14.88
price down icon2.87%   -0.44
after-market After Hours: 14.88
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Spyre Therapeutics Inc stock is traded at $14.88, with a volume of 967.95K. It is down -2.87% in the last 24 hours and down -7.64% over the past month. Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$15.32
Open:
$15.46
24h Volume:
967.95K
Relative Volume:
1.71
Market Cap:
$898.77M
Revenue:
$688.00K
Net Income/Loss:
$-170.19M
P/E Ratio:
-5.027
EPS:
-2.96
Net Cash Flow:
$-154.68M
1W Performance:
-4.92%
1M Performance:
-7.64%
6M Performance:
-19.13%
1Y Performance:
-51.05%
1-Day Range:
Value
$14.63
$15.46
1-Week Range:
Value
$14.63
$15.84
52-Week Range:
Value
$10.91
$40.26

Spyre Therapeutics Inc Stock (SYRE) Company Profile

Name
Name
Spyre Therapeutics Inc
Name
Phone
(617) 651-5940
Name
Address
221 CRESCENT STREET, WALTHAM
Name
Employee
65
Name
Twitter
Name
Next Earnings Date
2024-11-07
Name
Latest SEC Filings
Name
SYRE's Discussions on Twitter

Compare SYRE with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SYRE
Spyre Therapeutics Inc
14.88 925.34M 688.00K -170.19M -154.68M -2.96
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
383.12 99.25B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
591.99 63.46B 14.21B 4.46B 3.56B 39.68
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
453.56 59.27B 2.46B -319.09M -52.09M -2.47
Biotechnology icon
ARGX
Argen X Se Adr
736.76 44.78B 3.06B 1.28B 447.35M 21.30
Biotechnology icon
ONC
Beone Medicines Ltd Adr
334.40 37.75B 3.81B -644.79M -669.77M -6.24

Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades

Date Action Analyst Rating Change
Apr-08-25 Initiated Leerink Partners Outperform
Mar-18-25 Initiated Wolfe Research Outperform
Sep-04-24 Initiated Wedbush Outperform
Jul-16-24 Initiated Evercore ISI Outperform
May-02-24 Initiated Robert W. Baird Outperform
Mar-01-24 Upgrade Wells Fargo Equal Weight → Overweight
Dec-20-23 Initiated BTIG Research Buy
Dec-11-23 Initiated Guggenheim Buy
Dec-11-23 Initiated Jefferies Buy
May-04-20 Initiated Piper Sandler Overweight
Mar-21-19 Initiated JP Morgan Overweight
Sep-04-18 Downgrade Wells Fargo Outperform → Market Perform
Apr-24-18 Initiated Evercore ISI Outperform
Mar-14-18 Reiterated Needham Buy
View All

Spyre Therapeutics Inc Stock (SYRE) Latest News

pulisher
03:25 AM

Goldman Sachs Group Inc. Reduces Stake in Spyre Therapeutics, Inc. $SYRE - Defense World

03:25 AM
pulisher
02:35 AM

Chart overlay techniques for tracking Spyre Therapeutics Inc.Stop Loss & Fast Gaining Stock Strategy Reports - newser.com

02:35 AM
pulisher
01:15 AM

Spyre Therapeutics (NASDAQ:SYRE) Stock Rating Lowered by Wall Street Zen - MarketBeat

01:15 AM
pulisher
Sep 19, 2025

Tools to monitor Spyre Therapeutics Inc. recovery probabilityPortfolio Value Report & Daily Technical Stock Forecast Reports - newser.com

Sep 19, 2025
pulisher
Sep 19, 2025

Published on: 2025-09-20 10:39:32 - khodrobank.com

Sep 19, 2025
pulisher
Sep 19, 2025

What does recent volatility data suggest for Spyre Therapeutics Inc.Quarterly Profit Report & Free Technical Pattern Based Buy Signals - newser.com

Sep 19, 2025
pulisher
Sep 19, 2025

Published on: 2025-09-19 15:19:15 - newser.com

Sep 19, 2025
pulisher
Sep 19, 2025

Does Spyre Therapeutics Inc. qualify in momentum factor screeningWeekly Trading Summary & Fast Gaining Stock Reports - newser.com

Sep 19, 2025
pulisher
Sep 19, 2025

CEO Change: Is Spyre Therapeutics Inc. gaining market share2025 Biggest Moves & Daily Profit Maximizing Tips - khodrobank.com

Sep 19, 2025
pulisher
Sep 19, 2025

Spyre Therapeutics (NASDAQ:SYRE) Trading Down 4.6%Time to Sell? - MarketBeat

Sep 19, 2025
pulisher
Sep 19, 2025

Update Report: What’s the RSI of Spyre Therapeutics Inc. stock2025 Macro Impact & Entry Point Confirmation Alerts - khodrobank.com

Sep 19, 2025
pulisher
Sep 18, 2025

How to use a screener to detect Spyre Therapeutics Inc. breakoutsWeekly Investment Report & Fast Momentum Entry Tips - newser.com

Sep 18, 2025
pulisher
Sep 18, 2025

Short Squeeze: How does Spyre Therapeutics Inc score in quality rankingsDay Trade & Smart Swing Trading Alerts - khodrobank.com

Sep 18, 2025
pulisher
Sep 18, 2025

Intelligent Development Could Make Spyre Therapeutics Best In Show - Seeking Alpha

Sep 18, 2025
pulisher
Sep 18, 2025

Using fundamentals and technicals on Spyre Therapeutics Inc.Weekly Gains Summary & Weekly Breakout Stock Alerts - newser.com

Sep 18, 2025
pulisher
Sep 18, 2025

Why Spyre Therapeutics Inc. is moving todayMarket Movers & Fast Gain Swing Trade Alerts - newser.com

Sep 18, 2025
pulisher
Sep 17, 2025

BTIG Research Reaffirms Buy Rating for Spyre Therapeutics (NASDAQ:SYRE) - MarketBeat

Sep 17, 2025
pulisher
Sep 17, 2025

Woodline Partners LP Boosts Position in Spyre Therapeutics, Inc. $SYRE - MarketBeat

Sep 17, 2025
pulisher
Sep 16, 2025

Can Spyre Therapeutics Inc maintain sales growthJuly 2025 Recap & Community Verified Swing Trade Signals - khodrobank.com

Sep 16, 2025
pulisher
Sep 16, 2025

Published on: 2025-09-16 12:08:18 - newser.com

Sep 16, 2025
pulisher
Sep 16, 2025

US Market Recap: Is Spyre Therapeutics Inc stock good for income investors2025 AllTime Highs & Weekly High Return Stock Opportunities - khodrobank.com

Sep 16, 2025
pulisher
Sep 16, 2025

Energy Moves: Will Spyre Therapeutics Inc benefit from current market trends2025 Market WrapUp & Reliable Volume Spike Alerts - khodrobank.com

Sep 16, 2025
pulisher
Sep 16, 2025

Spyre Therapeutics (SYRE): Analyst Reiterates Buy Rating | SYRE Stock News - GuruFocus

Sep 16, 2025
pulisher
Sep 16, 2025

Can you recover from losses in Spyre Therapeutics Inc.Quarterly Profit Review & Capital Efficiency Focused Strategies - newser.com

Sep 16, 2025
pulisher
Sep 16, 2025

Pullback Watch: Will Spyre Therapeutics Inc benefit from government policy2025 Biggest Moves & High Yield Equity Trading Tips - khodrobank.com

Sep 16, 2025
pulisher
Sep 16, 2025

Support Test: Is Spyre Therapeutics Inc benefiting from interest rate changesQuarterly Portfolio Report & Fast Moving Stock Trade Plans - خودرو بانک

Sep 16, 2025
pulisher
Sep 16, 2025

Growth Recap: Is Spyre Therapeutics Inc stock good for income investorsJuly 2025 Selloffs & Free Weekly Chart Analysis and Trade Guides - khodrobank.com

Sep 16, 2025
pulisher
Sep 16, 2025

Value Recap: Is Spyre Therapeutics Inc a top pick in the sectorJuly 2025 Trends & Weekly Consistent Profit Watchlists - خودرو بانک

Sep 16, 2025
pulisher
Sep 15, 2025

Is Spyre Therapeutics Inc. stock bottoming out2025 Bull vs Bear & Smart Money Movement Tracker - newser.com

Sep 15, 2025
pulisher
Sep 15, 2025

History Review: What are Spyre Therapeutics Inc.’s growth leversJuly 2025 Movers & AI Enhanced Execution Alerts - خودرو بانک

Sep 15, 2025
pulisher
Sep 15, 2025

What Fibonacci levels say about Spyre Therapeutics Inc. reboundBull Run & Fast Exit/Entry Strategy Plans - newser.com

Sep 15, 2025
pulisher
Sep 15, 2025

Spyre Therapeutics (SYRE) Doses First Patient In Promising SPY072 Phase 2 Trial - Yahoo Finance

Sep 15, 2025
pulisher
Sep 15, 2025

Spyre Therapeutics doses first patient in phase 2 rheumatic disease trial - Investing.com

Sep 15, 2025
pulisher
Sep 15, 2025

Spyre Flat on Test Result - Baystreet.ca

Sep 15, 2025
pulisher
Sep 15, 2025

Spyre Therapeutics doses first patient in phase 2 rheumatic disease trial By Investing.com - Investing.com South Africa

Sep 15, 2025
pulisher
Sep 15, 2025

Spyre doses first patient in phase 2 SKYWAY trial of SPY072, first anti-TL1A antibody for rheumatic diseases - MarketScreener

Sep 15, 2025
pulisher
Sep 15, 2025

First-Ever Anti-TL1A Drug for 3M+ Rheumatic Patients: Spyre's SPY072 Enters Phase 2 Trial - Stock Titan

Sep 15, 2025
pulisher
Sep 15, 2025

Detecting support and resistance levels for Spyre Therapeutics Inc.July 2025 Gainers & Technical Pattern Based Buy Signals - newser.com

Sep 15, 2025
pulisher
Sep 15, 2025

Automated trading signals detected on Spyre Therapeutics Inc.2025 Institutional Moves & Weekly Chart Analysis and Guides - newser.com

Sep 15, 2025

Spyre Therapeutics Inc Stock (SYRE) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$36.24
price up icon 1.43%
$86.53
price up icon 0.62%
$28.28
price up icon 0.86%
$96.22
price down icon 0.09%
$144.76
price down icon 0.75%
biotechnology ONC
$334.40
price down icon 2.48%
Cap:     |  Volume (24h):