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Prelude Therapeutics Inc stock is traded at $2.678, with a volume of 474.71K. It is down -3.67% in the last 24 hours and up +32.57% over the past month. Prelude Therapeutics Incorp is a clinical stage precision oncology company focused on discovering and developing small molecule therapies optimized to target the key driver mechanisms in cancers with high unmet needs. The company's pipeline includes four candidates currently in clinical development: PRT1419, a potent, selective inhibitor of MCL1; PRT2527, a potent and selective CDK9 inhibitor, PRT3645, a next-generation CDK4/6 inhibitor, and PRT3789 a first-in-class SMARCA2/BRM protein degrader.
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Previous Close:
$2.78
Open:
$2.79
24h Volume:
474.71K
Relative Volume:
1.08
Market Cap:
$168.79M
Revenue:
-
Net Income/Loss:
$-131.52M
P/E Ratio:
-1.5045
EPS:
-1.78
Net Cash Flow:
$-107.56M
1W Performance:
+20.09%
1M Performance:
+32.57%
6M Performance:
+115.97%
1Y Performance:
+207.50%
1-Day Range:
Value
$2.60
$3.04
1-Week Range:
Value
$2.06
$3.04
52-Week Range:
Value
$0.6101
$4.22

Prelude Therapeutics Inc Stock (PRLD) Company Profile

Name
Name
Prelude Therapeutics Inc
Name
Phone
(302) 467-1280
Name
Address
175 INNOVATION BOULEVARD, WILMINGTON
Name
Employee
131
Name
Twitter
Name
Next Earnings Date
2024-10-30
Name
Latest SEC Filings
Name
PRLD's Discussions on Twitter

Compare PRLD vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
PRLD
Prelude Therapeutics Inc
2.685 174.77M 0 -131.52M -107.56M -1.78
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
485.80 121.15B 12.07B 3.95B 3.19B 15.33
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
785.38 82.43B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
829.66 52.25B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
330.60 44.59B 3.71B 313.75M 465.38M 2.2571
Biotechnology icon
ONC
Beone Medicines Ltd Adr
366.48 40.07B 4.98B 69.60M 525.67M 0.5198

Prelude Therapeutics Inc Stock (PRLD) Upgrades & Downgrades

Date Action Analyst Rating Change
Sep-19-24 Upgrade H.C. Wainwright Neutral → Buy
Jun-20-24 Downgrade Barclays Equal Weight → Underweight
Mar-13-24 Initiated JMP Securities Mkt Outperform
Feb-20-24 Downgrade H.C. Wainwright Buy → Neutral
Dec-19-23 Downgrade Morgan Stanley Equal-Weight → Underweight
Nov-21-22 Downgrade BofA Securities Neutral → Underperform
Sep-09-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Jul-29-22 Initiated Jefferies Buy
Mar-15-22 Downgrade BofA Securities Buy → Neutral
Feb-28-22 Downgrade Barclays Overweight → Equal Weight
Oct-08-21 Upgrade Morgan Stanley Equal-Weight → Overweight
Jul-27-21 Upgrade BofA Securities Neutral → Buy
Apr-26-21 Initiated H.C. Wainwright Buy
Mar-09-21 Initiated Barclays Overweight
Nov-20-20 Downgrade BofA Securities Buy → Neutral
Oct-20-20 Initiated BofA Securities Buy
Oct-20-20 Initiated Goldman Neutral
Oct-20-20 Initiated Morgan Stanley Equal-Weight
View All

Prelude Therapeutics Inc Stock (PRLD) Latest News

pulisher
Feb 22, 2026

Quarterly Risk: Does Prelude Therapeutics Incorporated have consistent dividend growthJuly 2025 Earnings & Safe Capital Allocation Plans - baoquankhu1.vn

Feb 22, 2026
pulisher
Feb 17, 2026

Guidance Update: Is Prelude Therapeutics Incorporated stock trending bullishTreasury Yields & Technical Entry and Exit Alerts - baoquankhu1.vn

Feb 17, 2026
pulisher
Feb 17, 2026

Prelude Therapeutics Incorporated (NASDAQ:PRLD) Short Interest Update - MarketBeat

Feb 17, 2026
pulisher
Feb 13, 2026

How Prelude Therapeutics’ deal with Incyte changed its course - Delaware Business Times

Feb 13, 2026
pulisher
Feb 11, 2026

What’s the beta of Prelude Therapeutics Incorporated stock2025 AllTime Highs & AI Powered Market Entry Strategies - mfd.ru

Feb 11, 2026
pulisher
Feb 11, 2026

Aug Chart Watch: Is NeuroSense Therapeutics Ltd Equity Warrant benefiting from interest rate changesGlobal Markets & Real-Time Stock Price Movement Reports - baoquankhu1.vn

Feb 11, 2026
pulisher
Feb 11, 2026

Is Prelude Therapeutics Incorporated a cyclical or defensive stock2025 Sector Review & High Accuracy Swing Entry Alerts - mfd.ru

Feb 11, 2026
pulisher
Feb 11, 2026

Is Prelude Therapeutics Incorporated in a long term uptrendJuly 2025 Market Mood & Technical Buy Zone Confirmation - mfd.ru

Feb 11, 2026
pulisher
Feb 10, 2026

Prelude Therapeutics (NASDAQ:PRLD) Trading Down 0.9%Should You Sell? - MarketBeat

Feb 10, 2026
pulisher
Feb 09, 2026

Is Prelude Therapeutics Incorporated stock trending bullishWeekly Profit Recap & High Accuracy Buy Signal Tips - baoquankhu1.vn

Feb 09, 2026
pulisher
Feb 08, 2026

Prelude Therapeutics Secures FDA Clearance for Key Drug Candidate - AD HOC NEWS

Feb 08, 2026
pulisher
Feb 06, 2026

Weekly Buzz: ATYR To Meet With FDA, SGMO Aces Fabry Study, AQST's Anaphylm Gets Rejected - RTTNews

Feb 06, 2026
pulisher
Feb 06, 2026

Take Profit: Does Prelude Therapeutics Incorporated have a sustainable dividendTrade Analysis Summary & Daily Entry Point Trade Alerts - baoquankhu1.vn

Feb 06, 2026
pulisher
Feb 05, 2026

Why Did PRLD Stock Surge 13% Today? - Stocktwits

Feb 05, 2026
pulisher
Feb 05, 2026

Aug Wrap: Is ETRACS 2xMonthly Pay Leveraged Index ETN benefiting from interest rate changes2025 Market WrapUp & Weekly Stock Breakout Alerts - baoquankhu1.vn

Feb 05, 2026
pulisher
Feb 05, 2026

The $71 Billion Cancer Shift: Why The FDA Is Speeding Up - GlobeNewswire

Feb 05, 2026
pulisher
Feb 04, 2026

Why did PRLD stock surge 13% today? - MSN

Feb 04, 2026
pulisher
Feb 04, 2026

Prelude’s JAK2 V617F inhibitor PRT-12396 gains IND clearance - BioWorld MedTech

Feb 04, 2026
pulisher
Feb 04, 2026

Prelude Therapeutics stock gets reiterated Market Outperform rating at Citizens - Investing.com Canada

Feb 04, 2026
pulisher
Feb 03, 2026

FDA clears Prelude Therapeutics’ IND for JAK2 inhibitor in blood disorders - Investing.com Canada

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics (PRLD) Advances Blood Cancer Drug Trial wit - GuruFocus

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics Incorporated Receives FDA Clearance of Investigational New Drug Application for PRT12396 - marketscreener.com

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics stock surges after FDA clears IND for cancer drug By Investing.com - Investing.com South Africa

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude climbs as FDA clears study for Incyte-partnered cancer candidate - Seeking Alpha

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics stock surges after FDA clears IND for cancer drug - Investing.com India

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics receives FDA clearance of investigational new drug application (IND) for PRT12396, a mutant-selective JAK2V617F inhibitor - marketscreener.com

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics (PRLD) Gains FDA Approval for Phase 1 Study of PRT12396 - GuruFocus

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics Wins FDA IND Clearance for PRT12396 - TipRanks

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics Inc FDA Clearance for PRT12396 Phase 1 Study - TradingView

Feb 03, 2026
pulisher
Feb 03, 2026

Prelude Therapeutics Receives FDA Clearance of Investigational New Drug Application (IND) for PRT12396, a Mutant-selective JAK2V617F Inhibitor - ChartMill

Feb 03, 2026
pulisher
Jan 28, 2026

Prelude Therapeutics’ PRT2527 Trial Completion: What Investors Should Watch in Hematologic Oncology - TipRanks

Jan 28, 2026
pulisher
Jan 26, 2026

Hedge Fund Bets: Will Prelude Therapeutics Incorporated announce a stock splitJuly 2025 Macro Moves & Precise Swing Trade Alerts - baoquankhu1.vn

Jan 26, 2026
pulisher
Jan 26, 2026

Retail investors in Prelude Therapeutics Incorporated (NASDAQ:PRLD) are its biggest bettors, and their bets paid off as stock gained 12% last week - Yahoo Finance

Jan 26, 2026
pulisher
Jan 21, 2026

Aug Highlights: Does MAMO outperform in volatile markets2025 Support & Resistance & Free Weekly Watchlist of Top Performers - baoquankhu1.vn

Jan 21, 2026
pulisher
Jan 18, 2026

Prelude Therapeutics (NASDAQ:PRLD) Rating Lowered to Hold at Wall Street Zen - MarketBeat

Jan 18, 2026
pulisher
Jan 16, 2026

Aug Reactions: Can Prelude Therapeutics Incorporated outperform under higher oil pricesQuarterly Portfolio Summary & High Accuracy Swing Trade Signals - baoquankhu1.vn

Jan 16, 2026
pulisher
Jan 12, 2026

Market Review: Is Prelude Therapeutics Incorporated a cyclical or defensive stockMarket Volume Report & Community Verified Trade Signals - baoquankhu1.vn

Jan 12, 2026
pulisher
Jan 10, 2026

How Prelude Therapeutics Incorporated stock compares to industry benchmarksPortfolio Risk Report & Free Community Consensus Stock Picks - ulpravda.ru

Jan 10, 2026
pulisher
Jan 10, 2026

How Prelude Therapeutics Incorporated stock responds to policy changesMarket Activity Recap & Fast Entry High Yield Stock Tips - ulpravda.ru

Jan 10, 2026
pulisher
Jan 10, 2026

Prelude Therapeutics (NASDAQ:PRLD) Stock Rating Upgraded by Wall Street Zen - MarketBeat

Jan 10, 2026
pulisher
Jan 09, 2026

Prelude Therapeutics Inc Announces New Clinical Developments - TradingView — Track All Markets

Jan 09, 2026
pulisher
Jan 08, 2026

Aug Sentiment: How Prelude Therapeutics Incorporated stock responds to policy changesWeekly Investment Summary & Real-Time Market Sentiment Alerts - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Will Prelude Therapeutics Incorporated stock reach all time highs in 2025Portfolio Update Report & Expert Verified Movement Alerts - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Will Prelude Therapeutics Incorporated stock benefit from AI adoptionJuly 2025 Rallies & Free Real-Time Market Sentiment Alerts - Улправда

Jan 08, 2026
pulisher
Jan 08, 2026

Quarterly Trades: Is Prelude Therapeutics Incorporated stock positioned well for digital economyStop Loss & Free Daily Entry Point Trade Alerts - ulpravda.ru

Jan 08, 2026
pulisher
Jan 06, 2026

Prelude Therapeutics Reshapes Pipeline With Incyte Deal and Strategic Refocus - MSN

Jan 06, 2026
pulisher
Dec 31, 2025

Prelude Therapeutics Incorporated (NASDAQ:PRLD) Short Interest Up 28.5% in December - MarketBeat

Dec 31, 2025
pulisher
Dec 30, 2025

Bullish Prelude Therapeutics Insiders Rewarded As Their Investment Rises To US$2.75m - Sahm

Dec 30, 2025
pulisher
Dec 29, 2025

Prelude Therapeutics Incorporated's (NASDAQ:PRLD) Path To Profitability - Yahoo Finance

Dec 29, 2025
pulisher
Dec 25, 2025

Prelude Therapeutics (NASDAQ:PRLD) Stock Price Up 2.1%What's Next? - MarketBeat

Dec 25, 2025

Prelude Therapeutics Inc Stock (PRLD) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Prelude Therapeutics Inc Stock (PRLD) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Vaddi Krishna
CEO
Mar 25 '25
Buy
0.69
675,000
467,438
1,999,296
Vaddi Krishna
CEO
Mar 21 '25
Buy
0.73
15,000
10,959
1,324,296
Vaddi Krishna
CEO
Mar 20 '25
Buy
0.73
5,416
3,950
1,309,296
Vaddi Krishna
CEO
Mar 14 '25
Buy
0.75
29,999
22,631
1,294,774
Vaddi Krishna
CEO
Mar 17 '25
Buy
0.75
9,106
6,829
1,303,880
Vaddi Krishna
CEO
Mar 13 '25
Buy
0.72
50,000
35,820
1,264,775
Vaddi Krishna
CEO
Mar 12 '25
Buy
0.71
47,500
33,744
1,214,775
$101.66
price down icon 0.09%
$50.51
price up icon 1.10%
$100.35
price down icon 0.96%
$109.15
price down icon 1.00%
$160.30
price down icon 2.59%
biotechnology ONC
$366.08
price up icon 0.93%
Cap:     |  Volume (24h):