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39.84
0.89%
0.3262
Ionis Pharmaceuticals Inc stock is traded at $39.84, with a volume of 2.48M.
It is up +0.89% in the last 24 hours and up +18.96% over the past month.
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.
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Previous Close:
$39.51
Open:
$40.251
24h Volume:
2.48M
Relative Volume:
1.54
Market Cap:
$5.86B
Revenue:
$705.14M
Net Income/Loss:
$-453.90M
P/E Ratio:
-13.10
EPS:
-3.04
Net Cash Flow:
$-551.29M
1W Performance:
+0.56%
1M Performance:
+18.96%
6M Performance:
+14.02%
1Y Performance:
-15.38%
1-Day Range:
$39.75
$40.82
1-Week Range:
$38.98
$40.82
52-Week Range:
$23.95
$52.34
Ionis Pharmaceuticals Inc Stock (IONS) Company Profile
Name
Ionis Pharmaceuticals Inc
Sector
Industry
Phone
(760) 931-9200
Address
2855 GAZELLE COURT, CARLSBAD, CA
Compare IONS with other stocks
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
IONS
Ionis Pharmaceuticals Inc
|
39.76 | 5.86B | 705.14M | -453.90M | -551.29M | -3.04 |
|
VRTX
Vertex Pharmaceuticals Inc
|
452.79 | 115.95B | 11.10B | -988.90M | -1.26B | -3.92 |
|
REGN
Regeneron Pharmaceuticals Inc
|
538.79 | 56.52B | 14.09B | 4.50B | 2.96B | 39.28 |
|
ALNY
Alnylam Pharmaceuticals Inc
|
323.05 | 39.44B | 2.35B | -269.70M | -75.39M | -2.09 |
|
ARGX
Argen X Se Adr
|
547.71 | 35.14B | 2.58B | 1.06B | -1.28B | 16.33 |
|
ONC
Beone Medicines Ltd Adr
|
243.21 | 28.51B | 3.81B | -644.79M | -669.77M | -6.24 |
Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Apr-07-25 | Initiated | H.C. Wainwright | Buy |
| Mar-31-25 | Initiated | Redburn Atlantic | Neutral |
| Aug-02-24 | Downgrade | BMO Capital Markets | Outperform → Market Perform |
| Jul-24-24 | Upgrade | Leerink Partners | Market Perform → Outperform |
| Jul-16-24 | Resumed | Jefferies | Buy |
| Jun-14-24 | Upgrade | Bernstein | Underperform → Mkt Perform |
| Apr-10-24 | Upgrade | Wolfe Research | Peer Perform → Outperform |
| Jan-02-24 | Upgrade | BofA Securities | Neutral → Buy |
| Oct-23-23 | Upgrade | BofA Securities | Underperform → Neutral |
| Sep-29-23 | Initiated | Raymond James | Strong Buy |
| Jul-31-23 | Upgrade | Citigroup | Neutral → Buy |
| Jun-07-23 | Resumed | Piper Sandler | Overweight |
| May-04-23 | Upgrade | Citigroup | Sell → Neutral |
| Mar-21-23 | Initiated | Bernstein | Underperform |
| Dec-21-22 | Downgrade | Morgan Stanley | Overweight → Equal-Weight |
| Sep-09-22 | Resumed | Morgan Stanley | Overweight |
| Jul-18-22 | Resumed | Oppenheimer | Outperform |
| Mar-31-22 | Resumed | Piper Sandler | Overweight |
| Mar-01-22 | Initiated | Citigroup | Sell |
| Mar-01-22 | Initiated | Guggenheim | Buy |
| Feb-01-22 | Downgrade | BofA Securities | Buy → Underperform |
| Dec-14-21 | Upgrade | William Blair | Mkt Perform → Outperform |
| May-07-21 | Upgrade | UBS | Sell → Neutral |
| Mar-01-21 | Upgrade | Barclays | Underweight → Equal Weight |
| Dec-16-20 | Initiated | UBS | Sell |
| Dec-15-20 | Upgrade | Cowen | Market Perform → Outperform |
| Sep-14-20 | Resumed | JP Morgan | Neutral |
| Sep-02-20 | Initiated | The Benchmark Company | Hold |
| Jun-01-20 | Resumed | Oppenheimer | Outperform |
| May-13-20 | Initiated | RBC Capital Mkts | Outperform |
| Mar-05-20 | Initiated | Citigroup | Buy |
| Dec-13-19 | Initiated | Oppenheimer | Outperform |
| Nov-13-19 | Initiated | BofA/Merrill | Buy |
| Nov-07-19 | Downgrade | Morgan Stanley | Equal-Weight → Underweight |
| Sep-10-19 | Upgrade | Bernstein | Mkt Perform → Outperform |
| Aug-08-18 | Reiterated | Stifel | Hold |
| Aug-07-18 | Reiterated | Stifel | Hold |
| May-08-18 | Downgrade | Evercore ISI | Outperform → In-line |
| Oct-06-17 | Resumed | Goldman | Sell |
| Aug-17-17 | Initiated | Evercore ISI | Outperform |
| Aug-09-17 | Reiterated | Stifel | Hold |
| Mar-10-17 | Downgrade | Goldman | Neutral → Sell |
| Dec-28-16 | Reiterated | BMO Capital Markets | Outperform |
| Dec-27-16 | Reiterated | Leerink Partners | Mkt Perform |
View All
Ionis Pharmaceuticals Inc Stock (IONS) Latest News
Global RNAi Technology Market: Opportunities in Targeted - openPR.com
Antisense Oligonucleotides Market is expected to reach US$ - openPR.com
Ionis announces leadership change as chief development officer plans retirement - Investing.com India
Ionis announces Dr. Richard Geary, chief development officer, to - GuruFocus
Ionis announces leadership change as chief development officer plans retirement By Investing.com - Investing.com South Africa
JP Morgan Maintains Neutral Rating, Raises Price Target for Ionis Pharmaceuticals (IONS) | IONS Stock News - GuruFocus
Analyst Expectations For Ionis Pharmaceuticals's Future - Benzinga
Ionis Pharmaceuticals (IONS) Announces Leadership Change in Development | IONS Stock News - GuruFocus
Ionis announces Dr. Richard Geary, chief development officer, to retire; Dr. Holly Kordasiewicz to assume role in January 2026 | IONS Stock News - GuruFocus
Ionis Pharmaceuticals Announces Dr Richard Geary, Chief Development Officer, To Retire - MarketScreener
Ionis announces Dr. Richard Geary, chief development officer, to retire; Dr. Holly Kordasiewicz to assume role in January 2026 - The Joplin Globe
Ionis Pharmaceuticals Inc. filed SEC Form 8-K: Leadership Update, Financial Statements and Exhibits - Quantisnow
JPMorgan Adjusts Ionis Pharmaceuticals (IONS) Price Target to $4 - GuruFocus
JPMorgan Adjusts Ionis Pharmaceuticals (IONS) Price Target to $48 | IONS Stock News - GuruFocus
Ionis doses first subject in Phase III trial of Angelman syndrome therapy - Yahoo Finance
First patient dosed in pivotal Phase 3 REVEAL clinical study of ION582 in Angelman syndrome | IONS Stock News - GuruFocus
Ionis begins phase 3 trial of Angelman syndrome treatment By Investing.com - Investing.com Canada
Ionis Pharmaceuticals (IONS) Advances with Phase 3 REVEAL Study for Angelman Syndrome | IONS Stock News - GuruFocus
First patient dosed in pivotal Phase 3 REVEAL clinical study of ION582 in Angelman syndrome - Yahoo Finance
Ionis Pharmaceuticals reports annual meeting results - Investing.com Australia
Ionis Pharmaceuticals reports annual meeting results By Investing.com - Investing.com Nigeria
Ionis Pharmaceuticals Holds Annual Stockholders Meeting - TipRanks
Day 8 of Gains Streak for Ionis Pharmaceuticals Stock with 13% Return (vs. 5.1% YTD) [6/9/2025] - Trefis
Breakthrough Growth in Transthyretin Amyloid Cardiomyopathy - openPR.com
Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Given Average Recommendation of “Moderate Buy” by Brokerages - Defense World
Ionis Pharmaceuticals (NASDAQ:IONS) versus Akero Therapeutics (NASDAQ:AKRO) Financial Contrast - Defense World
Transcript : Ionis Pharmaceuticals, Inc.Shareholder/Analyst Call - marketscreener.com
10 Promising Biotech Stocks to Invest in (June 2025) - Securities.io
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Grows Stock Position in Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) - Defense World
Why Is Ionis Pharmaceuticals (IONS) Up 5.5% Since Last Earnings Report? - Yahoo Finance
We Discuss Why Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) CEO Compensation May Be Closely Reviewed - simplywall.st
Transthyretin Amyloid Cardiomyopathy Treatment Market Deep Research ReportPfizer, Ionis Pharmaceuticals - openPR.com
Type 2 Diabetes Pipeline 2025: Therapies Under Investigation, - openPR.com
Ionis Pharmaceuticals’ SWOT analysis: RNA therapeutics firm faces pivotal year for stock - Investing.com
Angioedema Treatment Market Insights and Forecast from 2025 - openPR.com
Hereditary Angioedema Drugs Market 2034: EMA, PDMA, FDA - openPR.com
D. E. Shaw & Co. Inc. Reduces Stock Holdings in Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) - Defense World
Ionis’ olezarsen shows new promise with strong Phase III results - The Pharma Letter
December 2027 Options Now Available For Ionis Pharmaceuticals (IONS) - Nasdaq
Ionis reports success in olezarsen trial for high triglycerides - Yahoo
Treatment-Resistant Hypertension Market: Epidemiology, - openPR.com
Ionis Pharmaceuticals (NASDAQ:IONS) Earns Buy Rating from HC Wainwright - Defense World
Ionis' Tryngolza Cuts Triglyceride Levels in Late-Stage Study - MSN
Hereditary Angioedema Market Set to Grow Substantially Through - openPR.com
Analysts Offer Insights on Healthcare Companies: Strata Skin Sciences (SSKN), Ionis Pharmaceuticals (IONS) and Maze Therapeutics, Inc. (MAZE) - The Globe and Mail
Transcript : Ionis Pharmaceuticals, Inc. Presents at RBC Capital Markets Global Healthcare Conference 2025, May-21-2025 08 - marketscreener.com
Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Shares Purchased by Janus Henderson Group PLC - Defense World
Ionis reports positive data from study of olezarsen for hypertriglyceridemia - Clinical Trials Arena
Ionis Pharmaceuticals Inc Stock (IONS) Financials Data
Revenue
Net Income
Cash Flow
EPS
Ionis Pharmaceuticals Inc Stock (IONS) Insider Trading
| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total |
|---|---|---|---|---|---|---|---|
| Birchler Brian | EVP, Corp and Development Ops |
Apr 15 '25 |
Option Exercise |
0.00 |
1,875 |
0 |
57,340 |
| Birchler Brian | EVP, Corp and Development Ops |
Apr 16 '25 |
Sale |
28.37 |
680 |
19,292 |
56,660 |
| Jenne Kyle | EVP, Chf GL Pdt Str Ofcr |
Apr 15 '25 |
Option Exercise |
0.00 |
12,226 |
0 |
14,215 |
| Jenne Kyle | EVP, Chf GL Pdt Str Ofcr |
Apr 16 '25 |
Sale |
28.36 |
3,016 |
85,534 |
11,199 |
| Baroldi Joseph | EVP, Chief Business Officer |
Apr 15 '25 |
Option Exercise |
0.00 |
10,837 |
0 |
35,854 |
| Baroldi Joseph | EVP, Chief Business Officer |
Apr 16 '25 |
Sale |
28.40 |
3,928 |
111,555 |
31,926 |
0.61%
0.56%
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