15.28
price down icon1.74%   -0.27
after-market After Hours: 15.28
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Spyre Therapeutics Inc stock is traded at $15.28, with a volume of 380.76K. It is down -1.74% in the last 24 hours and up +1.73% over the past month. Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$15.55
Open:
$15.5
24h Volume:
380.76K
Relative Volume:
0.58
Market Cap:
$922.15M
Revenue:
$1.23M
Net Income/Loss:
$-214.90M
P/E Ratio:
-3.7068
EPS:
-4.1222
Net Cash Flow:
$-151.25M
1W Performance:
+1.80%
1M Performance:
+1.73%
6M Performance:
-46.25%
1Y Performance:
-55.12%
1-Day Range:
Value
$14.75
$15.50
1-Week Range:
Value
$14.75
$15.71
52-Week Range:
Value
$10.91
$40.26

Spyre Therapeutics Inc Stock (SYRE) Company Profile

Name
Name
Spyre Therapeutics Inc
Name
Phone
(617) 651-5940
Name
Address
221 CRESCENT STREET, WALTHAM
Name
Employee
65
Name
Twitter
Name
Next Earnings Date
2024-11-07
Name
Latest SEC Filings
Name
SYRE's Discussions on Twitter

Compare SYRE with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SYRE
Spyre Therapeutics Inc
15.28 905.91M 1.23M -214.90M -151.25M -4.1222
Biotechnology icon
ONC
Beone Medicines Ltd Adr
245.58 26.10B 3.81B -644.79M -669.77M -6.24
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
442.05 111.96B 11.10B -988.90M -1.26B -3.92
Biotechnology icon
AKTX
Akari Therapeutics Plc Adr
1.35 42.96M 0 0 0 0.00
Biotechnology icon
VRNA
Verona Pharma Plc Adr
81.20 6.39B 0 -153.72M -103.81M -2.00
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
490.28 63.52B 14.09B 4.50B 2.96B 39.28

Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades

Date Action Analyst Rating Change
Apr-08-25 Initiated Leerink Partners Outperform
Mar-18-25 Initiated Wolfe Research Outperform
Sep-04-24 Initiated Wedbush Outperform
Jul-16-24 Initiated Evercore ISI Outperform
May-02-24 Initiated Robert W. Baird Outperform
Mar-01-24 Upgrade Wells Fargo Equal Weight → Overweight
Dec-20-23 Initiated BTIG Research Buy
Dec-11-23 Initiated Guggenheim Buy
Dec-11-23 Initiated Jefferies Buy
May-04-20 Initiated Piper Sandler Overweight
Mar-21-19 Initiated JP Morgan Overweight
Sep-04-18 Downgrade Wells Fargo Outperform → Market Perform
Apr-24-18 Initiated Evercore ISI Outperform
Mar-14-18 Reiterated Needham Buy
View All

Spyre Therapeutics Inc Stock (SYRE) Latest News

pulisher
May 30, 2025

Spyre Therapeutics to Participate in Upcoming June Investor Conferences - Eastern Progress

May 30, 2025
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May 30, 2025

Wall Street Analysts Predict a 244.05% Upside in Spyre Therapeutics (SYRE): Here's What You Should Know - sharewise

May 30, 2025
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May 30, 2025

Millennium Management LLC Acquires Shares of 167,804 Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 30, 2025
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May 30, 2025

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Grows Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 30, 2025
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May 28, 2025

Spyre Therapeutics to Participate in Upcoming June Investor Conf - GuruFocus

May 28, 2025
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May 28, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Given Average Recommendation of “Buy” by Analysts - Defense World

May 28, 2025
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May 28, 2025

Spyre Therapeutics IBD Pipeline Updates Coming at Major June Healthcare Conferences - Stock Titan

May 28, 2025
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May 28, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Purchased by Deutsche Bank AG - Defense World

May 28, 2025
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May 26, 2025

BNP Paribas Financial Markets Takes $437,000 Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 26, 2025
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May 19, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Acquired by Northern Trust Corp - Defense World

May 19, 2025
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May 14, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Acquired by The Manufacturers Life Insurance Company - Defense World

May 14, 2025
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May 13, 2025

How Much Upside is Left in Spyre Therapeutics (SYRE)? Wall Street Analysts Think 258.34% - Yahoo Finance

May 13, 2025
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May 10, 2025

First Trust Advisors LP Invests $548,000 in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 10, 2025
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May 10, 2025

Spyre Therapeutics (NASDAQ:SYRE) Shares Up 12.6% on Earnings Beat - Defense World

May 10, 2025
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May 09, 2025

Spyre Therapeutics: Q1 Earnings Snapshot - New Haven Register

May 09, 2025
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May 09, 2025

Spyre Therapeutics Reports Q1 2025 Financial Results - TipRanks

May 09, 2025
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May 08, 2025

Spyre (SYRE) Advances Clinical Trials with Strong Financial Backing | SYRE Stock News - GuruFocus

May 08, 2025
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May 08, 2025

Spyre Therapeutics Inc Reports Q1 2025 EPS of -$0.60, Beating Estimates, Amid $44.8 Million Net Loss - GuruFocus

May 08, 2025
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May 08, 2025

Spyre Therapeutics Reports First Quarter 2025 Financial Results and Provides Corporate Update - PR Newswire

May 08, 2025
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May 06, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Stock Position Boosted by Tower Research Capital LLC TRC - The AM Reporter

May 06, 2025
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May 06, 2025

MetLife Investment Management LLC Has $498,000 Stock Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - The AM Reporter

May 06, 2025
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May 06, 2025

Spyre Therapeutics (NASDAQ:SYRE) Given Outperform Rating at Wedbush - Defense World

May 06, 2025
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May 06, 2025

Brokerages Set Spyre Therapeutics, Inc. (NASDAQ:SYRE) PT at $49.57 - Defense World

May 06, 2025
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May 05, 2025

Spyre Presents Promising SPY001 IBD Data And Combination Therapy Results At DDW 2025 - Nasdaq

May 05, 2025
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May 05, 2025

Spyre Therapeutics (SYRE) Showcases Promising IBD Treatment Data at Upcoming Conference | SYRE Stock News - GuruFocus

May 05, 2025
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May 05, 2025

Spyre Therapeutics Announces Poster Presentations at Digestive Disease Week (DDW) 2025 Including Up to Eight months of Follow-up from an Ongoing Phase 1 Trial of SPY001 | SYRE Stock News - GuruFocus

May 05, 2025
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May 05, 2025

Spyre Therapeutics Announces Poster Presentations at Digestive Disease Week (DDW) 2025 Including Up to Eight months of Follow-up from an Ongoing Phase 1 Trial of SPY001 - PR Newswire

May 05, 2025
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May 04, 2025

Invesco Ltd. Sells 118,195 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 04, 2025
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May 03, 2025

Wells Fargo & Company MN Purchases 6,908 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

May 03, 2025
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May 02, 2025

Spyre Therapeutics Announces Grants of Inducement Awards | SYRE Stock News - GuruFocus

May 02, 2025
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May 02, 2025

Spyre Therapeutics Awards 64,400 Shares in Stock Options to Strategic New Employee Hires - Stock Titan

May 02, 2025
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May 01, 2025

Spyre Therapeutics (SYRE) to Release Earnings on Thursday - Defense World

May 01, 2025
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Apr 30, 2025

Barclays PLC Increases Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 30, 2025
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Apr 29, 2025

Analyzing Ratios: Arcutis Biotherapeutics Inc (ARQT)’s Financial Story Unveiled - DWinneX

Apr 29, 2025
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Apr 29, 2025

JPMorgan Chase & Co. Purchases 5,775 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 29, 2025
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Apr 24, 2025

Spyre Therapeutics Inc [SYRE] stock for 246,313 USD was sold by Albers Jeffrey W. - knoxdaily.com

Apr 24, 2025
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Apr 24, 2025

Are Smart Investors Making the Right Decision? Spyre Therapeutics Inc (SYRE) - Sete News

Apr 24, 2025
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Apr 23, 2025

Have you been able to find a good deal on Spyre Therapeutics Inc’s shares? - uspostnews.com

Apr 23, 2025
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Apr 22, 2025

Analyzing the Impact of Earnings Reports on Spyre Therapeutics Inc Inc. (SYRE) Price Performance - investchronicle.com

Apr 22, 2025
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Apr 19, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Purchased by Geode Capital Management LLC - The AM Reporter

Apr 19, 2025
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Apr 12, 2025

What is Leerink Partnrs’ Forecast for SYRE Q1 Earnings? - The AM Reporter

Apr 12, 2025
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Apr 11, 2025

Vanguard Group Inc. Buys 330,553 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 11, 2025
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Apr 11, 2025

Q1 Earnings Estimate for SYRE Issued By Leerink Partnrs - Defense World

Apr 11, 2025
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Apr 11, 2025

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Receives $50.33 Consensus Price Target from Brokerages - Defense World

Apr 11, 2025
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Apr 10, 2025

Corebridge Financial Inc. Has $401,000 Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 10, 2025
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Apr 10, 2025

Leerink Partnrs Upgrades Spyre Therapeutics (NASDAQ:SYRE) to “Strong-Buy” - Defense World

Apr 10, 2025
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Apr 09, 2025

KLP Kapitalforvaltning AS Invests $182,000 in Spyre Therapeutics, Inc. (NASDAQ:SYRE) - Defense World

Apr 09, 2025
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Apr 09, 2025

Spyre Therapeutics (NASDAQ:SYRE) Now Covered by Analysts at Leerink Partners - Defense World

Apr 09, 2025
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Apr 08, 2025

Leerink Partners Initiates Coverage of Spyre Therapeutics (SYRE) with Outperform Recommendation - Nasdaq

Apr 08, 2025
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Apr 08, 2025

Leerink Partners Initiates Spyre Therapeutics With Outperform Rating, $45 Price Target - marketscreener.com

Apr 08, 2025
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Apr 04, 2025

Biotech Spyre Therapeutics Awards 93,200 Stock Options in Key Talent Push - Stock Titan

Apr 04, 2025

Spyre Therapeutics Inc Stock (SYRE) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Spyre Therapeutics Inc Stock (SYRE) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Albers Jeffrey W.
Director
Oct 25 '24
Sale
36.43
300
10,929
34,060
$1.08
price up icon 1.89%
$30.14
price down icon 3.74%
$573.26
price down icon 1.32%
$304.56
price up icon 3.98%
$4.50
price down icon 3.02%
$490.28
price down icon 19.01%
Cap:     |  Volume (24h):