12.65
price down icon10.22%   -1.435
 
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Spyre Therapeutics Inc stock is traded at $12.65, with a volume of 307.24K. It is down -10.22% in the last 24 hours and down -1.09% over the past month. Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$14.09
Open:
$13.84
24h Volume:
307.24K
Relative Volume:
0.47
Market Cap:
$849.28M
Revenue:
$1.23M
Net Income/Loss:
$-214.90M
P/E Ratio:
-3.07
EPS:
-4.1222
Net Cash Flow:
$-151.25M
1W Performance:
-15.78%
1M Performance:
-1.09%
6M Performance:
-66.25%
1Y Performance:
-64.64%
1-Day Range:
Value
$12.64
$14.28
1-Week Range:
Value
$12.66
$15.77
52-Week Range:
Value
$10.91
$40.49

Spyre Therapeutics Inc Stock (SYRE) Company Profile

Name
Name
Spyre Therapeutics Inc
Name
Phone
(617) 651-5940
Name
Address
221 CRESCENT STREET, WALTHAM
Name
Employee
65
Name
Twitter
Name
Next Earnings Date
2024-11-07
Name
Latest SEC Filings
Name
SYRE's Discussions on Twitter

Compare SYRE with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SYRE
Spyre Therapeutics Inc
12.64 849.28M 1.23M -214.90M -151.25M -4.1222
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
445.44 127.64B 11.02B -535.60M -978.00M -2.20
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
561.99 65.95B 14.09B 4.50B 2.96B 39.28
Biotechnology icon
ARGX
Argen X Se Adr
619.70 37.92B 2.19B 833.04M -1.28B 12.71
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
270.55 32.98B 2.35B -269.70M -75.39M -2.09
Biotechnology icon
ONC
Beigene Ltd Adr
241.44 26.92B 3.81B -644.79M -669.77M -6.24

Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades

Date Action Analyst Rating Change
Apr-08-25 Initiated Leerink Partners Outperform
Mar-18-25 Initiated Wolfe Research Outperform
Sep-04-24 Initiated Wedbush Outperform
Jul-16-24 Initiated Evercore ISI Outperform
May-02-24 Initiated Robert W. Baird Outperform
Mar-01-24 Upgrade Wells Fargo Equal Weight → Overweight
Dec-20-23 Initiated BTIG Research Buy
Dec-11-23 Initiated Guggenheim Buy
Dec-11-23 Initiated Jefferies Buy
May-04-20 Initiated Piper Sandler Overweight
Mar-21-19 Initiated JP Morgan Overweight
Sep-04-18 Downgrade Wells Fargo Outperform → Market Perform
Apr-24-18 Initiated Evercore ISI Outperform
Mar-14-18 Reiterated Needham Buy
View All

Spyre Therapeutics Inc Stock (SYRE) Latest News

pulisher
05:21 AM

Spyre Therapeutics (NASDAQ:SYRE) Given Outperform Rating at Wedbush - Defense World

05:21 AM
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01:34 AM

Brokerages Set Spyre Therapeutics, Inc. (NASDAQ:SYRE) PT at $49.57 - Defense World

01:34 AM
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May 05, 2025

Spyre Presents Promising SPY001 IBD Data And Combination Therapy Results At DDW 2025 - Nasdaq

May 05, 2025
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May 05, 2025

Spyre Therapeutics (SYRE) Showcases Promising IBD Treatment Data at Upcoming Conference | SYRE Stock News - GuruFocus

May 05, 2025
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May 05, 2025

Spyre Therapeutics Announces Poster Presentations at Digestive Disease Week (DDW) 2025 Including Up to Eight months of Follow-up from an Ongoing Phase 1 Trial of SPY001 | SYRE Stock News - GuruFocus

May 05, 2025
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May 05, 2025

Clinical Trial Shows 3X Longer Half-Life for Spyre IBD Drug vs Standard Treatment | SYRE Stock News - Stock Titan

May 05, 2025
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May 04, 2025

Invesco Ltd. Sells 118,195 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 04, 2025
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May 03, 2025

Wells Fargo & Company MN Purchases 6,908 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 03, 2025
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May 02, 2025

Spyre Therapeutics Announces Grants of Inducement Awards | SYRE Stock News - GuruFocus

May 02, 2025
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May 02, 2025

Spyre Therapeutics Awards 64,400 Shares in Stock Options to Strategic New Employee Hires - Stock Titan

May 02, 2025
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May 01, 2025

Spyre Therapeutics (SYRE) to Release Earnings on Thursday - Defense World

May 01, 2025
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May 01, 2025

Spyre Therapeutics Announces Grants of Inducement Awards - PR Newswire

May 01, 2025
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Apr 30, 2025

Barclays PLC Increases Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 30, 2025
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Apr 29, 2025

Analyzing Ratios: Arcutis Biotherapeutics Inc (ARQT)’s Financial Story Unveiled - DWinneX

Apr 29, 2025
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Apr 29, 2025

JPMorgan Chase & Co. Purchases 5,775 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 29, 2025
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Apr 24, 2025

Spyre Therapeutics Inc [SYRE] stock for 246,313 USD was sold by Albers Jeffrey W. - knoxdaily.com

Apr 24, 2025
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Apr 24, 2025

Are Smart Investors Making the Right Decision? Spyre Therapeutics Inc (SYRE) - Sete News

Apr 24, 2025
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Apr 23, 2025

Have you been able to find a good deal on Spyre Therapeutics Inc’s shares? - uspostnews.com

Apr 23, 2025
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Apr 22, 2025

Analyzing the Impact of Earnings Reports on Spyre Therapeutics Inc Inc. (SYRE) Price Performance - investchronicle.com

Apr 22, 2025
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Apr 19, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Purchased by Geode Capital Management LLC - The AM Reporter

Apr 19, 2025
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Apr 12, 2025

What is Leerink Partnrs’ Forecast for SYRE Q1 Earnings? - The AM Reporter

Apr 12, 2025
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Apr 11, 2025

Vanguard Group Inc. Buys 330,553 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 11, 2025
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Apr 11, 2025

Q1 Earnings Estimate for SYRE Issued By Leerink Partnrs - Defense World

Apr 11, 2025
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Apr 11, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Receives $50.33 Consensus Price Target from Brokerages - Defense World

Apr 11, 2025
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Apr 10, 2025

Corebridge Financial Inc. Has $401,000 Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 10, 2025
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Apr 10, 2025

Leerink Partnrs Upgrades Spyre Therapeutics (NASDAQ:SYRE) to “Strong-Buy” - Defense World

Apr 10, 2025
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Apr 09, 2025

KLP Kapitalforvaltning AS Invests $182,000 in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 09, 2025
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Apr 09, 2025

Spyre Therapeutics (NASDAQ:SYRE) Now Covered by Analysts at Leerink Partners - Defense World

Apr 09, 2025
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Apr 08, 2025

Leerink Partners Initiates Coverage of Spyre Therapeutics (SYRE) with Outperform Recommendation - Nasdaq

Apr 08, 2025
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Apr 08, 2025

Leerink Partners Initiates Spyre Therapeutics With Outperform Rating, $45 Price Target - marketscreener.com

Apr 08, 2025
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Apr 04, 2025

Biotech Spyre Therapeutics Awards 93,200 Stock Options in Key Talent Push - Stock Titan

Apr 04, 2025
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Apr 02, 2025

Spyre Therapeutics (NASDAQ:SYRE) Reaches New 52-Week LowHere's Why - MarketBeat

Apr 02, 2025
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Apr 02, 2025

Teacher Retirement System of Texas Takes Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 02, 2025
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Mar 30, 2025

Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Up – What’s Next? - Defense World

Mar 30, 2025
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Mar 29, 2025

Swiss National Bank Buys 19,000 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Mar 29, 2025
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Mar 28, 2025

Natixis Advisors LLC Purchases Shares of 17,300 Spyre Therapeutics, Inc. (NASDAQ:SYRE) - The AM Reporter

Mar 28, 2025
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Mar 27, 2025

Spyre Therapeutics Starts Dosing in Phase 1 Trial for IL-23 Antibody SPY003 - Marketscreener.com

Mar 27, 2025
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Mar 27, 2025

Spyre Therapeutics Announces First Participant Dosed in Phase 1 Trial of SPY003, its Novel Half-life Extended IL-23 Antibody - PR Newswire

Mar 27, 2025
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Mar 26, 2025

Head to Head Contrast: Spyre Therapeutics (NASDAQ:SYRE) & Aptorum Group (NASDAQ:APM) - Defense World

Mar 26, 2025
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Mar 23, 2025

Charles Schwab Investment Management Inc. Has $8.84 Million Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Mar 23, 2025
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Mar 22, 2025

Bank of New York Mellon Corp Decreases Stock Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Mar 22, 2025
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Mar 20, 2025

Will Spyre Therapeutics Redefine IBD Treatment With Superior Efficacy And Convenience? - RTTNews

Mar 20, 2025
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Mar 19, 2025

Spyre Therapeutics (NASDAQ:SYRE) Coverage Initiated by Analysts at Wolfe Research - Defense World

Mar 19, 2025
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Mar 18, 2025

Wolfe Research Initiates Spyre Therapeutics at Outperform With $27 Price Target -March 18, 2025 at 07:17 am EDT - Marketscreener.com

Mar 18, 2025
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Mar 16, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Acquired by Arizona State Retirement System - Defense World

Mar 16, 2025
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Mar 15, 2025

Victory Capital Management Inc. Takes Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Mar 15, 2025
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Mar 14, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Given Consensus Recommendation of “Buy” by Brokerages - Defense World

Mar 14, 2025
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Mar 07, 2025

Spyre Therapeutics Inc (SYRE) Announces Stock Option Grants to Non-Executive Employees - GuruFocus.com

Mar 07, 2025
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Mar 06, 2025

Rhumbline Advisers Boosts Holdings in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Mar 06, 2025
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Mar 04, 2025

Spyre Therapeutics Faces Compliance Hurdles After Transition from Smaller Reporting Company Status - MSN

Mar 04, 2025
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Mar 04, 2025

Spyre Therapeutics Inc (SYRE) deserves closer scrutiny - US Post News

Mar 04, 2025

Spyre Therapeutics Inc Stock (SYRE) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$67.95
price down icon 6.45%
$20.52
price down icon 4.75%
$32.08
price down icon 2.82%
$24.44
price down icon 12.81%
$92.57
price down icon 8.25%
biotechnology ONC
$242.04
price down icon 4.64%
Cap:     |  Volume (24h):