4.06
price down icon0.98%   -0.04
after-market After Hours: 4.06
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Orchestra Biomed Holdings Inc stock is traded at $4.06, with a volume of 198.27K. It is down -0.98% in the last 24 hours and down -3.56% over the past month. Orchestra BioMed Holdings Inc is a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships with medical device companies. The company's flagship product candidates are Atrioventricular Interval Modulation Therapy (AVIM Therapy) for the treatment of hypertension, the risk factor for death, and Virtue Sirolimus AngioInfusion Balloon (Virtue SAB) for the treatment of atherosclerotic artery disease, the cause of mortality. It has one reportable segment, which consists of the development of clinical and preclinical product candidates through risk-reward sharing partnerships with medical device companies.
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Previous Close:
$4.10
Open:
$4.12
24h Volume:
198.27K
Relative Volume:
0.89
Market Cap:
$243.12M
Revenue:
$33.48M
Net Income/Loss:
$-52.70M
P/E Ratio:
-3.15
EPS:
-1.2889
Net Cash Flow:
$-49.45M
1W Performance:
+9.14%
1M Performance:
-3.56%
6M Performance:
-10.38%
1Y Performance:
+48.72%
1-Day Range:
Value
$4.05
$4.135
1-Week Range:
Value
$3.75
$4.155
52-Week Range:
Value
$2.20
$5.424

Orchestra Biomed Holdings Inc Stock (OBIO) Company Profile

Name
Name
Orchestra Biomed Holdings Inc
Name
Phone
646-343-9298
Name
Address
150 UNION SQUARE DRIVE, NEW HOPE
Name
Employee
86
Name
Twitter
Name
Next Earnings Date
2026-05-11
Name
Latest SEC Filings
Name
OBIO's Discussions on Twitter

Compare OBIO vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
OBIO icon
OBIO
Orchestra Biomed Holdings Inc
4.06 245.51M 33.48M -52.70M -49.45M -1.2889
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
434.52 110.03B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
638.88 67.37B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
806.46 50.76B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
297.45 40.12B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
151.56 32.68B 742.00K -1.37B -1.07B -7.0731

Orchestra Biomed Holdings Inc Stock (OBIO) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-10-25 Initiated TD Cowen Buy
Aug-20-25 Downgrade BTIG Research Buy → Neutral
Mar-20-25 Initiated BTIG Research Buy
Jan-02-25 Initiated Barclays Overweight
Aug-22-24 Initiated H.C. Wainwright Buy
Jul-25-24 Initiated B. Riley Securities Buy
Jan-19-24 Initiated Jefferies Buy
Feb-24-23 Initiated Piper Sandler Overweight
Feb-07-23 Initiated Chardan Capital Markets Buy
View All

Orchestra Biomed Holdings Inc Stock (OBIO) Latest News

pulisher
May 22, 2026

OBIO Q1 2026 Earnings: Narrowed Loss as EPS Surpasses Estimates; Stock Posts Modest DeclineHot Market Picks - Newser

May 22, 2026
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May 22, 2026

Orchestra BioMed Advances FDA Path for Hypertension Device - MyChesCo

May 22, 2026
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May 22, 2026

Orchestra BioMed Targets 2027 Data for Hypertension Trial - MyChesCo

May 22, 2026
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May 21, 2026

Favourable Signals For Orchestra BioMed Holdings: Numerous Insiders Acquired Stock - Yahoo Finance

May 21, 2026
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May 20, 2026

Orchestra BioMed director Jason buys $2,493 in stock - Investing.com UK

May 20, 2026
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May 20, 2026

Orchestra BioMed director Jason buys $2,493 in stock By Investing.com - Investing.com Canada

May 20, 2026
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May 20, 2026

Orchestra BioMed (OBIO) director adds 665 shares in open-market buy - Stock Titan

May 20, 2026
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May 20, 2026

Orchestra BioMed Holdings (OBIO) price target increased by 11.30% to 12.68 - MSN

May 20, 2026
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May 19, 2026

Orchestra BioMed CEO David Hochman buys $18,850 in company stock By Investing.com - Investing.com Nigeria

May 19, 2026
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May 19, 2026

Orchestra BioMed director Aryeh Jason buys $34,986 in stock By Investing.com - Investing.com Nigeria

May 19, 2026
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May 19, 2026

Orchestra BioMed CEO David Hochman buys $18,850 in company stock - Investing.com India

May 19, 2026
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May 19, 2026

Jefferies healthcare fireside chat to feature Orchestra BioMed CEO - Stock Titan

May 19, 2026
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May 19, 2026

Director at Orchestra BioMed (OBIO) buys 8,971 shares in open market - Stock Titan

May 19, 2026
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May 19, 2026

Orchestra BioMed (OBIO) director adds 5,000 shares in open-market buy - Stock Titan

May 19, 2026
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May 19, 2026

B. Riley Cuts Price Target on Orchestra BioMed Holdings to $10 From $12, Keeps Buy Rating - marketscreener.com

May 19, 2026
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May 18, 2026

Orchestra BioMed director Fain buys $82,600 in shares By Investing.com - Investing.com South Africa

May 18, 2026
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May 18, 2026

Orchestra BioMed director Fain buys $82,600 in shares - Investing.com UK

May 18, 2026
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May 18, 2026

Orchestra BioMed (OBIO) director trust buys 20,000 shares - Stock Titan

May 18, 2026
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May 17, 2026

Orchestra BioMed Holdings, Inc. (OBIO) reports Q1 loss, lags revenue estimates - MSN

May 17, 2026
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May 15, 2026

Orchestra BioMed Secures Ligand Funding for Pivotal Trials - MyChesCo

May 15, 2026
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May 15, 2026

H.C. Wainwright Maintains Orchestra BioMed(OBIO.US) With Buy Rating, Maintains Target Price $10 - Moomoo

May 15, 2026
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May 15, 2026

Orchestra BioMed Secures Medtronic Funding for Hypertension Trial - MyChesCo

May 15, 2026
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May 15, 2026

Orchestra BioMed Holdings (OBIO) Receives a Buy from H.C. Wainwright - The Globe and Mail

May 15, 2026
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May 14, 2026

OBIO Reiterated by HC Wainwright & Co. -- Price Target Maintained at $10 - GuruFocus

May 14, 2026
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May 13, 2026

Orchestra BioMed Holdings, Inc. Stock 12‑Month Price Target Raised to $12.57, Implies 210% Upside - TradingView

May 13, 2026
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May 12, 2026

Orchestra BioMed Q1 Loss Narrows, Revenue Falls - Moomoo

May 12, 2026
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May 12, 2026

TradingKey - TradingKey

May 12, 2026
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May 12, 2026

Orchestra BioMed Reports First Quarter 2026 Financial Results and Highlights Recent Business Updates - Investing News Network

May 12, 2026
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May 12, 2026

Orchestra BioMed Holdings, Inc. (OBIO) Reports Q1 Loss, Lags Revenue Estimates - Yahoo Finance

May 12, 2026
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May 12, 2026

Orchestra BioMed Holdings, Inc._March 31, 2026 - SEC.gov

May 12, 2026
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May 12, 2026

Press Release: Orchestra BioMed Reports First Quarter 2026 Financial Results and Highlights Recent Business Updates - Moomoo

May 12, 2026
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May 12, 2026

Orchestra BioMed (NASDAQ: OBIO) Q1 2026 loss, cash and funding update - Stock Titan

May 12, 2026
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May 12, 2026

Orchestra BioMed Holdings, Inc. Reports Earnings Results for the First Quarter Ended March 31, 2026 - marketscreener.com

May 12, 2026
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May 12, 2026

Orchestra BioMed Targeting BACKBEAT Trial Enrollment Completion By End of Q3 2026 and Data Presentation in Q2 2027 - Investing News Network

May 12, 2026
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May 12, 2026

Orchestra BioMed targets Q3 2026 enrollment for hypertension trial By Investing.com - Investing.com Australia

May 12, 2026
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May 12, 2026

Orchestra BioMed targets Q3 2026 enrollment for hypertension trial - Investing.com

May 12, 2026
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May 12, 2026

Orchestra Biomed Holdings Announces Update on Backbeat Global Pivotal Trial Timeline - marketscreener.com

May 12, 2026
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May 08, 2026

Why Orchestra (OBIO) might be the best kept secret in the market (Grinds Higher) 2026-05-08Stock Idea Sharing Hub - newser.com

May 08, 2026
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May 08, 2026

U.S. Earnings Preview: After Market Close May 8 - Moomoo

May 08, 2026

Orchestra Biomed Holdings Inc Stock (OBIO) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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Orchestra Biomed Holdings Inc Stock (OBIO) Insider Trading

Insider Trading Relationship Date Transaction Cost #Shares Value ($) #Shares Total
Aryeh Jason
Director
May 15 '26
Buy
3.90
8,971
34,987
117,453
Hochman David P
See Remarks
May 15 '26
Buy
3.77
5,000
18,850
1,059,029
Fain Eric S
Director
May 14 '26
Buy
4.13
20,000
82,600
91,709
RTW INVESTMENTS, LP
10% Owner
Apr 27 '26
Sale
4.13
32
132
9,556,063
Hochman David P
See Remarks
Mar 13 '26
Buy
4.29
10,000
42,900
1,086,467
Hochman David P
See Remarks
Nov 14 '25
Buy
4.07
5,000
20,350
612,822
Aryeh Jason
Director
Sep 19 '25
Buy
2.45
1,000
2,450
108,482
Fain Eric S
Director
Aug 25 '25
Buy
2.61
5,760
15,034
71,709
Sherman Darren
See Remarks
Aug 25 '25
Buy
2.62
3,000
7,860
926,837
Hochman David P
See Remarks
Aug 21 '25
Buy
2.49
6,000
14,940
651,460
$29.96
price down icon 2.98%
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$92.14
price up icon 1.33%
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ONC ONC
$310.25
price up icon 0.20%
$151.56
price down icon 1.41%
Cap:     |  Volume (24h):