27.98

0.36% 0.10

Septerna Inc (SEPN)

Overview News Price History Discussions Forecast

Septerna Inc stock is traded at $27.98, with a volume of 255.61K. It is up +0.36% in the last 24 hours and up +6.92% over the past month. Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.

Previous Close:

$27.88

Open:

$28.2

24h Volume:

255.61K

Relative Volume:

0.77

Market Cap:

$1.25B

Revenue:

Net Income/Loss:

P/E Ratio:

EPS:

Net Cash Flow:

1W Performance:

-2.24%

1M Performance:

+6.92%

6M Performance:

+145.44%

1Y Performance:

+31.05%

1-Day Range:

$27.72

$29.00

1-Week Range:

$27.50

$29.23

52-Week Range:

$4.17

$30.50

Septerna Inc Stock (SEPN) Company Profile

Name

Septerna Inc

Sector

Healthcare (1131)

Industry

Biotechnology (631)

Phone

650-338-3533

Address

250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO

Employee

Twitter

Next Earnings Date

Latest SEC Filings

SEPN's Discussions on Twitter

Compare SEPN with other stocks

Stocks	Price	Market Cap	Revenue	Net Income	Cash Flow	EPS
SEPN Septerna Inc	27.98	1.25B	0	0	0	0.00
VRTX Vertex Pharmaceuticals Inc	452.13	115.03B	11.74B	3.68B	3.34B	14.19
REGN Regeneron Pharmaceuticals Inc	776.31	81.12B	14.25B	4.58B	3.88B	41.77
ALNY Alnylam Pharmaceuticals Inc	400.17	52.54B	3.21B	43.57M	221.36M	0.2405
ARGX Argen X Se Adr	839.99	51.78B	3.06B	1.28B	447.35M	19.67
INSM Insmed Inc	177.12	37.12B	447.02M	-1.18B	-906.14M	-6.1812

Septerna Inc Stock (SEPN) Upgrades & Downgrades

Date	Action	Analyst	Rating Change
Dec-19-25	Initiated	Raymond James	Strong Buy
Dec-15-25	Initiated	Truist	Buy
Nov-14-25	Upgrade	Wells Fargo	Equal Weight → Overweight
Jun-23-25	Initiated	H.C. Wainwright	Buy
Feb-18-25	Downgrade	Wells Fargo	Overweight → Equal Weight
Nov-19-24	Initiated	Cantor Fitzgerald	Overweight
Nov-19-24	Initiated	JP Morgan	Overweight
Nov-19-24	Initiated	TD Cowen	Buy
Nov-19-24	Initiated	Wells Fargo	Overweight

View All

Septerna Inc Stock (SEPN) Latest News

Dec 29, 2025

What analysts say about Septerna Inc stockDividend Yield Trends & AI-Based Predictions Available Free - earlytimes.in

Dec 29, 2025

Dec 23, 2025

Jones Trading initiates coverage of Septerna (SEPN) with buy recommendation - MSN

Dec 23, 2025

Jones Trading Initiates Coverage of Septerna (SEPN) with Buy Recommendation - Nasdaq

Dec 23, 2025

Septerna stock initiated with Buy rating at Jones Trading on GPCR pipeline By Investing.com - Investing.com South Africa

Dec 23, 2025

Septerna stock initiated with Buy rating at Jones Trading on GPCR pipeline - Investing.com Nigeria

Dec 23, 2025

Septerna (NASDAQ:SEPN) Coverage Initiated at Jones Trading - MarketBeat

Dec 23, 2025

Dec 22, 2025

Septerna (SEPN): Valuation Check After Raymond James Buy Rating and S&P Pharma Index Inclusion - Sahm

Dec 22, 2025

Dec 21, 2025

Septerna, Inc.(NasdaqGM: SEPN) added to S&P Pharmaceuticals Select Industry Index - marketscreener.com

Dec 21, 2025

Septerna, Inc.(NasdaqGM: SEPN) added to NASDAQ Biotechnology Index - marketscreener.com

Dec 21, 2025

Septerna’s SEP-631 Study: A Potential Game-Changer in Pharmaceutical Research - MSN

Dec 21, 2025

Is New Coverage of Septerna (SEPN) Quietly Reframing Its GPCR Platform’s Risk‑Reward Profile? - simplywall.st

Dec 21, 2025

Septerna (NASDAQ:SEPN) Coverage Initiated at Raymond James Financial - Defense World

Dec 21, 2025

Dec 20, 2025

Septerna (NASDAQ:SEPN) Raised to "Strong-Buy" at Raymond James Financial - MarketBeat

Dec 20, 2025

Wall Street Zen Upgrades Septerna (NASDAQ:SEPN) to "Strong-Buy" - MarketBeat

Dec 20, 2025

Wall Street Zen Upgrades Septerna (NASDAQ:SEPN) to “Strong-Buy” - Defense World

Dec 20, 2025

Why Septerna Inc. stock could be next big winner2025 AllTime Highs & Risk Controlled Stock Pick Alerts - Улправда

Dec 20, 2025

Dec 19, 2025

Septerna Inc stock hits all-time high at 29.79 USD By Investing.com - Investing.com Nigeria

Dec 19, 2025

Septerna (NASDAQ:SEPN) Reaches New 12-Month HighShould You Buy? - MarketBeat

Dec 19, 2025

Septerna Inc stock hits all-time high at 29.79 USD - Investing.com

Dec 19, 2025

Raymond James Initiates Coverage of Septerna (SEPN) with Strong Buy Recommendation - Nasdaq

Dec 19, 2025

Raymond James initiates Septerna stock with Strong Buy rating, $38 target - Investing.com Australia

Dec 19, 2025

Raymond James Initiates Coverage on Septerna With Strong Buy Rating, $38 Price Target - marketscreener.com

Dec 19, 2025

Raymond James initiates Septerna stock with Strong Buy rating, $38 target By Investing.com - Investing.com India

Dec 19, 2025

Why Septerna Inc. stock is a must watch in 20252025 Sector Review & Risk Managed Investment Strategies - DonanımHaber

Dec 19, 2025

Dec 18, 2025

How institutional buying supports Septerna Inc. stockWeekly Earnings Recap & Daily Price Action Insights - Улправда

Dec 18, 2025

How Septerna Inc. stock benefits from tech adoptionInsider Selling & Long-Term Investment Growth Plans - Улправда

Dec 18, 2025

Septerna (NASDAQ:SEPN) Earns Buy Rating from Analysts at Truist Financial - Defense World

Dec 18, 2025

Septerna, Inc. (NASDAQ:SEPN) Receives $29.25 Average Target Price from Brokerages - Defense World

Dec 18, 2025

Dec 17, 2025

Septerna (NASDAQ:SEPN) Coverage Initiated at Truist Financial - MarketBeat

Dec 17, 2025

Septerna to Present at 44th Annual J.P. Morgan Healthcare Conference - The Manila Times

Dec 17, 2025

PRN_FinancialWrapper | PR NewswireSepterna to Present at 44th Annual J.P. Morgan Healthcare Conference - FinancialContent

Dec 17, 2025

Dec 15, 2025

Septerna, Inc. (NASDAQ:SEPN) Receives Consensus Recommendation of "Moderate Buy" from Brokerages - MarketBeat

Dec 15, 2025

Truist Securities initiates Septerna stock with Buy rating on novel drug pipeline By Investing.com - Investing.com South Africa

Dec 15, 2025

Truist Securities initiates Septerna stock with Buy rating on novel drug pipeline - Investing.com India

Dec 15, 2025

Truist Initiates Septerna at Buy With $34 Price Target - marketscreener.com

Dec 15, 2025

Dec 07, 2025

Strength Seen in Septerna, Inc. (SEPN): Can Its 7.0% Jump Turn into More Strength? - MSN

Dec 07, 2025

Dec 04, 2025

Will Septerna Inc. stock continue dividend increasesJuly 2025 Fed Impact & Smart Money Movement Tracker - Newser

Dec 04, 2025

Dec 03, 2025