34.75
price down icon3.47%   -1.25
pre-market  Pre-market:  34.35   -0.40   -1.15%
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Sionna Therapeutics Inc stock is traded at $34.75, with a volume of 375.11K. It is down -3.47% in the last 24 hours and down -13.60% over the past month. Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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Previous Close:
$36.00
Open:
$36.01
24h Volume:
375.11K
Relative Volume:
0.97
Market Cap:
$1.57B
Revenue:
-
Net Income/Loss:
$-85.57M
P/E Ratio:
-18.13
EPS:
-1.9166
Net Cash Flow:
$-72.14M
1W Performance:
+3.15%
1M Performance:
-13.60%
6M Performance:
-18.98%
1Y Performance:
+142.84%
1-Day Range:
Value
$34.42
$36.20
1-Week Range:
Value
$32.84
$37.82
52-Week Range:
Value
$13.51
$48.45

Sionna Therapeutics Inc Stock (SION) Company Profile

Name
Name
Sionna Therapeutics Inc
Name
Phone
617-819-2020
Name
Address
21 HICKORY DRIVE, SUITE 500, WALTHAM
Name
Employee
59
Name
Twitter
Name
Next Earnings Date
2026-05-11
Name
Latest SEC Filings
Name
SION's Discussions on Twitter

Compare SION vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SION icon
SION
Sionna Therapeutics Inc
34.75 1.63B 0 -85.57M -72.14M -1.9166
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
453.17 114.33B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
614.73 64.47B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
878.49 54.99B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
281.90 38.42B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
156.58 34.03B 742.00K -1.37B -1.07B -7.0731

Sionna Therapeutics Inc Stock (SION) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-24-26 Initiated Citizens Mkt Outperform
Dec-01-25 Downgrade RBC Capital Mkts Sector Perform → Underperform
Nov-19-25 Initiated BTIG Research Buy
Sep-03-25 Initiated RBC Capital Mkts Sector Perform
Sep-03-25 Initiated Raymond James Strong Buy
Mar-04-25 Initiated Guggenheim Buy
Mar-04-25 Initiated Stifel Buy
Mar-04-25 Initiated TD Cowen Buy
View All

Sionna Therapeutics Inc Stock (SION) Latest News

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Jun 15, 2026

SION Q1 2026 Earnings: Wider Loss Surprises as Clinical Progress ContinuesFinal Results - newsline.com

Jun 15, 2026
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Jun 13, 2026

Sionna Therapeutics - The Business Journals

Jun 13, 2026
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Jun 11, 2026

Assessing Sionna Therapeutics (SION) Valuation After A Mixed Period For Recent Share Price Returns - Yahoo Finance

Jun 11, 2026
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Jun 10, 2026

Transcript : Sionna Therapeutics, Inc. Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026, Jun-10-2026 10 - marketscreener.com

Jun 10, 2026
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Jun 10, 2026

Sionna Therapeutics (SION) Gains 1.81% as Biotech Sentiment ImprovesAdaptive Moving Average - newsline.com

Jun 10, 2026
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Jun 07, 2026

SION Q1 2026 Earnings: EPS Misses Estimates as Pre-Revenue Biotech Faces Investor SkepticismGrowth Acceleration Report - newsline.com

Jun 07, 2026
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Jun 03, 2026

Biotech Sionna Therapeutics at Jefferies and Goldman Sachs in June - Stock Titan

Jun 03, 2026
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May 30, 2026

Sionna Therapeutics director Peter Thompson sells $4,493 of shares - Investing.com India

May 30, 2026
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May 29, 2026

Sionna Therapeutics director Peter Thompson sells $4,493 of shares By Investing.com - Investing.com South Africa

May 29, 2026
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May 29, 2026

OrbiMed Advisors, director, sells $4,493 in Sionna Therapeutics stock - Investing.com

May 29, 2026
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May 29, 2026

OrbiMed Advisors, director, sells $4,493 in Sionna Therapeutics stock By Investing.com - Investing.com UK

May 29, 2026
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May 29, 2026

Form 144 | Sionna Therapeutics(SION.US) Insider Proposes to Sell 46.33 Million in Common Stocks - Moomoo

May 29, 2026
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May 28, 2026

Sionna Therapeutics (SION) Sees Slight Decline Amidst Key Support TestPre-Earnings Momentum - The Legal Advocate

May 28, 2026
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May 28, 2026

SIONSionna Therapeutics Inc. stock news, filings & ratings - Quantisnow

May 28, 2026
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May 27, 2026

Sionna Therapeutics (SION) Edges Higher as Biotech Sentiment Improves — Testing Key ResistanceAdvance Decline Volume - thelegaladvocate.com

May 27, 2026
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May 27, 2026

Sionna Therapeutics to Participate in Upcoming June 2026 Investor Conferences - markets.businessinsider.com

May 27, 2026
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May 26, 2026

SION Reiterates by Citizens -- Price Target Maintained at $63 - GuruFocus

May 26, 2026
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May 26, 2026

Stifel Nicolaus Sticks to Their Buy Rating for Sionna Therapeutics, Inc. (SION) - The Globe and Mail

May 26, 2026
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May 26, 2026

Stifel reiterates Buy on Sionna Therapeutics stock ahead of data - Investing.com

May 26, 2026
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May 26, 2026

Stifel reiterates Buy on Sionna Therapeutics stock ahead of data By Investing.com - Investing.com Canada

May 26, 2026
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May 26, 2026

Citizens reiterates Sionna Therapeutics stock rating on CF treatment potential By Investing.com - Investing.com Canada

May 26, 2026
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May 25, 2026

SION Q1 2026 Earnings: Clinical-Stage Biotech Misses Estimates with Wider Net LossEarnings Growth Forecast - newsline.com

May 25, 2026
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May 24, 2026

Number of shareholders of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

May 24, 2026
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May 24, 2026

A Quick Look at Today's Ratings for Sionna Therapeutics(SION.US), With a Forecast Between $50 to $63 - Moomoo

May 24, 2026
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May 21, 2026

Freedom Broker downgrades Sionna Therapeutics (SION) - MSN

May 21, 2026
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May 21, 2026

Sionna Therapeutics Cut to Hold From Buy by Freedom Broker - Moomoo

May 21, 2026
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May 20, 2026

SION: Phase II data for two NBD1 stabilizers in CF expected this summer, aiming for superior efficacy - TradingView

May 20, 2026
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May 20, 2026

Sionna Therapeutics Price Target Maintained With a $38.00/Share by Freedom Broker - Moomoo

May 20, 2026
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May 20, 2026

Sionna Therapeutics stock rating cut to Hold at Freedom Broker By Investing.com - Investing.com Canada

May 20, 2026
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May 19, 2026

SION Maintained by Stifel -- Price Target Raised to $55 - GuruFocus

May 19, 2026
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May 18, 2026

Sionna Therapeutics Price Target Raised to $55.00/Share From $44.00 by Stifel - Moomoo

May 18, 2026
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May 18, 2026

Wedbush Maintains Sionna Therapeutics(SION.US) With Buy Rating, Maintains Target Price $53 - Moomoo

May 18, 2026
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May 18, 2026

Stifel raises Sionna Therapeutics price target on NBD1 data confidence By Investing.com - Investing.com Canada

May 18, 2026
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May 18, 2026

Sionna Therapeutics (SION) Stock: Slides -0.80%, Support at $37.90 2026-05-18Strangle Setup - newsline.com

May 18, 2026
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May 17, 2026

User - FinancialContent

May 17, 2026
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May 16, 2026

Wedbush initiates coverage of Sionna Therapeutics (SION) with outperform recommendation - MSN

May 16, 2026
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May 16, 2026

Sionna Therapeutics, Inc. $SION Shares Purchased by Vanguard Group Inc. - MarketBeat

May 16, 2026
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May 15, 2026

Sionna Therapeutics Develops Next-Generation Cystic Fibrosis Modulators - HarianBasis.co

May 15, 2026
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May 14, 2026

RBC Capital Sticks to Its Sell Rating for Sionna Therapeutics, Inc. (SION) - The Globe and Mail

May 14, 2026
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May 14, 2026

Wedbush Initiates Coverage of Sionna Therapeutics (SION) - Insider Monkey

May 14, 2026
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May 13, 2026

Sionna Therapeutics to Participate in the 2026 RBC Capital Markets Global Healthcare Conference - The Manila Times

May 13, 2026
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May 13, 2026

Yazdi Reiterates Buy on Sionna, Keeps $58 Price Target Ahead of High-Impact 2026 SION-719 Readout - TipRanks

May 13, 2026
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May 13, 2026

LifeSci Capital Maintains Sionna Therapeutics(SION.US) With Buy Rating, Maintains Target Price $60 - Moomoo

May 13, 2026
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May 12, 2026

Sionna Therapeutics Q1 Net Loss Narrows - Moomoo

May 12, 2026
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May 12, 2026

Sionna Therapeutics (NASDAQ:SION) Stock Price Down 10.4% on Disappointing Earnings - MarketBeat

May 12, 2026
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May 12, 2026

Guggenheim reiterates Sionna Therapeutics stock rating at Buy By Investing.com - Investing.com Canada

May 12, 2026
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May 12, 2026

Raymond James reiterates Strong Buy on Sionna stock ahead of summer data - Investing.com

May 12, 2026

Sionna Therapeutics Inc Stock (SION) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Sionna Therapeutics Inc Stock (SION) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
ORBIMED ADVISORS LLC
Director
May 27 '26
Sale
44.49
101
4,493
2,671,721
$30.41
price up icon 1.27%
$55.40
price up icon 6.27%
$89.50
price down icon 1.43%
$54.21
price down icon 0.11%
ONC ONC
$263.92
price down icon 1.60%
$156.58
price down icon 2.17%
Cap:     |  Volume (24h):