2.88
price down icon1.71%   -0.05
pre-market  Pre-market:  2.86   -0.02   -0.69%
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Spero Therapeutics Inc stock is traded at $2.88, with a volume of 1.01M. It is down -1.71% in the last 24 hours and up +313.61% over the past month. Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. Besides, it is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
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Previous Close:
$2.93
Open:
$2.97
24h Volume:
1.01M
Relative Volume:
0.26
Market Cap:
$156.55M
Revenue:
$76.19M
Net Income/Loss:
$-1.61M
P/E Ratio:
288.00
EPS:
0.01
Net Cash Flow:
$28.98M
1W Performance:
-0.69%
1M Performance:
+313.61%
6M Performance:
+207.20%
1Y Performance:
+116.54%
1-Day Range:
Value
$2.81
$2.97
1-Week Range:
Value
$2.81
$3.02
52-Week Range:
Value
$0.5052
$3.06

Spero Therapeutics Inc Stock (SPRO) Company Profile

Name
Name
Spero Therapeutics Inc
Name
Phone
857-242-1600
Name
Address
675 MASSACHUSETTS AVENUE, CAMBRIDGE, MA
Name
Employee
32
Name
Twitter
@spero_tx
Name
Next Earnings Date
2025-03-19
Name
Latest SEC Filings
Name
SPRO's Discussions on Twitter

Compare SPRO with other stocks

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Biotechnology icon
SPRO
Spero Therapeutics Inc
2.88 156.55M 76.19M -1.61M 28.98M 0.01
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VRTX
Vertex Pharmaceuticals Inc
450.27 115.95B 11.10B -988.90M -1.26B -3.92
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REGN
Regeneron Pharmaceuticals Inc
522.27 56.52B 14.09B 4.50B 2.96B 39.28
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ALNY
Alnylam Pharmaceuticals Inc
325.00 39.44B 2.35B -269.70M -75.39M -2.09
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ARGX
Argen X Se Adr
568.06 35.14B 2.58B 1.06B -1.28B 16.33
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ONC
Beone Medicines Ltd Adr
266.80 28.51B 3.81B -644.79M -669.77M -6.24

Spero Therapeutics Inc Stock (SPRO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-20-24 Downgrade Evercore ISI Outperform → In-line
Sep-23-22 Upgrade Evercore ISI In-line → Outperform
Oct-01-21 Downgrade Oppenheimer Outperform → Perform
Jan-22-21 Reiterated H.C. Wainwright Buy
Dec-16-20 Initiated Berenberg Buy
Sep-29-20 Initiated Evercore ISI Outperform
Nov-05-19 Reiterated H.C. Wainwright Buy
Sep-09-19 Initiated Janney Buy
Feb-09-18 Initiated Cantor Fitzgerald Overweight
Nov-27-17 Initiated BofA/Merrill Neutral
Nov-27-17 Initiated Oppenheimer Outperform
Nov-27-17 Initiated Stifel Buy
View All

Spero Therapeutics Inc Stock (SPRO) Latest News

pulisher
Jun 17, 2025

Complicated Urinary Tract Infection Pipeline Appears Robust With 12+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight - The Globe and Mail

Jun 17, 2025
pulisher
Jun 12, 2025

SPRO’s Stock Market Pendulum: Swinging Between Gains and Losses - investchronicle.com

Jun 12, 2025
pulisher
Jun 11, 2025

Spero TherapeuticsAdditional Upside Potential Following Positive Phase 3 Results (SPRO) - Seeking Alpha

Jun 11, 2025
pulisher
Jun 11, 2025

Squarepoint Ops LLC Buys Shares of 55,051 Spero Therapeutics, Inc. (NASDAQ:SPRO) - Defense World

Jun 11, 2025
pulisher
Jun 09, 2025

Spero Therapeutics COO Timothy Keutzer sells shares for $44,097 - MSN

Jun 09, 2025
pulisher
Jun 09, 2025

Jane Street Group LLC Takes Position in Spero Therapeutics, Inc. (NASDAQ:SPRO) - Defense World

Jun 09, 2025
pulisher
Jun 06, 2025

Spero Therapeutics Inc (SPRO) Is A Good Stock To Invest In - Stocksregister

Jun 06, 2025
pulisher
Jun 06, 2025

Spero Therapeutics, Inc. (NASDAQ:SPRO) Stake Boosted by Mackenzie Financial Corp - Defense World

Jun 06, 2025
pulisher
Jun 06, 2025

GSK, Spero Therapeutics Stop Antibiotic Trial For Complicated Urinary Tract Infections Early After Positive Results, Retail’s Thrilled - MSN

Jun 06, 2025
pulisher
Jun 04, 2025

Northern Trust Corp Sells 25,050 Shares of Spero Therapeutics, Inc. (NASDAQ:SPRO) - Defense World

Jun 04, 2025
pulisher
May 31, 2025

Why Spero Therapeutics, Inc. (SPRO) Surged Last Week - Insider Monkey

May 31, 2025
pulisher
May 31, 2025

Spero Therapeutics stock hits 52-week high at $2.53 By Investing.com - Investing.com South Africa

May 31, 2025
pulisher
May 30, 2025

Spero Therapeutics stock hits 52-week high at $2.53 - Investing.com India

May 30, 2025
pulisher
May 30, 2025

Spero Therapeutics Jumps as Oral Carbapenem Hits Phase 3 Milestone - MSN

May 30, 2025
pulisher
May 30, 2025

SPRO Stock Soars 245% on GSK-Partnered UTI Drug Meeting Study Goal - MSN

May 30, 2025
pulisher
May 29, 2025

Spero Therapeutics Stock (SPRO) Rockets 225% on Clinical Trial Data - The Globe and Mail

May 29, 2025
pulisher
May 29, 2025

Spero Therapeutics And 2 Other Promising Penny Stocks To Watch - Yahoo Finance

May 29, 2025
pulisher
May 29, 2025

Spero Therapeutics rockets on positive Phase III study for tebipenem HBr - The Pharma Letter

May 29, 2025
pulisher
May 28, 2025

Biotech Finds Mid-Week Success After Meeting Primary Endpoint - The Globe and Mail

May 28, 2025
pulisher
May 28, 2025

GSK’s Bet On Spero’s Oral cUTI Antibiotic Poised To Pay Off With New Phase III Data - insights.citeline.com

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics Stock Skyrockets on Strong Phase 3 Trial Results - MSN

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics (SPRO) Stock Explodes: Shares Skyrocket Over 200% in Stunning Midday Rally! - Daily Chhattisgarh News

May 28, 2025
pulisher
May 28, 2025

Why Is GSK Partner Spero Therapeutics Stock Skyrocketing On Wednesday? - Benzinga

May 28, 2025
pulisher
May 28, 2025

GSK, Spero stop UTI drug trial after early success - Reuters

May 28, 2025
pulisher
May 28, 2025

GSK, Spero Therapeutics Stop Antibiotic Trial For Complicated Urinary Tract Infections Early After Positive Results, Retail’s Thrilled By Stocktwits - Investing.com India

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics (SPRO) Soars 255% on Phase 3 Success - GuruFocus

May 28, 2025
pulisher
May 28, 2025

Pre-market Movers: SPRO, ASBP, IFRX, IMNN... - RTTNews

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics stock soars on positive phase 3 trial results By Investing.com - Investing.com Nigeria

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics stock soars on positive phase 3 trial results - Investing.com Australia

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics’ Phase 3 Trial Meets Primary Endpoint - TipRanks

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics and GSK Announce PIVOT-PO Phase 3 Study - GlobeNewswire

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics and GSK Announce PIVOT-PO Phase 3 Study for Tebipenem HBr Stopped Early for Efficacy Following Review by Independent Data Monitoring Committee | SPRO Stock News - GuruFocus

May 28, 2025
pulisher
May 28, 2025

Spero Therapeutics and GSK Announce PIVOT-PO Phase 3 Study for Tebipenem HBr Stopped Early for Efficacy Following Review by Independent Data Monitoring Committee - Yahoo Finance

May 28, 2025
pulisher
May 17, 2025

Analyzing Perrigo (NYSE:PRGO) & Spero Therapeutics (NASDAQ:SPRO) - Defense World

May 17, 2025
pulisher
May 15, 2025

Spero Therapeutics, Inc. (SPRO) Reports Q1 Loss, Misses Revenue Estimates - MSN

May 15, 2025
pulisher
May 14, 2025

Spero Therapeutics (SPRO) to Release Earnings on Wednesday - Defense World

May 14, 2025
pulisher
May 13, 2025

Spero Therapeutics Announces First Quarter 2025 Operating Results and Provides a Business Update - GlobeNewswire

May 13, 2025
pulisher
May 13, 2025

Spero Therapeutics Advances Phase 3 Trial With Strong Cash Position, Welcomes New CEO - Stock Titan

May 13, 2025
pulisher
May 13, 2025

SPERO THERAPEUTICS Earnings Results: $SPRO Reports Quarterly Earnings - Nasdaq

May 13, 2025
pulisher
May 13, 2025

Spero Therapeutics Inc (SPRO) Q1 2025: Everything You Need To Kn - GuruFocus

May 13, 2025
pulisher
May 07, 2025

Spero Therapeutics, Inc. (NASDAQ:SPRO) Shares Bought by JPMorgan Chase & Co. - Defense World

May 07, 2025
pulisher
May 05, 2025

Spero Therapeutics to Report First Quarter 2025 Financial Results and Provide Business Update on Tuesday, May 13, 2025 - The Manila Times

May 05, 2025
pulisher
May 05, 2025

Spero Therapeutics to Report First Quarter 2025 Financial - GlobeNewswire

May 05, 2025
pulisher
May 05, 2025

Spero Therapeutics to Report First Quarter 2025 Financial Results and Provide Business Update ... - Eagle-Tribune

May 05, 2025
pulisher
May 03, 2025

SPROSpero Therapeuti Latest Stock News & Market Updates - Stock Titan

May 03, 2025
pulisher
Apr 30, 2025

Renaissance Technologies LLC Increases Stake in Spero Therapeutics, Inc. (NASDAQ:SPRO) - Defense World

Apr 30, 2025

Spero Therapeutics Inc Stock (SPRO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Spero Therapeutics Inc Stock (SPRO) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Rajavelu Esther
CFO & CBO
Feb 05 '25
Sale
0.78
20,689
16,137
724,720
Shukla Sath
CEO & President
Feb 05 '25
Sale
0.78
155,333
121,160
1,736,883
Mahadevia Ankit
Director
Feb 05 '25
Sale
0.78
69,219
53,991
689,866
Rajavelu Esther
CFO & CBO
Nov 07 '24
Sale
1.31
23,351
30,590
396,515
Rajavelu Esther
CFO & CBO
Nov 08 '24
Sale
1.30
17,245
22,418
379,270
Mahadevia Ankit
Director
Aug 27 '24
Sale
1.35
5,912
7,981
759,085
Keutzer Timothy
Chief Operating Officer
Aug 27 '24
Sale
1.35
2,213
2,988
531,837
Shukla Sath
CEO & President
Aug 27 '24
Sale
1.35
2,757
3,722
1,140,809
Shukla Sath
CEO and President
Aug 05 '24
Sale
1.31
17,641
23,110
1,143,566
Shukla Sath
CEO and President
Aug 02 '24
Sale
1.32
14,800
19,536
1,161,207
$20.74
price up icon 0.29%
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price up icon 2.09%
$20.92
price up icon 2.60%
$105.90
price up icon 0.46%
$105.09
price up icon 2.02%
biotechnology ONC
$266.80
price up icon 3.61%
Cap:     |  Volume (24h):