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Ionis Pharmaceuticals Inc stock is traded at $79.50, with a volume of 797.70K. It is down -2.89% in the last 24 hours and down -1.12% over the past month. Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.
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Previous Close:
$81.79
Open:
$81.71
24h Volume:
797.70K
Relative Volume:
0.33
Market Cap:
$12.88B
Revenue:
$705.14M
Net Income/Loss:
$-453.90M
P/E Ratio:
-26.15
EPS:
-3.04
Net Cash Flow:
$-551.29M
1W Performance:
+4.06%
1M Performance:
-1.12%
6M Performance:
+87.42%
1Y Performance:
+130.50%
1-Day Range:
Value
$79.34
$82.20
1-Week Range:
Value
$74.20
$82.20
52-Week Range:
Value
$23.95
$86.15

Ionis Pharmaceuticals Inc Stock (IONS) Company Profile

Name
Name
Ionis Pharmaceuticals Inc
Name
Phone
(760) 931-9200
Name
Address
2855 GAZELLE COURT, CARLSBAD, CA
Name
Employee
927
Name
Twitter
@ionispharma
Name
Next Earnings Date
2024-11-06
Name
Latest SEC Filings
Name
IONS's Discussions on Twitter

Compare IONS with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
IONS
Ionis Pharmaceuticals Inc
79.50 13.25B 705.14M -453.90M -551.29M -3.04
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
463.63 118.58B 11.74B 3.68B 3.34B 14.19
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
749.34 79.40B 14.25B 4.58B 3.88B 41.77
Biotechnology icon
ARGX
Argen X Se Adr
811.57 51.18B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
360.84 48.88B 3.21B 43.57M 221.36M 0.2405
Biotechnology icon
ONC
Beone Medicines Ltd Adr
339.19 37.49B 4.98B 69.59M 525.67M 0.5197

Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades

Date Action Analyst Rating Change
Oct-08-25 Upgrade JP Morgan Neutral → Overweight
Sep-26-25 Upgrade Goldman Sell → Neutral
Sep-03-25 Upgrade BMO Capital Markets Market Perform → Outperform
Jul-31-25 Upgrade Morgan Stanley Equal-Weight → Overweight
Jul-01-25 Upgrade Barclays Equal Weight → Overweight
Apr-07-25 Initiated H.C. Wainwright Buy
Mar-31-25 Initiated Redburn Atlantic Neutral
Aug-02-24 Downgrade BMO Capital Markets Outperform → Market Perform
Jul-24-24 Upgrade Leerink Partners Market Perform → Outperform
Jul-16-24 Resumed Jefferies Buy
Jun-14-24 Upgrade Bernstein Underperform → Mkt Perform
Apr-10-24 Upgrade Wolfe Research Peer Perform → Outperform
Jan-02-24 Upgrade BofA Securities Neutral → Buy
Oct-23-23 Upgrade BofA Securities Underperform → Neutral
Sep-29-23 Initiated Raymond James Strong Buy
Jul-31-23 Upgrade Citigroup Neutral → Buy
Jun-07-23 Resumed Piper Sandler Overweight
May-04-23 Upgrade Citigroup Sell → Neutral
Mar-21-23 Initiated Bernstein Underperform
Dec-21-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Sep-09-22 Resumed Morgan Stanley Overweight
Jul-18-22 Resumed Oppenheimer Outperform
Mar-31-22 Resumed Piper Sandler Overweight
Mar-01-22 Initiated Citigroup Sell
Mar-01-22 Initiated Guggenheim Buy
Feb-01-22 Downgrade BofA Securities Buy → Underperform
Dec-14-21 Upgrade William Blair Mkt Perform → Outperform
May-07-21 Upgrade UBS Sell → Neutral
Mar-01-21 Upgrade Barclays Underweight → Equal Weight
Dec-16-20 Initiated UBS Sell
Dec-15-20 Upgrade Cowen Market Perform → Outperform
Sep-14-20 Resumed JP Morgan Neutral
Sep-02-20 Initiated The Benchmark Company Hold
Jun-01-20 Resumed Oppenheimer Outperform
May-13-20 Initiated RBC Capital Mkts Outperform
Mar-05-20 Initiated Citigroup Buy
Dec-13-19 Initiated Oppenheimer Outperform
Nov-13-19 Initiated BofA/Merrill Buy
Nov-07-19 Downgrade Morgan Stanley Equal-Weight → Underweight
Sep-10-19 Upgrade Bernstein Mkt Perform → Outperform
Aug-08-18 Reiterated Stifel Hold
Aug-07-18 Reiterated Stifel Hold
May-08-18 Downgrade Evercore ISI Outperform → In-line
Oct-06-17 Resumed Goldman Sell
Aug-17-17 Initiated Evercore ISI Outperform
Aug-09-17 Reiterated Stifel Hold
Mar-10-17 Downgrade Goldman Neutral → Sell
Dec-28-16 Reiterated BMO Capital Markets Outperform
Dec-27-16 Reiterated Leerink Partners Mkt Perform
View All

Ionis Pharmaceuticals Inc Stock (IONS) Latest News

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Jan 22, 2026

Ionis' Dawnzera Gets EU Approval for Hereditary Angioedema - Finviz

Jan 22, 2026
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Jan 22, 2026

Ionis, Otsuka win EU nod for hereditary angioedema therapy - MSN

Jan 22, 2026
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Jan 22, 2026

Massachusetts Financial Services Co. MA Increases Position in Ionis Pharmaceuticals, Inc. $IONS - MarketBeat

Jan 22, 2026
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Jan 21, 2026

Spinocerebellar Ataxias Pipeline 2025: Therapies Under Investigation, Clinical Trials Milestones, and FDA Approvals by DelveInsight | Biogen Inc, BioXcel Corp, Celavie Biosciences, Ionis Pharma - Barchart.com

Jan 21, 2026
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Jan 21, 2026

Amyloidosis Therapeutic Market to Worth Over US$ 6.37 Billion by 2033 | Astute Analytica - GlobeNewswire Inc.

Jan 21, 2026
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Jan 21, 2026

Ionis, Otsuka win EU nod for hereditary angioedema drug (IONS) - Seeking Alpha

Jan 21, 2026
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Jan 21, 2026

Ionis Pharmaceuticals (IONS) Gains EU Approval for Dawnzera - GuruFocus

Jan 21, 2026
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Jan 21, 2026

DAWNZERA™ (donidalorsen) approved in the European Union for hereditary angioedema (HAE) - Business Wire

Jan 21, 2026
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Jan 20, 2026

Insider Selling: Ionis Pharmaceuticals (NASDAQ:IONS) EVP Sells 12,922 Shares of Stock - MarketBeat

Jan 20, 2026
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Jan 20, 2026

Ionis Pharmaceuticals (NASDAQ:IONS) EVP Sells $697,045.44 in Stock - MarketBeat

Jan 20, 2026
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Jan 20, 2026

Eric Swayze Sells 9,884 Shares of Ionis Pharmaceuticals (NASDAQ:IONS) Stock - MarketBeat

Jan 20, 2026
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Jan 20, 2026

Ionis Pharmaceuticals (NASDAQ:IONS) EVP C Frank Bennett Sells 8,977 Shares - MarketBeat

Jan 20, 2026
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Jan 20, 2026

Ionis Pharmaceuticals Executives Sell Shares - TradingView — Track All Markets

Jan 20, 2026
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Jan 20, 2026

Ionis Pharmaceuticals Executives Engage in Stock Transactions - TradingView — Track All Markets

Jan 20, 2026
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Jan 20, 2026

Big Picture: Is Ionis Pharmaceuticals Inc likely to announce a buyback2025 Pullback Review & Weekly Return Optimization Alerts - baoquankhu1.vn

Jan 20, 2026
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Jan 20, 2026

Ionis: Expected 2026 Launch Of Olezarsen In SHTG To Spur Leap In Revenue Growth - Seeking Alpha

Jan 20, 2026
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Jan 20, 2026

United States Transthyretin Amyloid Cardiomyopathy Market - openPR.com

Jan 20, 2026
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Jan 20, 2026

Hereditary Angioedema Market Poised for Strong Growth, Valued - openPR.com

Jan 20, 2026
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Jan 18, 2026

Ionis Pharmaceuticals, Inc. $IONS Shares Sold by Sumitomo Mitsui Trust Group Inc. - MarketBeat

Jan 18, 2026
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Jan 18, 2026

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Receives Average Recommendation of "Moderate Buy" from Brokerages - MarketBeat

Jan 18, 2026
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Jan 17, 2026

Ionis Pharmaceuticals (NASDAQ:IONS) Shares Pass Above 200 Day Moving AverageShould You Sell? - MarketBeat

Jan 17, 2026
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Jan 15, 2026

Spinal Muscular Atrophy Pipeline 2025: FDA Approvals and Clinical Trials Landscape with MOA and ROA Highlights by DelveInsight | Genentech Inc, Chugai Pharma, Cytokinetics Inc., Ionis Pharma, Genzyme - Barchart.com

Jan 15, 2026
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Jan 14, 2026

Insider Trends: Does Ionis Pharmaceuticals Inc have consistent dividend growthJuly 2025 Trade Ideas & Reliable Breakout Stock Forecasts - baoquankhu1.vn

Jan 14, 2026
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Jan 14, 2026

Revenue Check: Can Ionis Pharmaceuticals Inc scale operations efficiently2025 Institutional Moves & Low Risk High Reward Ideas - baoquankhu1.vn

Jan 14, 2026
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Jan 14, 2026

JPM26: Tryngolza set to become first wholly owned Ionis blockbuster - Yahoo Finance

Jan 14, 2026
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Jan 13, 2026

CEO Change: Can Ionis Pharmaceuticals Inc outperform in the next rally2025 Pullback Review & Long-Term Growth Portfolio Plans - baoquankhu1.vn

Jan 13, 2026
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Jan 13, 2026

Assessing Ionis Pharmaceuticals (IONS) Valuation After A Strong 1 Year Shareholder Return - Yahoo Finance

Jan 13, 2026
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Jan 13, 2026

Trend Recap: Why retail investors favor Ionis Pharmaceuticals Inc. stockJuly 2025 Setups & Long-Term Capital Growth Strategies - Bộ Nội Vụ

Jan 13, 2026
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Jan 12, 2026

How reliable is Ionis Pharmaceuticals Inc. (ISI) stock dividend growthSector Rotation Strategies & Free Unmatched Market Performance - bollywoodhelpline.com

Jan 12, 2026
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Jan 12, 2026

Lobbying Update: $60,000 of IONIS PHARMACEUTICALS INC. lobbying was just disclosed - Quiver Quantitative

Jan 12, 2026
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Jan 12, 2026

Ionis well-positioned for continued momentum and substantial value creation in 2026 with two new independent launches and several pivotal data readouts - marketscreener.com

Jan 12, 2026
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Jan 12, 2026

Precision Trading with Ionis Pharmaceuticals Inc. (IONS) Risk Zones - Stock Traders Daily

Jan 12, 2026
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Jan 10, 2026

Will Ionis Pharmaceuticals Inc. stock outperform international peersBull Run & Weekly Watchlist for Hot Stocks - ulpravda.ru

Jan 10, 2026
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Jan 09, 2026

Ionis Pharmaceuticals EVP Devers sells $3.7m in shares By Investing.com - Investing.com Nigeria

Jan 09, 2026
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Jan 09, 2026

Insider Sell Alert: Shannon Devers Sells 44,199 Shares of Ionis Pharmaceuticals Inc (IONS) - GuruFocus

Jan 09, 2026
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Jan 09, 2026

Insider Selling: Ionis Pharmaceuticals (NASDAQ:IONS) EVP Sells 44,199 Shares of Stock - MarketBeat

Jan 09, 2026
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Jan 09, 2026

Ionis Pharmaceuticals (IONS) Reports Q3 Loss, Beats Revenue Estimates - sharewise.com

Jan 09, 2026
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Jan 09, 2026

Ionis chalks up rare disease win with zilganersen - The Pharma Letter

Jan 09, 2026
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Jan 08, 2026

How resilient is Ionis Pharmaceuticals Inc. stock in market downturns2025 Price Action Summary & Weekly Stock Breakout Alerts - Улправда

Jan 08, 2026
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Jan 08, 2026

Will Ionis Pharmaceuticals Inc. (ISI) stock benefit from infrastructure billEarnings Recap Report & Accurate Buy Signal Alerts - Улправда

Jan 08, 2026
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Jan 08, 2026

Momentum Shift: Will Ionis Pharmaceuticals Inc. stock gain from government policiesJuly 2025 Analyst Calls & Expert Verified Stock Movement Alerts - Улправда

Jan 08, 2026
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Jan 08, 2026

Will Ionis Pharmaceuticals Inc. stock recover faster than peersEntry Point & Daily Risk Controlled Trade Plans - ulpravda.ru

Jan 08, 2026
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Jan 08, 2026

Book value per share of Ionis Pharmaceuticals, Inc. – SWB:ISI - TradingView — Track All Markets

Jan 08, 2026
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Jan 08, 2026

How Ionis Pharmaceuticals Inc. stock compares to industry benchmarksGap Down & Technical Pattern Based Buy Signals - ulpravda.ru

Jan 08, 2026
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Jan 08, 2026

Can Ionis Pharmaceuticals Inc. stock sustain market leadershipTrade Entry Summary & Community Consensus Picks - Улправда

Jan 08, 2026
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Jan 08, 2026

GSK's Chronic Hepatitis B Drug Meets Goals in Two Late-Stage Studies - Nasdaq

Jan 08, 2026
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Jan 08, 2026

Sentiment Review: Why Ionis Pharmaceuticals Inc. stock could see breakout soon - Улправда

Jan 08, 2026
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Jan 08, 2026

Why Ionis Pharmaceuticals Inc. stock is a value investor pickTrade Exit Report & Risk Adjusted Buy/Sell Alerts - Улправда

Jan 08, 2026
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Jan 08, 2026

Ionis Pharmaceuticals stock hits 52-week high at 83.62 USD By Investing.com - Investing.com Nigeria

Jan 08, 2026
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Jan 08, 2026

Ionis Pharmaceuticals (IONS) Is Up 5.1% After Hepatitis B Drug Hits Phase 3 GoalsHas The Bull Case Changed? - Sahm

Jan 08, 2026
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Jan 07, 2026

Why Ionis Pharmaceuticals (IONS) Is Up 5.1% After Hepatitis B Drug Hits Phase 3 Goals And What's Next - Yahoo Finance

Jan 07, 2026

Ionis Pharmaceuticals Inc Stock (IONS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$100.60
price down icon 4.38%
$33.77
price up icon 1.95%
$118.82
price up icon 0.01%
$116.03
price down icon 2.22%
$155.69
price down icon 3.02%
biotechnology ONC
$338.76
price down icon 0.05%
Cap:     |  Volume (24h):