27.07
price down icon0.29%   -0.08
 
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Upstream Bio Inc stock is traded at $27.07, with a volume of 586.43K. It is down -0.29% in the last 24 hours and up +8.24% over the past month. Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.
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Previous Close:
$27.15
Open:
$27.3
24h Volume:
586.43K
Relative Volume:
1.25
Market Cap:
$1.46B
Revenue:
$2.22M
Net Income/Loss:
$-40.51M
P/E Ratio:
-21.07
EPS:
-1.2847
Net Cash Flow:
$-46.53M
1W Performance:
-8.18%
1M Performance:
+8.24%
6M Performance:
+143.22%
1Y Performance:
+66.07%
1-Day Range:
Value
$26.72
$28.01
1-Week Range:
Value
$26.72
$29.92
52-Week Range:
Value
$5.14
$33.00

Upstream Bio Inc Stock (UPB) Company Profile

Name
Name
Upstream Bio Inc
Name
Phone
781-208-2466
Name
Address
890 WINTER STREET, SUITE 200, WALTHAM
Name
Employee
0
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
UPB's Discussions on Twitter

Compare UPB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
UPB
Upstream Bio Inc
27.07 1.47B 2.22M -40.51M -46.53M -1.2847
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
452.13 115.03B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
776.31 81.12B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
400.17 52.54B 3.21B 43.57M 221.36M 0.2405
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ARGX
Argen X Se Adr
839.99 51.78B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
INSM
Insmed Inc
177.12 37.12B 447.02M -1.18B -906.14M -6.1812

Upstream Bio Inc Stock (UPB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-18-25 Initiated Mizuho Outperform
Nov-18-25 Initiated Evercore ISI Outperform
Oct-14-25 Initiated Truist Buy
Nov-05-24 Initiated JP Morgan Overweight
Nov-05-24 Initiated Piper Sandler Overweight
Nov-05-24 Initiated TD Cowen Buy
Nov-05-24 Initiated William Blair Outperform
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Upstream Bio Inc Stock (UPB) Latest News

pulisher
Jan 02, 2026

Upstream Bio Inc Stock Price ($UPB), Quote & News - eToro

Jan 02, 2026
pulisher
Jan 01, 2026

Upstream Bio initiated with an outperform at Mizuho - MSN

Jan 01, 2026
pulisher
Dec 31, 2025

AI Indicators Detect Buy Opportunity in Zenith Drugs LimitedCash Flow Trends & Outstanding Investment Returns - earlytimes.in

Dec 31, 2025
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Dec 31, 2025

Geopolitics Watch: How Upstream Bio Inc stock reacts to Fed rate cutsWeekly Market Report & Fast Momentum Entry Tips - moha.gov.vn

Dec 31, 2025
pulisher
Dec 30, 2025

Upstream Bio (NASDAQ:UPB) Shares Down 3.4%Time to Sell? - MarketBeat

Dec 30, 2025
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Dec 29, 2025

Treasury Yields: How Upstream Bio Inc stock reacts to global recession fearsBuy Signal & Reliable Breakout Forecasts - moha.gov.vn

Dec 29, 2025
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Dec 26, 2025

Upstream Bio Reports Progress in Respiratory Trials - MSN

Dec 26, 2025
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Dec 24, 2025

Upstream Bio (NASDAQ:UPB) Stock Price Up 4.8%Should You Buy? - MarketBeat

Dec 24, 2025
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Dec 23, 2025

Upstream Bio (UPB) price target decreased by 18.03% to 51.00 - MSN

Dec 23, 2025
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Dec 23, 2025

Upstream Bio (UPB): NASDAQ Biotech Index Entry Sparks the Big Rerating Debate - parameter.io

Dec 23, 2025
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Dec 21, 2025

Upstream Bio, Inc.(NasdaqGS: UPB) added to NASDAQ Biotechnology Index - marketscreener.com

Dec 21, 2025
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Dec 21, 2025

Upstream Bio, Inc. (NASDAQ:UPB) Receives $45.25 Average Price Target from Brokerages - Defense World

Dec 21, 2025
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Dec 20, 2025

Can Upstream Bio Inc. stock weather global recessionPortfolio Risk Report & Accurate Entry and Exit Point Alerts - Улправда

Dec 20, 2025
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Dec 20, 2025

Why retail investors favor Upstream Bio Inc. stockWeekly Risk Summary & Low Volatility Stock Suggestions - Улправда

Dec 20, 2025
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Dec 20, 2025

Does Mizuho’s New Coverage of Upstream Bio (UPB) Reframe the Stock’s Risk‑Reward Narrative? - Sahm

Dec 20, 2025
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Dec 19, 2025

How Upstream Bio Inc. stock reacts to global recession fearsNew Guidance & Risk Controlled Swing Alerts - DonanımHaber

Dec 19, 2025
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Dec 19, 2025

Will Upstream Bio Inc. stock beat EPS estimatesEarnings Growth Summary & Risk Adjusted Swing Trade Ideas - Улправда

Dec 19, 2025
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Dec 19, 2025

Upstream Bio (NASDAQ:UPB) Stock Rating Upgraded by Mizuho - MarketBeat

Dec 19, 2025
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Dec 19, 2025

Is Upstream Bio Inc. stock overvalued by current metricsTrade Analysis Summary & Weekly Sector Rotation Insights - Улправда

Dec 19, 2025
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Dec 19, 2025

How Upstream Bio Inc. stock reacts to inflationary pressures2025 Sector Review & Risk Managed Investment Strategies - DonanımHaber

Dec 19, 2025
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Dec 19, 2025

Will Upstream Bio Inc. stock maintain dividend yieldQuarterly Earnings Summary & Free Real-Time Market Sentiment Alerts - DonanımHaber

Dec 19, 2025
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Dec 18, 2025

Will Upstream Bio Inc. stock benefit from green energy trends2025 Top Gainers & Expert-Curated Trade Recommendations - Улправда

Dec 18, 2025
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Dec 18, 2025

Chipmakers Recap: Can Upstream Bio Inc. stock weather global recessionJuly 2025 Levels & Low Risk Investment Opportunities - Улправда

Dec 18, 2025
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Dec 18, 2025

Upstream Bio, Inc. (NASDAQ:UPB) Given Average Rating of "Moderate Buy" by Brokerages - MarketBeat

Dec 18, 2025
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Dec 18, 2025

Mizuho Initiates Coverage on UPB with Outperform Rating and $51 PT | UPB Stock News - GuruFocus

Dec 18, 2025
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Dec 17, 2025

Mizuho initiates Upstream Bio stock with Outperform rating on asthma drug potential - Investing.com Canada

Dec 17, 2025
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Dec 17, 2025

Upstream Bio initiated with an Outperform at Mizuho - TipRanks

Dec 17, 2025
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Dec 16, 2025

Upstream Bio (NASDAQ:UPB) Stock Price Up 6.9%Time to Buy? - MarketBeat

Dec 16, 2025
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Dec 14, 2025

Financial Analysis: Precision BioSciences (NASDAQ:DTIL) & Upstream Bio (NASDAQ:UPB) - Defense World

Dec 14, 2025
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Dec 13, 2025

Bain Capital Life Sciences Investors LLC Raises Holdings in Upstream Bio, Inc. $UPB - MarketBeat

Dec 13, 2025
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Dec 10, 2025

Norges Bank Acquires New Position in Upstream Bio, Inc. $UPB - MarketBeat

Dec 10, 2025
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Dec 08, 2025

Can Upstream Bio Stock Hold Up When Markets Turn? - Trefis

Dec 08, 2025
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Dec 07, 2025

Contrasting Upstream Bio (UPB) & The Competition - Defense World

Dec 07, 2025
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Dec 06, 2025

Geode Capital Management LLC Buys 235,958 Shares of Upstream Bio, Inc. $UPB - MarketBeat

Dec 06, 2025
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Dec 05, 2025

Lifesci Capital Predicts Upstream Bio FY2025 Earnings - Defense World

Dec 05, 2025
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Dec 05, 2025

Upstream Bio: Maintaining Buy Rating On Verekitug Success In Phase 2 CRSwNP Study (UPB) - Seeking Alpha

Dec 05, 2025
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Dec 04, 2025

UPB: Virectib's robust phase 2 results and unique mechanism set the stage for pivotal trials in 2026 - TradingView

Dec 04, 2025
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Dec 04, 2025

Lifesci Capital Forecasts Upstream Bio FY2025 Earnings - MarketBeat

Dec 04, 2025
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Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Shares Down 8%Here's What Happened - MarketBeat

Dec 03, 2025
pulisher
Dec 03, 2025

Stocks of Upstream Bio Inc (UPB) are poised to climb above their peers - setenews.com

Dec 03, 2025
pulisher
Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Coverage Initiated by Analysts at Lifesci Capital - MarketBeat

Dec 03, 2025
pulisher
Dec 03, 2025

Upstream Bio (NASDAQ:UPB) Now Covered by Analysts at Lifesci Capital - Defense World

Dec 03, 2025
pulisher
Dec 02, 2025

LifeSci Capital Initiates Coverage of Upstream Bio (UPB) with Outperform Recommendation - Nasdaq

Dec 02, 2025
pulisher
Dec 02, 2025

Upstream Bio initiated with an Outperform at LifeSci Capital - TipRanks

Dec 02, 2025
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Dec 02, 2025

Is Upstream Bio Inc. stock attractive for ETFsJuly 2025 Snapshot & Fast Moving Stock Watchlists - Newser

Dec 02, 2025
pulisher
Nov 30, 2025

What analysts say about Upstream Bio Inc stockEarnings Miss Alerts & Free High Yield Market Plays - earlytimes.in

Nov 30, 2025
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Nov 28, 2025

Severe Asthma Clinical Pipeline 2025: A Comprehensive Review of 50+ Emerging Therapies from 40+ Innovators, says DelveInsight - Barchart.com

Nov 28, 2025
pulisher
Nov 26, 2025

You might want to take a look at Upstream Bio Inc (UPB) now - Setenews

Nov 26, 2025
pulisher
Nov 26, 2025

Upstream Bio (NASDAQ:UPB) Shares Up 8.5%Should You Buy? - MarketBeat

Nov 26, 2025
pulisher
Nov 25, 2025

Upstream Bio (UPB): Evaluating Valuation After 10% Share Price Surge - Yahoo Finance

Nov 25, 2025
pulisher
Nov 25, 2025

Promising Outlook for Upstream Bio, Inc. Driven by Verekitug’s Clinical Advancements - TipRanks

Nov 25, 2025

Upstream Bio Inc Stock (UPB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$38.86
price up icon 0.57%
$31.82
price up icon 3.31%
$101.42
price up icon 2.68%
$96.69
price up icon 1.57%
biotechnology ONC
$311.02
price up icon 2.37%
$177.12
price up icon 1.77%
Cap:     |  Volume (24h):