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Karyopharm Therapeutics Inc stock is traded at $10.34, with a volume of 320.24K. It is up +1.37% in the last 24 hours and up +13.50% over the past month. Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
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Previous Close:
$10.20
Open:
$10.3
24h Volume:
320.24K
Relative Volume:
0.66
Market Cap:
$234.33M
Revenue:
$146.07M
Net Income/Loss:
$-196.04M
P/E Ratio:
-0.6221
EPS:
-16.621
Net Cash Flow:
$-75.37M
1W Performance:
+7.71%
1M Performance:
+13.50%
6M Performance:
+19.12%
1Y Performance:
+106.80%
1-Day Range:
Value
$9.88
$10.59
1-Week Range:
Value
$9.20
$10.86
52-Week Range:
Value
$3.6503
$10.99

Karyopharm Therapeutics Inc Stock (KPTI) Company Profile

Name
Name
Karyopharm Therapeutics Inc
Name
Phone
617-658-0600
Name
Address
85 WELLS AVENUE, NEWTON, MA
Name
Employee
228
Name
Twitter
@Karyopharm
Name
Next Earnings Date
2026-08-10
Name
Latest SEC Filings
Name
KPTI's Discussions on Twitter

Compare KPTI vs VRTX, REGN, ARGX, ALNY, RVMD

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
KPTI icon
KPTI
Karyopharm Therapeutics Inc
10.34 234.33M 146.07M -196.04M -75.37M -16.62
VRTX icon
VRTX
Vertex Pharmaceuticals Inc
485.39 123.19B 12.34B 4.34B 3.71B 16.87
REGN icon
REGN
Regeneron Pharmaceuticals Inc
664.52 69.67B 14.92B 4.42B 3.79B 41.04
ARGX icon
ARGX
Argen X Se Adr
877.62 54.58B 4.16B 1.29B 734.26M 19.58
ALNY icon
ALNY
Alnylam Pharmaceuticals Inc
298.76 39.89B 4.29B 577.22M 641.34M 4.2086
RVMD icon
RVMD
Revolution Medicines Inc
186.88 39.73B 742.00K -1.37B -1.07B -7.0731

Karyopharm Therapeutics Inc Stock (KPTI) Upgrades & Downgrades

Date Action Analyst Rating Change
Mar-10-26 Initiated Rodman & Renshaw Buy
Feb-05-26 Initiated Cantor Fitzgerald Overweight
Oct-13-25 Upgrade H.C. Wainwright Neutral → Buy
Jul-16-25 Downgrade H.C. Wainwright Buy → Neutral
Jul-11-25 Resumed H.C. Wainwright Buy
Jan-19-23 Initiated Piper Sandler Overweight
Nov-04-22 Upgrade RBC Capital Mkts Sector Perform → Outperform
Feb-09-22 Upgrade JP Morgan Underweight → Neutral
Nov-19-21 Resumed Morgan Stanley Equal-Weight
Aug-06-21 Downgrade JP Morgan Overweight → Neutral
Aug-06-21 Downgrade RBC Capital Mkts Outperform → Sector Perform
Aug-06-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-02-20 Initiated Morgan Stanley Overweight
Mar-04-20 Initiated Barclays Overweight
Jan-17-20 Downgrade Wedbush Outperform → Neutral
Jul-23-19 Upgrade JP Morgan Neutral → Overweight
Jul-05-19 Reiterated H.C. Wainwright Buy
Jul-05-19 Reiterated Robert W. Baird Outperform
Mar-01-19 Downgrade JP Morgan Overweight → Neutral
Feb-28-19 Reiterated BofA/Merrill Underperform
Feb-27-19 Downgrade BofA/Merrill Neutral → Underperform
Jan-03-19 Upgrade BofA/Merrill Underperform → Neutral
Dec-03-18 Initiated B. Riley FBR Buy
Nov-09-18 Upgrade Wedbush Neutral → Outperform
May-24-18 Downgrade Wedbush Outperform → Neutral
Apr-02-18 Resumed Leerink Partners Outperform
Nov-15-17 Resumed H.C. Wainwright Buy
Sep-15-17 Initiated RBC Capital Mkts Outperform
Sep-08-16 Reiterated H.C. Wainwright Buy
Aug-30-16 Upgrade Jefferies Hold → Buy
Aug-18-16 Initiated H.C. Wainwright Buy
Jun-28-16 Initiated Robert W. Baird Outperform
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Karyopharm Therapeutics Inc Stock (KPTI) Latest News

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Jul 09, 2026

Karyopharm stock trades steadily as investors watch Selinexor franchise - ad-hoc-news.de

Jul 09, 2026
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Jul 09, 2026

RBC Capital Maintains Karyopharm Therapeutics(KPTI.US) With Buy Rating, Maintains Target Price $16 - Moomoo

Jul 09, 2026
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Jul 08, 2026

Karyopharm Therapeutics (KPTI) Q2 2024 earnings summary - Quartr

Jul 08, 2026
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Jul 07, 2026

Karyopharm Therapeutics faces a data setback as investors weigh late-stage cancer pipeline - ad-hoc-news.de

Jul 07, 2026
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Jul 05, 2026

KPTIKaryopharm Therapeutics Inc Latest SEC Filings - Finviz

Jul 05, 2026
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Jul 02, 2026

KPTI News | KARYOPHARM THERAPEUTICS INC (NASDAQ:KPTI) - ChartMill

Jul 02, 2026
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Jul 01, 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(C)(4) - TradingView

Jul 01, 2026
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Jul 01, 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) - PR Newswire

Jul 01, 2026
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Jul 01, 2026

Karyopharm gives 4 new hires stock awards vesting over 3 years - Stock Titan

Jul 01, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS:KPTI) added to Russell Small Cap Comp Growth Benchmark - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 2000 Index - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 2000 Value Benchmark - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 2000 Growth Benchmark - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 3000E Index - marketscreener.com

Jun 29, 2026
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Jun 29, 2026

Karyopharm Therapeutics Inc.(NasdaqGS:KPTI) added to Russell 3000E Growth Benchmark - marketscreener.com

Jun 29, 2026
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Jun 28, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 3000 Growth Benchmark - marketscreener.com

Jun 28, 2026
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Jun 28, 2026

Enterprise value to EBITDA forward of Karyopharm Therapeutics Inc. – NASDAQ:KPTI - TradingView

Jun 28, 2026
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Jun 28, 2026

Price to sales forward of Karyopharm Therapeutics Inc. – NASDAQ:KPTI - TradingView

Jun 28, 2026
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Jun 28, 2026

Karyopharm Therapeutics Inc.(NasdaqGS: KPTI) added to Russell 2000 Dynamic Index - marketscreener.com

Jun 28, 2026
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Jun 28, 2026

Price to earnings forward of Karyopharm Therapeutics Inc. – NASDAQ:KPTI - TradingView

Jun 28, 2026
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Jun 28, 2026

Enterprise value to revenue forward of Karyopharm Therapeutics Inc. – NASDAQ:KPTI - TradingView

Jun 28, 2026
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Jun 26, 2026

Karyopharm Therapeutics (KPTI) Stock Price, News & Analysis $KPTI - MarketBeat

Jun 26, 2026
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Jun 25, 2026

Karyopharm Therapeutics, Inc. Actuals & Estimates (NASDAQ:KPTI) - TradingView

Jun 25, 2026
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Jun 25, 2026

25K0 Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 25, 2026

KPTI Forecast — Price Target — Prediction for 2027 - TradingView

Jun 25, 2026
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Jun 25, 2026

Karyopharm Therapeutics (KPTI) Stock Sees Split Analyst Revisions After Phase 3 Trial Update - Yahoo Finance

Jun 25, 2026
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Jun 23, 2026

Karyopharm Therapeutics Inc (KPTI) Technical Analysis: Support, Resistance, Indicators & Moving Averages - TradingKey

Jun 23, 2026
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Jun 22, 2026

Dyne Therapeutics Appoints Barry Greene to Board of Directors - GlobeNewswire

Jun 22, 2026
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Jun 18, 2026

Karyopharm Therapeutics Inc (KPTI) Earnings Forecast: Future EPS & Revenue Growth Estimates - TradingKey

Jun 18, 2026
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Jun 18, 2026

Karyopharm: Xpovio Revenue Stagnation And Toxicity Concerns Justify Sell - Seeking Alpha

Jun 18, 2026
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Jun 18, 2026

Karyopharm Therapeutics Inc (KPTI) Valuation: PE, PB & Fair Value Analysis - TradingKey

Jun 18, 2026
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Jun 18, 2026

H.C. Wainwright reiterates Karyopharm stock rating on trial data By Investing.com - Investing.com Canada

Jun 18, 2026
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Jun 18, 2026

Karyopharm Therapeutics Inc (KPTI) Risk Assessment: Volatility, Financial Risk & Investment Risk - TradingKey

Jun 18, 2026
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Jun 18, 2026

Karyopharm Therapeutics Inc (KPTI) Institutional Confidence - TradingKey

Jun 18, 2026
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Jun 18, 2026

H.C. Wainwright Maintains Karyopharm Therapeutics(KPTI.US) With Buy Rating, Maintains Target Price $13 - Moomoo

Jun 18, 2026
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Jun 17, 2026

Karyopharm Therapeutics Inc (KPTI) Dividends & Stock Splits: Historical Payouts and Event Timeline - TradingKey

Jun 17, 2026
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Jun 17, 2026

Karyopharm Therapeutics Inc (KPTI) Shareholder Structure: Major Shareholders & Institutional Holdings - TradingKey

Jun 17, 2026
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Jun 17, 2026

Karyopharm Therapeutics Inc (KPTI) Financial Health: Profitability & Balance Sheet Analysis - TradingKey

Jun 17, 2026
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Jun 17, 2026

Karyopharm Therapeutics Inc (KPTI) Revenue Breakdown: Business Segments, Regional Revenue & Profit Contribution - TradingKey

Jun 17, 2026
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Jun 16, 2026

Karyopharm Therapeutics presents new Phase 3 SENTRY trial data in myelofibrosis at EHA - Traders Union

Jun 16, 2026
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Jun 14, 2026

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress - TradingView

Jun 14, 2026
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Jun 14, 2026

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor (NEXPOVIO®) Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress - GlobeNewswire Inc.

Jun 14, 2026
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Jun 13, 2026

Karyopharm Therapeutics secures EHA Congress acclaim for late-breaking SENTRY trial update - Traders Union

Jun 13, 2026
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Jun 09, 2026

Cantor Fitzgerald reiterates Overweight on Karyopharm stock - Investing.com UK

Jun 09, 2026
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Jun 09, 2026

Cantor Fitzgerald reiterates Overweight on Karyopharm stock By Investing.com - Investing.com South Africa

Jun 09, 2026
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Jun 07, 2026

How The Investment Story Is Evolving For Karyopharm Therapeutics (KPTI) - Yahoo Finance

Jun 07, 2026
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Jun 05, 2026

T. Rowe Price (KPTI) files Schedule 13G/A showing 6.6% position - Stock Titan

Jun 05, 2026
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Jun 04, 2026

KPTI: Phase III data in myelofibrosis and endometrial cancer signal major advances and rapid adoption - TradingView

Jun 04, 2026
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Jun 03, 2026

Karyopharm to Participate in Webcast Featuring Endometrial Cancer Key Opinion Leader on June 8, 2026 - Karyopharm

Jun 03, 2026
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Jun 03, 2026

Cancer expert joins Karyopharm's June 8 investor webcast - Stock Titan

Jun 03, 2026
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Jun 02, 2026

Karyopharm Therapeutics Inc. (KPTI) Discusses Phase III SENTRY Trial Results of Selinexor Plus Ruxolitinib in MyelofibrosisSlideshow (NASDAQ:KPTI) 2026-06-02 - Seeking Alpha

Jun 02, 2026

Karyopharm Therapeutics Inc Stock (KPTI) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$56.43
price down icon 2.64%
$115.61
price down icon 2.24%
$35.97
price down icon 2.28%
$68.27
price down icon 10.83%
ONC ONC
$298.70
price down icon 1.36%
$186.88
price down icon 2.22%
Cap:     |  Volume (24h):