1.86
price down icon5.10%   -0.10
after-market After Hours: 1.87 0.01 +0.54%
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Karyopharm Therapeutics Inc stock is traded at $1.86, with a volume of 903.23K. It is down -5.10% in the last 24 hours and down -74.90% over the past month. Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
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Previous Close:
$1.96
Open:
$1.95
24h Volume:
903.23K
Relative Volume:
0.78
Market Cap:
$42.19M
Revenue:
$151.12M
Net Income/Loss:
$-194.97M
P/E Ratio:
-0.1233
EPS:
-15.0871
Net Cash Flow:
$-59.11M
1W Performance:
+2.76%
1M Performance:
-74.90%
6M Performance:
-81.53%
1Y Performance:
-70.48%
1-Day Range:
Value
$1.83
$1.96
1-Week Range:
Value
$1.82
$2.0153
52-Week Range:
Value
$1.79
$10.99

Karyopharm Therapeutics Inc Stock (KPTI) Company Profile

Name
Name
Karyopharm Therapeutics Inc
Name
Phone
617-658-0600
Name
Address
85 WELLS AVENUE, NEWTON, MA
Name
Employee
228
Name
Twitter
@Karyopharm
Name
Next Earnings Date
2026-08-13
Name
Latest SEC Filings
Name
KPTI's Discussions on Twitter

Compare KPTI vs VRTX, REGN, ARGX, MRNA, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
KPTI icon
KPTI
Karyopharm Therapeutics Inc
1.86 41.28M 151.12M -194.97M -59.11M -15.09
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
547.59 136.93B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
828.50 85.11B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
1,011.11 64.95B 4.16B 1.29B 734.26M 19.58
MRNA icon
MRNA
Moderna Inc
138.89 53.23B 2.23B -3.19B -1.60B -8.1462
RVMD icon
RVMD
Revolution Medicines Inc
211.58 45.38B 742.00K -1.37B -1.07B -7.0731

Karyopharm Therapeutics Inc Stock (KPTI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-10-26 Initiated Rodman & Renshaw Buy
Feb-05-26 Initiated Cantor Fitzgerald Overweight
Oct-13-25 Upgrade H.C. Wainwright Neutral → Buy
Jul-16-25 Downgrade H.C. Wainwright Buy → Neutral
Jul-11-25 Resumed H.C. Wainwright Buy
Jan-19-23 Initiated Piper Sandler Overweight
Nov-04-22 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-09-22 Upgrade JP Morgan Underweight → Neutral
Nov-19-21 Resumed Morgan Stanley Equal-Weight
Aug-06-21 Downgrade JP Morgan Overweight → Neutral
Aug-06-21 Downgrade RBC Capital Mkts Outperform → Sector Perform
Aug-06-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-02-20 Initiated Morgan Stanley Overweight
Mar-04-20 Initiated Barclays Overweight
Jan-17-20 Downgrade Wedbush Outperform → Neutral
Jul-23-19 Upgrade JP Morgan Neutral → Overweight
Jul-05-19 Reiterated H.C. Wainwright Buy
Jul-05-19 Reiterated Robert W. Baird Outperform
Mar-01-19 Downgrade JP Morgan Overweight → Neutral
Feb-28-19 Reiterated BofA/Merrill Underperform
Feb-27-19 Downgrade BofA/Merrill Neutral → Underperform
Jan-03-19 Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18 Initiated B. Riley FBR Buy
Nov-09-18 Upgrade Wedbush Neutral → Outperform
May-24-18 Downgrade Wedbush Outperform → Neutral
Apr-02-18 Resumed Leerink Partners Outperform
Nov-15-17 Resumed H.C. Wainwright Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Sep-08-16 Reiterated H.C. Wainwright Buy
Aug-30-16 Upgrade Jefferies Hold → Buy
Aug-18-16 Initiated H.C. Wainwright Buy
Jun-28-16 Initiated Robert W. Baird Outperform
View All

Karyopharm Therapeutics Inc Stock (KPTI) Latest News

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Aug 21, 2026

Karyopharm’s (KPTI) Big Cancer Bet Faces A Ticking Clock - Yahoo Finance

Aug 21, 2026
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Aug 20, 2026

Conferencia de resultados del 2T de 2026 de Karyopharm (KPTI): foco en la sNDA de selinexor y la liquidez - TradingKey

Aug 20, 2026
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Aug 20, 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc.KPTI - YCharts

Aug 20, 2026
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Aug 20, 2026

Karyopharm (KPTI) Q2 2026 Earnings Call Transcript - AOL.com

Aug 20, 2026
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Aug 19, 2026

KPTI Stock Price and Chart — NASDAQ:KPTI - TradingView

Aug 19, 2026
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Aug 18, 2026

Why Is KPTI Stock Down 69% After-Hours Today? - Stocktwits

Aug 18, 2026
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Aug 16, 2026

Earnings Release: Here's Why Analysts Cut Their Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Price Target To US$6.40 - simplywall.st

Aug 16, 2026
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Aug 14, 2026

RA Capital boosts Karyopharm (KPTI) stake to 9.99% beneficial ownership cap - Stock Titan

Aug 14, 2026
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Aug 14, 2026

Karyopharm Therapeutics (KPTI): Commodore Capital now reports 0.0% ownership - Stock Titan

Aug 14, 2026
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Aug 14, 2026

KPTI|Karyopharm Therapeutics Inc|Price:2.015|Chg%:+0.025 - TradingKey

Aug 14, 2026
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Aug 14, 2026

Karyopharm Therapeutics Inc. Q2 2026 Earnings Call Summary - Yahoo Finance

Aug 14, 2026
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Aug 14, 2026

Karyopharm (KPTI) Ergebniskonferenz Q2 2026: Fokus auf Selinexor-sNDA und Liquidität - TradingKey

Aug 14, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc (KPTI) Earnings, Actual EPS, EPS Estimates & Results - Stocktwits

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc (KPTI) (Q2 2026) Earnings Call Highlights: SENTRY Trial Success and ... - Yahoo! Finance Canada

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc (KPTI) (Q2 2026) Earnings Call Highl - GuruFocus

Aug 13, 2026
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Aug 13, 2026

It's crunch time for Karyopharm as company faces potential default next month - Fierce Pharma

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics has cash to last only into next month - The Business Journals

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Releases Q2 2026 Financial Results - AlphaStreet

Aug 13, 2026
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Aug 13, 2026

Karyopharm Q2 2026 slides: myelofibrosis sNDA planned for August By Investing.com - Investing.com Australia

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Q2 2026 Earnings Call Transcript - marketbeat.com

Aug 13, 2026
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Aug 13, 2026

Karyopharm Q2 2026 slides: myelofibrosis sNDA planned for August - Investing.com

Aug 13, 2026
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Aug 13, 2026

Karyopharm Q2 2026 slides: myelofibrosis data shines amid cash crunch - Investing.com

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc. reports results for the quarter ended June 30Earnings Summary - TradingView

Aug 13, 2026
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Aug 13, 2026

KPTI: Selinexor sNDA for myelofibrosis advances amid strong data, stable sales, and liquidity focus - TradingView

Aug 13, 2026
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Aug 13, 2026

Earnings call transcript: Karyopharm Q2 2026 loss widens as cash pressure mounts - Investing.com

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc. 2026 Q2ResultsEarnings Call Presentation (NASDAQ:KPTI) 2026-08-13 - Seeking Alpha

Aug 13, 2026
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Aug 13, 2026

Form 8K Karyopharm Therapeutics Inc For: 13 August By Investing.com - Investing.com Nigeria

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Reports Q2 2026 Results: Full Earnings Call Transcript - Benzinga

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics (KPTI) Reports Q2 Loss, Beats Revenue Estimates - Yahoo Finance

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc. Reaffirms Earnings Guidance for the Full-Year of 2026 - marketscreener.com

Aug 13, 2026
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Aug 13, 2026

Is Karyopharm Therapeutics Inc (KPTI) Undervalued at 64.1%? Q2 E - GuruFocus

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics Inc. Q2 2026: Revenue $33.4M, Net loss $67M, EPS $(2.32) — 10-Q Summary - TradingView

Aug 13, 2026
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Aug 13, 2026

Karyopharm Therapeutics: Q2 Earnings Snapshot - Barchart.com

Aug 13, 2026
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Aug 13, 2026

Karyopharm Reports $33.4 Million Q2 Revenue and $67 Million Net Loss - Quiver Quantitative

Aug 13, 2026
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Aug 13, 2026

Karyopharm Reports Second Quarter 2026 Financial Results and Highlights Continued Progress Toward Myelofibrosis sNDA Submission - Karyopharm

Aug 13, 2026
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Aug 13, 2026

BRIEF-Karyopharm Therapeutics Q2 Net Income USD -67.023 Million - TradingView

Aug 13, 2026
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Aug 12, 2026

Adage Capital reports 1.54M Karyopharm (KPTI) shares, a 6.78% stake - Stock Titan

Aug 12, 2026
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Aug 12, 2026

Karyopharm Therapeutics Inc Stock Short Interest Rises to 33.51% - Quiver Quantitative

Aug 12, 2026
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Aug 11, 2026

Goldman Sachs Group (KPTI) discloses 6.3% beneficial stake in Karyopharm - Stock Titan

Aug 11, 2026
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Aug 11, 2026

Karyopharm Therapeutics Inc. expected to post a loss of $1.28 a shareEarnings Preview - TradingView

Aug 11, 2026
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Aug 10, 2026

Karyopharm to Report Second Quarter 2026 Financial Results on August 13, 2026 - Karyopharm

Aug 10, 2026
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Aug 10, 2026

Karyopharm’s Aug. 13 results call will include slides online - Stock Titan

Aug 10, 2026
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Aug 10, 2026

Karyopharm Therapeutics (KPTI) Drops 7.6% to $1.96, Testing Key Support at $1.86Mutual Fund Flow - vinanet.vn

Aug 10, 2026
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Aug 06, 2026

Myelofibrosis Combo Advances as Karyopharm Preps August sNDA - Streetwise Reports

Aug 06, 2026
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Aug 04, 2026

Analysts Have Conflicting Sentiments on These Healthcare Companies: Teladoc (TDOC) and Karyopharm Therapeutics (KPTI) - The Globe and Mail

Aug 04, 2026
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Aug 03, 2026

Karyopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) - Karyopharm

Aug 03, 2026
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Aug 03, 2026

Weekly Recap: XPORT-EC-042 misses PFS endpoint and SENTRY sNDA reports SVR35 - TradingView

Aug 03, 2026
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Aug 02, 2026

KPTI Stock Crashes As Trial Failure Triggers Legal Scrutiny - StocksToTrade

Aug 02, 2026
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Aug 01, 2026

KPTI Stock Collapses As Trial Failure Triggers Downgrades And Legal Scrutiny - StocksToTrade

Aug 01, 2026
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Jul 31, 2026

Low coffers, failed endometrial cancer trial: Karyopharm down 72% - bioworld.com

Jul 31, 2026
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Jul 31, 2026

Jefferies Initiates Karyopharm Therapeutics(KPTI.US) With Buy Rating, Announces Target Price $11 - moomoo.com

Jul 31, 2026

Karyopharm Therapeutics Inc Stock (KPTI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$123.98
price up icon 0.00%
$61.33
price up icon 0.03%
$112.82
price down icon 3.22%
$236.01
price down icon 0.09%
ONC ONC
$371.98
price down icon 0.66%
$211.58
price up icon 1.01%
Cap:     |  Volume (24h):