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35.17
2.39%
-0.86
Pre-market:
36.21
1.04
+2.96%
Septerna Inc stock is traded at $35.17, with a volume of 282.91K.
It is down -2.39% in the last 24 hours and up +30.50% over the past month.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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Previous Close:
$36.03
Open:
$35.93
24h Volume:
282.91K
Relative Volume:
0.90
Market Cap:
$1.59B
Revenue:
$45.95M
Net Income/Loss:
$-48.88M
P/E Ratio:
-31.60
EPS:
-1.1129
Net Cash Flow:
$109.67M
1W Performance:
+13.42%
1M Performance:
+30.50%
6M Performance:
+34.08%
1Y Performance:
+233.68%
1-Day Range:
$35.06
$36.62
1-Week Range:
$30.41
$37.01
52-Week Range:
$9.8515
$37.01
Septerna Inc Stock (SEPN) Company Profile
Name
Septerna Inc
Sector
Industry
Phone
650-338-3533
Address
250 EAST GRAND AVENUE, SUITE 65, SOUTH SAN FRANCISCO
Compare SEPN vs VRTX, REGN, ARGX, ALNY, RVMD
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
SEPN
Septerna Inc
|
35.17 | 1.62B | 45.95M | -48.88M | 109.67M | -1.1129 |
VRTX
Vertex Pharmaceuticals Inc
|
453.17 | 114.33B | 12.34B | 4.34B | 3.71B | 16.87 |
REGN
Regeneron Pharmaceuticals Inc
|
614.73 | 64.47B | 14.92B | 4.42B | 3.79B | 41.04 |
ARGX
Argen X Se Adr
|
878.49 | 54.99B | 4.16B | 1.29B | 734.26M | 19.58 |
ALNY
Alnylam Pharmaceuticals Inc
|
281.90 | 38.42B | 4.29B | 577.22M | 641.34M | 4.2086 |
RVMD
Revolution Medicines Inc
|
156.58 | 34.03B | 742.00K | -1.37B | -1.07B | -7.0731 |
Septerna Inc Stock (SEPN) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Dec-19-25 | Initiated | Raymond James | Strong Buy |
| Dec-15-25 | Initiated | Truist | Buy |
| Nov-14-25 | Upgrade | Wells Fargo | Equal Weight → Overweight |
| Jun-23-25 | Initiated | H.C. Wainwright | Buy |
| Feb-18-25 | Downgrade | Wells Fargo | Overweight → Equal Weight |
| Nov-19-24 | Initiated | Cantor Fitzgerald | Overweight |
| Nov-19-24 | Initiated | JP Morgan | Overweight |
| Nov-19-24 | Initiated | TD Cowen | Buy |
| Nov-19-24 | Initiated | Wells Fargo | Overweight |
View All
Septerna Inc Stock (SEPN) Latest News
Septerna Inc. (SEPN) Jumps 5.6% as Shares Test Key Resistance LevelVolatility Term Structure - newsline.com
SEPN Q1 2026 Earnings: Narrower Loss Beats Expectations, Shares RiseProfit Margin Analysis - newsline.com
SEPN: 8,428 shares proposed sale; Samira Shaikhly 10b5-1 sales listed - Stock Titan
Septerna (SEPN) 10K Form and Latest SEC Filings 2026 - MarketBeat
Guggenheim Initiates Septerna at Buy With $52 Price Target - Moomoo
Septerna Inc stock reaches all-time high at 32.76 USD - Investing.com
Did SEP-479’s Endocrine Society Spotlight Just Shift Septerna’s (SEPN) Hypoparathyroidism Investment Narrative? - simplywall.st
Septerna to Present Preclinical Characterization of SEP-479, an Oral PTH1R Agonist for Hypoparathyroidism, at 2026 ENDO Annual Meeting - Lelezard
Raymond James raises Septerna stock price target on pipeline potential - Investing.com UK
Experimental oral hypoparathyroidism drug SEP-479 gets ENDO 2026 stage - Stock Titan
Raymond James raises Septerna stock price target on pipeline potential By Investing.com - Investing.com Australia
Raymond James Maintains Septerna(SEPN.US) With Buy Rating, Raises Target Price to $53 - Moomoo
SEPN Financials: Revenue Breakdown, Margins & Competitor Comparison - Intellectia AI
Septerna’s chief people officer sells $171,682 in stock By Investing.com - Investing.com Australia
Septerna’s chief people officer sells $171,682 in stock - Investing.com
Septerna (SEPN) CPO sells 5,935 shares under Rule 10b5-1 plan - Stock Titan
SEPN Q1 2026 Earnings: Smaller-Than-Expected Loss Reflects Operational DisciplineNegative Surprise Momentum - newsline.com
Septerna Inc. (SEPN) Slips 2.74% as Stock Tests Key Support LevelsContinuation Pattern Picks - The Legal Advocate
Septerna chief people officer Samira Shaikhly sells $354,656 common stock By Investing.com - Investing.com South Africa
Septerna Inc. (SEPN) Faces Pressure: Key Support Levels in Focus Amid 3.77% DeclineAndrews Pitchfork - The Legal Advocate
SEPN Q1 2026 Earnings: EPS Beat Drives Optimism Amid Pre-Revenue PhaseProfit Growth Outlook - newsline.com
Septerna (SEPN) Chief People Officer exercises options and sells 11,798 shares - Stock Titan
Septerna chief people officer Samira Shaikhly sells $354,656 common stock - Investing.com
Septerna Inc. (SEPN) Surges 8% as Bullish Momentum BuildsSentiment Shift - The Legal Advocate
SEPN (NASDAQ: SEPN) option exercise sale of 11,798 shares on 05/26/2026 - Stock Titan
3 Unknown Small-Cap Stocks with ‘Strong Buy’ Ratings and Up to 70% Upside in 2026 - TipRanks
Septerna Inc. Q1 2026 Earnings: Narrower‑Than‑Expected Loss Boosts Investor SentimentGuidance Upgrade Report - The Legal Advocate
SEPN Q1 2026 Earnings: Smaller-Than-Expected Loss Amidst Pipeline ProgressEarnings Revision Downgrade - Newser
SEPN Q1 2026 Earnings: Narrower-Than-Expected Loss Highlights Cost DisciplineExpert Momentum Signals - Newser
Septerna Inc. (SEPN) Q1 2026 Earnings: Smaller-than-Expected Loss Drives Positive Market ResponseCommunity Pattern Alerts - Newser
Septerna Inc. (SEPN) Q1 2026 Earnings: Narrower-Than-Expected Loss Highlights Cost DisciplineROA Comparison - Newser
New Forecasts: Here's What Analysts Think The Future Holds For Septerna, Inc. (NASDAQ:SEPN) - Sahm
Septerna, Inc. (SEPN) Competitors - Meyka
Septerna (SEPN) Q1 2026 Crushes Forecasts — EPS $-0.19 vs $-0.42Free Stock Community - Newser
Why Septerna (SEPN) Is Up 11.6% After Q1 Revenue Surge And Narrowed Losses - simplywall.st
Party Time: Brokers Just Made Major Increases To Their Septerna, Inc. (NASDAQ:SEPN) Earnings Forecasts - Yahoo Finance
Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported And Analysts Are Boosting Their Estimates - Yahoo Finance
Q2 Earnings Forecast for Septerna Issued By HC Wainwright - MarketBeat
Septerna Inc Stock (SEPN) Financials Data
Revenue
Net Income
Cash Flow
EPS
Septerna Inc Stock (SEPN) Insider Trading
| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total |
|---|---|---|---|---|---|---|---|
| Shaikhly Samira | Chief People Officer |
Jun 01 '26 |
Option Exercise |
1.87 |
5,935 |
11,111 |
6,728 |
| Shaikhly Samira | Chief People Officer |
Jun 01 '26 |
Sale |
28.93 |
5,935 |
171,682 |
793 |
| Shaikhly Samira | Chief People Officer |
May 26 '26 |
Option Exercise |
6.81 |
11,798 |
80,344 |
12,591 |
| Shaikhly Samira | Chief People Officer |
May 26 '26 |
Sale |
30.06 |
11,798 |
354,656 |
793 |
1.27%
1.43%
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