44.93
price up icon4.20%   1.81
after-market After Hours: 44.71 -0.22 -0.49%
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Sionna Therapeutics Inc stock is traded at $44.93, with a volume of 622.93K. It is up +4.20% in the last 24 hours and up +27.03% over the past month. Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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Previous Close:
$43.12
Open:
$43.67
24h Volume:
622.93K
Relative Volume:
1.46
Market Cap:
$2.03B
Revenue:
-
Net Income/Loss:
$-85.57M
P/E Ratio:
-23.44
EPS:
-1.9166
Net Cash Flow:
$-72.14M
1W Performance:
+2.14%
1M Performance:
+27.03%
6M Performance:
+3.98%
1Y Performance:
+114.36%
1-Day Range:
Value
$43.00
$46.64
1-Week Range:
Value
$40.92
$46.64
52-Week Range:
Value
$16.38
$48.45

Sionna Therapeutics Inc Stock (SION) Company Profile

Name
Name
Sionna Therapeutics Inc
Name
Phone
617-819-2020
Name
Address
21 HICKORY DRIVE, SUITE 500, WALTHAM
Name
Employee
59
Name
Twitter
Name
Next Earnings Date
2026-08-10
Name
Latest SEC Filings
Name
SION's Discussions on Twitter

Compare SION vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
SION icon
SION
Sionna Therapeutics Inc
44.93 1.95B 0 -85.57M -72.14M -1.9166
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
522.25 134.41B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
676.23 68.13B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
919.94 57.01B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
321.59 41.79B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
190.46 40.39B 742.00K -1.37B -1.07B -7.0731

Sionna Therapeutics Inc Stock (SION) Upgrades & Downgrades

Date Action Analyst Rating Change
Feb-24-26 Initiated Citizens Mkt Outperform
Dec-01-25 Downgrade RBC Capital Mkts Sector Perform → Underperform
Nov-19-25 Initiated BTIG Research Buy
Sep-03-25 Initiated RBC Capital Mkts Sector Perform
Sep-03-25 Initiated Raymond James Strong Buy
Mar-04-25 Initiated Guggenheim Buy
Mar-04-25 Initiated Stifel Buy
Mar-04-25 Initiated TD Cowen Buy
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Sionna Therapeutics Inc Stock (SION) Latest News

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Jul 03, 2026

ETFs Investing in Sionna Therapeutics, Inc. Stocks - TradingView

Jul 03, 2026
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Jul 03, 2026

SIONSionna Therapeutics Inc Options - Finviz

Jul 03, 2026
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Jul 02, 2026

Sionna Therapeutics director Thompson sells $5.27m in stock - Investing.com

Jul 02, 2026
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Jul 02, 2026

Form 4 Sionna Therapeutics Inc For: 2 July By Investing.com - Investing.com Canada

Jul 02, 2026
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Jul 02, 2026

Sionna Therapeutics (SION) 10K Form and Latest SEC Filings 2026 - MarketBeat

Jul 02, 2026
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Jul 01, 2026

Enterprise value to EBITDA forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Enterprise value to EBIT forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Enterprise value to revenue forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Price to earnings forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jul 01, 2026

Price to sales forward of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

Jul 01, 2026
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Jun 30, 2026

Sionna Therapeutics: NBD1 Stabilization Could Redefine Cystic Fibrosis Treatment (SION) - Seeking Alpha

Jun 30, 2026
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Jun 29, 2026

Sionna Therapeutics, Inc.(NasdaqGM: SION) dropped from Russell 3000E Index - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Sionna Therapeutics, Inc.(NasdaqGM: SION) dropped from Russell Microcap Index - marketscreener.com

Jun 29, 2026
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Jun 25, 2026

Sionna Therapeutics, Inc. Actuals & Estimates (NASDAQ:SION) - TradingView

Jun 25, 2026
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Jun 25, 2026

SION Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 24, 2026

Analysts Offer Insights on Healthcare Companies: AbbVie (ABBV), Sionna Therapeutics, Inc. (SION) and Crescent Biopharma (CBIO) - The Globe and Mail

Jun 24, 2026
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Jun 23, 2026

Citizens reiterates Sionna Therapeutics stock rating ahead of summer data By Investing.com - Investing.com Nigeria

Jun 23, 2026
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Jun 22, 2026

Sionna Therapeutics: Buy Rating Reiterated on NBD1-Focused CF Strategy; $60 Price Target Maintained - TipRanks

Jun 22, 2026
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Jun 19, 2026

Sionna Stockholders Reelect Directors, Ratify Deloitte as Auditor - The Globe and Mail

Jun 19, 2026
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Jun 15, 2026

SION Q1 2026 Earnings: Wider Loss Surprises as Clinical Progress ContinuesFinal Results - newsline.com

Jun 15, 2026
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Jun 13, 2026

Sionna Therapeutics - The Business Journals

Jun 13, 2026
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Jun 11, 2026

Assessing Sionna Therapeutics (SION) Valuation After A Mixed Period For Recent Share Price Returns - Yahoo Finance

Jun 11, 2026
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Jun 10, 2026

Transcript : Sionna Therapeutics, Inc. Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026, Jun-10-2026 10 - marketscreener.com

Jun 10, 2026
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Jun 10, 2026

Sionna Therapeutics (SION) Gains 1.81% as Biotech Sentiment ImprovesBeta Neutral Pair - newsline.com

Jun 10, 2026
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Jun 07, 2026

SION Q1 2026 Earnings: EPS Misses Estimates as Pre-Revenue Biotech Faces Investor SkepticismGrowth Acceleration Report - newsline.com

Jun 07, 2026
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Jun 03, 2026

Sionna Therapeutics (SION) Jefferies Global Healthcare Conference 2026 Summary - Quartr

Jun 03, 2026
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Jun 03, 2026

Biotech Sionna Therapeutics at Jefferies and Goldman Sachs in June - Stock Titan

Jun 03, 2026
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May 30, 2026

Sionna Therapeutics director Peter Thompson sells $4,493 of shares - Investing.com India

May 30, 2026
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May 29, 2026

Sionna Therapeutics director Peter Thompson sells $4,493 of shares By Investing.com - Investing.com South Africa

May 29, 2026
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May 29, 2026

OrbiMed Advisors, director, sells $4,493 in Sionna Therapeutics stock - Investing.com

May 29, 2026
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May 29, 2026

OrbiMed Advisors, director, sells $4,493 in Sionna Therapeutics stock By Investing.com - Investing.com UK

May 29, 2026
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May 29, 2026

Form 144 | Sionna Therapeutics(SION.US) Insider Proposes to Sell 46.33 Million in Common Stocks - Moomoo

May 29, 2026
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May 28, 2026

Sionna Therapeutics (SION) Sees Slight Decline Amidst Key Support TestPre-Earnings Momentum - The Legal Advocate

May 28, 2026
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May 27, 2026

Sionna Therapeutics (SION) Edges Higher as Biotech Sentiment Improves — Testing Key ResistanceAdvance Decline Volume - thelegaladvocate.com

May 27, 2026
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May 27, 2026

Sionna Therapeutics to Participate in Upcoming June 2026 Investor Conferences - markets.businessinsider.com

May 27, 2026
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May 26, 2026

SION Reiterates by Citizens -- Price Target Maintained at $63 - GuruFocus

May 26, 2026
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May 26, 2026

Stifel Nicolaus Sticks to Their Buy Rating for Sionna Therapeutics, Inc. (SION) - The Globe and Mail

May 26, 2026
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May 26, 2026

Stifel reiterates Buy on Sionna Therapeutics stock ahead of data - Investing.com

May 26, 2026
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May 26, 2026

Stifel reiterates Buy on Sionna Therapeutics stock ahead of data By Investing.com - Investing.com Canada

May 26, 2026
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May 26, 2026

Citizens reiterates Sionna Therapeutics stock rating on CF treatment potential By Investing.com - Investing.com Canada

May 26, 2026
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May 25, 2026

SION Q1 2026 Earnings: Clinical-Stage Biotech Misses Estimates with Wider Net LossEarnings Growth Forecast - newsline.com

May 25, 2026
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May 24, 2026

Number of shareholders of Sionna Therapeutics, Inc. – NASDAQ:SION - TradingView

May 24, 2026
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May 24, 2026

A Quick Look at Today's Ratings for Sionna Therapeutics(SION.US), With a Forecast Between $50 to $63 - Moomoo

May 24, 2026
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May 21, 2026

Freedom Broker downgrades Sionna Therapeutics (SION) - MSN

May 21, 2026
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May 21, 2026

Sionna Therapeutics Cut to Hold From Buy by Freedom Broker - Moomoo

May 21, 2026
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May 20, 2026

SION: Phase II data for two NBD1 stabilizers in CF expected this summer, aiming for superior efficacy - TradingView

May 20, 2026
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May 20, 2026

Sionna Therapeutics Price Target Maintained With a $38.00/Share by Freedom Broker - Moomoo

May 20, 2026

Sionna Therapeutics Inc Stock (SION) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Sionna Therapeutics Inc Stock (SION) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Thompson Peter A.
Director
Jun 30 '26
Sale
45.50
115,844
5,270,902
2,555,877
ORBIMED ADVISORS LLC
Director
Jun 30 '26
Sale
45.50
115,844
5,270,902
2,555,877
Thompson Peter A.
Director
May 27 '26
Sale
44.49
101
4,493
2,671,721
ORBIMED ADVISORS LLC
Director
May 27 '26
Sale
44.49
101
4,493
2,671,721
$112.84
price up icon 1.17%
$57.80
price up icon 1.55%
$36.31
price up icon 2.60%
$79.77
price down icon 2.48%
ONC ONC
$308.96
price down icon 0.16%
$190.46
price up icon 0.25%
Cap:     |  Volume (24h):