33.55
price up icon4.19%   1.35
pre-market  Pre-market:  33.79   0.24   +0.72%
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Spyre Therapeutics Inc stock is traded at $33.55, with a volume of 767.23K. It is up +4.19% in the last 24 hours and up +46.00% over the past month. Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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Previous Close:
$32.20
Open:
$32.18
24h Volume:
767.23K
Relative Volume:
0.88
Market Cap:
$2.60B
Revenue:
$688.00K
Net Income/Loss:
$-170.19M
P/E Ratio:
-11.00
EPS:
-3.0495
Net Cash Flow:
$-154.68M
1W Performance:
+12.77%
1M Performance:
+46.00%
6M Performance:
+103.09%
1Y Performance:
+19.86%
1-Day Range:
Value
$31.44
$34.54
1-Week Range:
Value
$28.16
$34.54
52-Week Range:
Value
$10.91
$34.54

Spyre Therapeutics Inc Stock (SYRE) Company Profile

Name
Name
Spyre Therapeutics Inc
Name
Phone
(617) 651-5940
Name
Address
221 CRESCENT STREET, WALTHAM
Name
Employee
95
Name
Twitter
Name
Next Earnings Date
2024-11-07
Name
Latest SEC Filings
Name
SYRE's Discussions on Twitter

Compare SYRE with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SYRE
Spyre Therapeutics Inc
33.55 2.50B 688.00K -170.19M -154.68M -3.0495
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
457.26 117.50B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
722.83 76.06B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
464.56 62.53B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ARGX
Argen X Se Adr
916.31 56.75B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
INSM
Insmed Inc
205.04 44.10B 447.02M -1.18B -906.14M -6.1812

Spyre Therapeutics Inc Stock (SYRE) Upgrades & Downgrades

Date Action Analyst Rating Change
Sep-26-25 Initiated Deutsche Bank Buy
Apr-08-25 Initiated Leerink Partners Outperform
Mar-18-25 Initiated Wolfe Research Outperform
Sep-04-24 Initiated Wedbush Outperform
Jul-16-24 Initiated Evercore ISI Outperform
May-02-24 Initiated Robert W. Baird Outperform
Mar-01-24 Upgrade Wells Fargo Equal Weight → Overweight
Dec-20-23 Initiated BTIG Research Buy
Dec-11-23 Initiated Guggenheim Buy
Dec-11-23 Initiated Jefferies Buy
May-04-20 Initiated Piper Sandler Overweight
Mar-21-19 Initiated JP Morgan Overweight
Sep-04-18 Downgrade Wells Fargo Outperform → Market Perform
Apr-24-18 Initiated Evercore ISI Outperform
Mar-14-18 Reiterated Needham Buy
View All

Spyre Therapeutics Inc Stock (SYRE) Latest News

pulisher
Dec 04, 2025

Spyre Therapeutics (NASDAQ:SYRE) CEO Cameron Turtle Sells 15,000 Shares - MarketBeat

Dec 04, 2025
pulisher
Dec 04, 2025

Will Spyre Therapeutics Inc. (3920) stock see insider accumulationEarnings Overview Report & Fast Momentum Stock Entry Tips - Newser

Dec 04, 2025
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Dec 04, 2025

Spyre Therapeutics (NASDAQ:SYRE) Trading Up 7.2%Still a Buy? - MarketBeat

Dec 04, 2025
pulisher
Dec 03, 2025

Spyre Therapeutics: A New Era Unfolds? - timothysykes.com

Dec 03, 2025
pulisher
Dec 03, 2025

A significant driver of top-line growth: Spyre Therapeutics Inc (SYRE) - Setenews

Dec 03, 2025
pulisher
Dec 03, 2025

Spyre Therapeutics stock reaches 52-week high at 30.56 USD By Investing.com - Investing.com Nigeria

Dec 03, 2025
pulisher
Dec 03, 2025

Spyre Therapeutics stock reaches 52-week high at 30.56 USD - Investing.com

Dec 03, 2025
pulisher
Dec 03, 2025

Is Spyre Therapeutics Inc. (3920) stock at risk of policy regulation2025 Valuation Update & Fast Exit and Entry Trade Guides - Newser

Dec 03, 2025
pulisher
Dec 03, 2025

Why Spyre Therapeutics Inc. stock is in analyst buy zone2025 AllTime Highs & Detailed Earnings Play Strategies - Newser

Dec 03, 2025
pulisher
Dec 02, 2025

Spyre Therapeutics (NASDAQ:SYRE) Sets New 12-Month High on Analyst Upgrade - MarketBeat

Dec 02, 2025
pulisher
Dec 02, 2025

Spyre Therapeutics (NASDAQ:SYRE) Upgraded by Jones Trading to Buy Rating - MarketBeat

Dec 02, 2025
pulisher
Dec 02, 2025

What is the fair value of Spyre Therapeutics Inc. stock nowRate Hike & Verified Momentum Stock Watchlist - Newser

Dec 02, 2025
pulisher
Dec 02, 2025

Spyre Therapeutics (NASDAQ:SYRE) Upgraded by Jones Trading to “Buy” Rating - Defense World

Dec 02, 2025
pulisher
Dec 02, 2025

Spyre Therapeutics (NASDAQ:SYRE) Sets New 52-Week High After Analyst Upgrade - Defense World

Dec 02, 2025
pulisher
Dec 02, 2025

Can Spyre Therapeutics Inc. stock deliver consistent earnings growthMarket Performance Summary & Risk Controlled Swing Alerts - Newser

Dec 02, 2025
pulisher
Dec 01, 2025

Jones Trading Upgrades Spyre Therapeutics (SYRE) - Nasdaq

Dec 01, 2025
pulisher
Dec 01, 2025

SYRE Stock Upgraded by Jones Trading; New Price Target Set at $6 - GuruFocus

Dec 01, 2025
pulisher
Dec 01, 2025

Spyre Therapeutics, Inc. $SYRE Shares Acquired by Franklin Resources Inc. - MarketBeat

Dec 01, 2025
pulisher
Dec 01, 2025

Spyre Therapeutics, Inc. $SYRE Shares Purchased by Intech Investment Management LLC - Defense World

Dec 01, 2025
pulisher
Dec 01, 2025

Spyre Therapeutics, Inc. $SYRE Shares Purchased by Geode Capital Management LLC - MarketBeat

Dec 01, 2025
pulisher
Dec 01, 2025

Spyre stock rating upgraded to Buy at Jones Trading on TL1A blockade potential - Investing.com Canada

Dec 01, 2025
pulisher
Nov 30, 2025

Nasdaq Composite Tracks Rising Biotech Momentum At Spyre Therapeutics - Kalkine Media

Nov 30, 2025
pulisher
Nov 27, 2025

What analysts say about Spyre Therapeutics Inc 3920 stockFundamental Stock Analysis & Big Returns Low Cost - earlytimes.in

Nov 27, 2025
pulisher
Nov 26, 2025

A Look at Spyre Therapeutics Inc (SYRE) Shares in the Recent Past Indicates Growth - Setenews

Nov 26, 2025
pulisher
Nov 25, 2025

Spyre Therapeutics stock hits 52-week high at 29.1 USD By Investing.com - Investing.com South Africa

Nov 25, 2025
pulisher
Nov 25, 2025

Spyre Therapeutics stock hits 52-week high at 29.1 USD - Investing.com India

Nov 25, 2025
pulisher
Nov 21, 2025

Why Spyre Therapeutics Inc. (3920) stock benefits from AI revolutionWeekly Market Outlook & Weekly Stock Performance Updates - newser.com

Nov 21, 2025
pulisher
Nov 21, 2025

Can Spyre Therapeutics Inc. stock deliver strong Q4 earningsMarket Movers & Fast Entry High Yield Tips - newser.com

Nov 21, 2025
pulisher
Nov 21, 2025

Is Spyre Therapeutics Inc. (3920) stock worth buying before Fed actionTrend Reversal & Daily Stock Momentum Reports - newser.com

Nov 21, 2025
pulisher
Nov 20, 2025

Top investors say Spyre Therapeutics Inc (SYRE) ticks everything they need - Setenews

Nov 20, 2025
pulisher
Nov 19, 2025

Earnings visualization tools for Spyre Therapeutics Inc. - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Will Spyre Therapeutics Inc. (3920) stock recover faster than industryJuly 2025 Patterns & Fast Entry and Exit Trade Plans - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Using data tools to time your Spyre Therapeutics Inc. exit2025 Top Gainers & Safe Entry Momentum Tips - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Why Spyre Therapeutics Inc. stock is seen as undervaluedTrend Reversal & Reliable Entry Point Trade Alerts - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Backtesting results for Spyre Therapeutics Inc. trading strategiesQuarterly Portfolio Review & Long-Term Safe Investment Plans - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Will Spyre Therapeutics Inc. (3920) stock announce special dividend2025 Earnings Impact & Accurate Intraday Trading Signals - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

Is a relief rally coming for Spyre Therapeutics Inc. holdersQuarterly Investment Review & Free Reliable Trade Execution Plans - newser.com

Nov 19, 2025
pulisher
Nov 19, 2025

What margin trends mean for Spyre Therapeutics Inc. stock2025 Geopolitical Influence & Verified Momentum Stock Watchlist - newser.com

Nov 19, 2025

Spyre Therapeutics Inc Stock (SYRE) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$39.16
price down icon 1.10%
$100.48
price down icon 1.00%
$32.03
price up icon 1.10%
$95.99
price down icon 0.77%
biotechnology ONC
$331.27
price down icon 1.95%
$205.04
price down icon 0.84%
Cap:     |  Volume (24h):