stock (UPB) Latest News

pulisher
05:19 AM

Upstream Bio (NASDAQ:UPB) Trading Down 10.3%Time to Sell? - MarketBeat

05:19 AM
pulisher
01:50 AM

Upstream Bio: Hold Rating As Verekitug Faces Competition Among Latest Asthma Data (UPB) - Seeking Alpha

01:50 AM
pulisher
08:06 AM

Upstream Bio’s stock drops 47% on verekitug Phase II asthma data - Clinical Trials Arena

08:06 AM
pulisher
Feb 11, 2026

Upstream To Upgrade Verekitug To Phase III After Positive Asthma Results - Citeline News & Insights

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio (NASDAQ:UPB) Shares Gap DownHere's Why - MarketBeat

Feb 11, 2026
pulisher
Feb 11, 2026

VALIANT: Verekitug Reduces Average Annual Asthma Flare-Ups in Phase 2 Trial - HCPLive

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio battered despite positive new verekitug data - The Pharma Letter

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Reports Positive Phase 2 Verekitug Asthma Results - TipRanks

Feb 11, 2026
pulisher
Feb 11, 2026

UPB: Verekitug cut severe asthma exacerbations by up to 56% with durable efficacy and infrequent dosing - TradingView

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Faces New Strategic Challenges Amid Latest Developments - timothysykes.com

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio stock tumbles after mixed Phase 2 asthma trial results - Investing.com Canada

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio plunges as asthma drug misses 'home run' bar - TradingView

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio posts mid-stage asthma trial win (UPB:NASDAQ) - Seeking Alpha

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio shares plunge 20% premarket after co reports mid-stage asthma drug trial data - marketscreener.com

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio reports positive top-line results from the phase 2 Valiant trial of Verekitug for the treatment of severe asthma - marketscreener.com

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Reports Positive Phase 2 Severe Asthma Data - TipRanks

Feb 11, 2026
pulisher
Feb 11, 2026

Why Did UPB Stock Pop 20% In Pre-Market Today? - Mena FN

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio, Inc. Reports Positive Phase 2 VALIANT Trial Results for Verekitug - TradingView

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Stock Pre-Market (+15%) : Positive Phase 2 Asthma Trial Data - Trefis

Feb 11, 2026
pulisher
Feb 11, 2026

UPB: Verekitug showed robust efficacy and safety in severe asthma, advancing to Phase 3 trials - TradingView

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Reports Positive Top-Line Results From The Phase 2 Valiant Trial Of Verekitug For The Treatment Of Severe Asthma - TradingView

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio Reports Positive Top-line Results from the - GlobeNewswire

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio to report verekitug phase 2 trial results for severe asthma - Investing.com Canada

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio To Present Phase 2 VALIANT Trial Results In Severe Asthma, Today - Nasdaq

Feb 11, 2026
pulisher
Feb 11, 2026

Upstream Bio to report verekitug phase 2 trial results for severe asthma By Investing.com - Investing.com South Africa

Feb 11, 2026
pulisher
Feb 10, 2026

Upstream Bio to reveal Phase 2 trial results for asthma drug - Traders Union

Feb 10, 2026
pulisher
Feb 10, 2026

Upstream Bio to Host Webcast to Report Top-Line Results - GlobeNewswire

Feb 10, 2026
pulisher
Feb 10, 2026

Upstream Bio (NASDAQ:UPB) Stock Price Up 9.4%Here's What Happened - MarketBeat

Feb 10, 2026
pulisher
Feb 09, 2026

Severe Asthma Clinical Trial Analysis: In-Depth Analysis of 50+ - openPR.com

Feb 09, 2026
pulisher
Feb 09, 2026

Upstream Bio, Inc. (NASDAQ:UPB) Receives $45.25 Consensus PT from Brokerages - Defense World

Feb 09, 2026
pulisher
Feb 06, 2026

Upstream Bio, Inc. (NASDAQ:UPB) Receives Consensus Rating of "Moderate Buy" from Analysts - MarketBeat

Feb 06, 2026
pulisher
Feb 05, 2026

Upstream Bio (NASDAQ:UPB) Stock Price Down 4.6%Should You Sell? - MarketBeat

Feb 05, 2026
pulisher
Feb 04, 2026

Generate Biomedicines, Clinical-Stage Generative Biology Company Designing AI-Engineered Protein Therapeutics, Files for Nasdaq IPO - TradingView

Feb 04, 2026
pulisher
Jan 31, 2026

Analysts Offer Insights on Healthcare Companies: Upstream Bio, Inc. (UPB) and BillionToOne, Inc. Class A (BLLN) - The Globe and Mail

Jan 31, 2026
pulisher
Jan 28, 2026

Analyst Downgrade: Whats next for Upstream Bio Inc stockWeekly Stock Recap & Reliable Momentum Entry Alerts - baoquankhu1.vn

Jan 28, 2026
pulisher
Jan 27, 2026

Stop Loss: What is the next catalyst for Upstream Bio IncChart Signals & Low Risk Entry Point Tips - baoquankhu1.vn

Jan 27, 2026
pulisher
Jan 27, 2026

Analysts Are Bullish on These Healthcare Stocks: Guardant Health (GH), Regeneron (REGN) - The Globe and Mail

Jan 27, 2026
pulisher
Jan 23, 2026

Upstream Bio, Inc. (UPB) Stock Analysis: Potential 49.64% Upside Amid Strong Buy Ratings - DirectorsTalk Interviews

Jan 23, 2026
pulisher
Jan 21, 2026

Upstream Bio’s Verekitug Study: A Potential Game-Changer for Severe Asthma Treatment - MSN

Jan 21, 2026
pulisher
Jan 20, 2026

Will Upstream Bio Inc. stock attract ESG investorsBlue Chip Stock Analysis & Get Ahead with Our Profit-Packed Picks - bollywoodhelpline.com

Jan 20, 2026
pulisher
Jan 19, 2026

Aug Setups: What is the next catalyst for Upstream Bio IncEarnings Summary Report & Scalable Portfolio Growth Methods - baoquankhu1.vn

Jan 19, 2026
pulisher
Jan 19, 2026

Aug Levels: Is CSGS forming bullish engulfing patterns2025 Earnings Impact & Consistent Profit Alerts - baoquankhu1.vn

Jan 19, 2026
pulisher
Jan 17, 2026

Analysts Offer Insights on Healthcare Companies: Upstream Bio, Inc. (UPB) and BioNano Genomics (BNGO) - The Globe and Mail

Jan 17, 2026
pulisher
Jan 16, 2026

Sectors Review: Is Upstream Bio Inc a cyclical or defensive stockTake Profit & Community Verified Trade Alerts - baoquankhu1.vn

Jan 16, 2026
pulisher
Jan 16, 2026

Why Upstream Bio (UPB) Is Up 12.2% After JPM Debut And VALINAT Hopes - simplywall.st

Jan 16, 2026
pulisher
Jan 15, 2026

Can Upstream Bio Inc outperform in the next rallyWeekly Trading Summary & Long-Term Growth Stock Strategies - baoquankhu1.vn

Jan 15, 2026
pulisher
Jan 15, 2026

Upstream Bio stock hits all-time high at 33.05 USD By Investing.com - Investing.com Nigeria

Jan 15, 2026
pulisher
Jan 14, 2026

Aug Volume: Is Upstream Bio Inc a defensive stockMarket Risk Summary & Reliable Price Breakout Alerts - baoquankhu1.vn

Jan 14, 2026
pulisher
Jan 14, 2026

Upstream Bio (NASDAQ:UPB) Reaches New 52-Week HighHere's What Happened - MarketBeat

Jan 14, 2026
pulisher
Jan 14, 2026

Upstream Bio stock hits all-time high at 33.05 USD - Investing.com

Jan 14, 2026
pulisher
Jan 13, 2026

US Market Recap: Can Upstream Bio Inc ride the EV wave2025 Price Action Summary & AI Forecasted Entry/Exit Points - baoquankhu1.vn

Jan 13, 2026

Upstream Bio Inc Stock (UPB) Financials Data

Revenue

loading

Net Income

loading

Cash Flow

loading

EPS

loading
$44.80
price up icon 1.24%
$26.75
price down icon 0.19%
$100.75
price up icon 1.93%
$105.76
price down icon 3.31%
$146.17
price down icon 1.52%
biotechnology ONC
$346.42
price down icon 1.38%
Cap:     |  Volume (24h):