71.50
price down icon0.20%   -0.14
after-market After Hours: 72.93 1.43 +2.00%
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Ionis Pharmaceuticals Inc stock is traded at $71.50, with a volume of 1.47M. It is down -0.20% in the last 24 hours and up +16.53% over the past month. Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.
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Previous Close:
$71.64
Open:
$71.23
24h Volume:
1.47M
Relative Volume:
0.60
Market Cap:
$11.40B
Revenue:
$705.14M
Net Income/Loss:
$-453.90M
P/E Ratio:
-23.52
EPS:
-3.04
Net Cash Flow:
$-551.29M
1W Performance:
-1.23%
1M Performance:
+16.53%
6M Performance:
+146.30%
1Y Performance:
+84.85%
1-Day Range:
Value
$70.60
$71.98
1-Week Range:
Value
$70.47
$74.42
52-Week Range:
Value
$23.95
$74.42

Ionis Pharmaceuticals Inc Stock (IONS) Company Profile

Name
Name
Ionis Pharmaceuticals Inc
Name
Phone
(760) 931-9200
Name
Address
2855 GAZELLE COURT, CARLSBAD, CA
Name
Employee
927
Name
Twitter
@ionispharma
Name
Next Earnings Date
2024-11-06
Name
Latest SEC Filings
Name
IONS's Discussions on Twitter

Compare IONS with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
IONS
Ionis Pharmaceuticals Inc
71.50 11.42B 705.14M -453.90M -551.29M -3.04
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
426.44 109.29B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
464.90 62.13B 2.46B -319.09M -52.09M -2.4669
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
584.74 61.40B 14.21B 4.46B 3.56B 39.69
Biotechnology icon
ARGX
Argen X Se Adr
814.17 51.39B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ONC
Beone Medicines Ltd Adr
313.54 34.68B 4.56B -176.77M 225.30M -1.7177

Ionis Pharmaceuticals Inc Stock (IONS) Upgrades & Downgrades

Date Action Analyst Rating Change
Oct-08-25 Upgrade JP Morgan Neutral → Overweight
Sep-26-25 Upgrade Goldman Sell → Neutral
Sep-03-25 Upgrade BMO Capital Markets Market Perform → Outperform
Jul-31-25 Upgrade Morgan Stanley Equal-Weight → Overweight
Jul-01-25 Upgrade Barclays Equal Weight → Overweight
Apr-07-25 Initiated H.C. Wainwright Buy
Mar-31-25 Initiated Redburn Atlantic Neutral
Aug-02-24 Downgrade BMO Capital Markets Outperform → Market Perform
Jul-24-24 Upgrade Leerink Partners Market Perform → Outperform
Jul-16-24 Resumed Jefferies Buy
Jun-14-24 Upgrade Bernstein Underperform → Mkt Perform
Apr-10-24 Upgrade Wolfe Research Peer Perform → Outperform
Jan-02-24 Upgrade BofA Securities Neutral → Buy
Oct-23-23 Upgrade BofA Securities Underperform → Neutral
Sep-29-23 Initiated Raymond James Strong Buy
Jul-31-23 Upgrade Citigroup Neutral → Buy
Jun-07-23 Resumed Piper Sandler Overweight
May-04-23 Upgrade Citigroup Sell → Neutral
Mar-21-23 Initiated Bernstein Underperform
Dec-21-22 Downgrade Morgan Stanley Overweight → Equal-Weight
Sep-09-22 Resumed Morgan Stanley Overweight
Jul-18-22 Resumed Oppenheimer Outperform
Mar-31-22 Resumed Piper Sandler Overweight
Mar-01-22 Initiated Citigroup Sell
Mar-01-22 Initiated Guggenheim Buy
Feb-01-22 Downgrade BofA Securities Buy → Underperform
Dec-14-21 Upgrade William Blair Mkt Perform → Outperform
May-07-21 Upgrade UBS Sell → Neutral
Mar-01-21 Upgrade Barclays Underweight → Equal Weight
Dec-16-20 Initiated UBS Sell
Dec-15-20 Upgrade Cowen Market Perform → Outperform
Sep-14-20 Resumed JP Morgan Neutral
Sep-02-20 Initiated The Benchmark Company Hold
Jun-01-20 Resumed Oppenheimer Outperform
May-13-20 Initiated RBC Capital Mkts Outperform
Mar-05-20 Initiated Citigroup Buy
Dec-13-19 Initiated Oppenheimer Outperform
Nov-13-19 Initiated BofA/Merrill Buy
Nov-07-19 Downgrade Morgan Stanley Equal-Weight → Underweight
Sep-10-19 Upgrade Bernstein Mkt Perform → Outperform
Aug-08-18 Reiterated Stifel Hold
Aug-07-18 Reiterated Stifel Hold
May-08-18 Downgrade Evercore ISI Outperform → In-line
Oct-06-17 Resumed Goldman Sell
Aug-17-17 Initiated Evercore ISI Outperform
Aug-09-17 Reiterated Stifel Hold
Mar-10-17 Downgrade Goldman Neutral → Sell
Dec-28-16 Reiterated BMO Capital Markets Outperform
Dec-27-16 Reiterated Leerink Partners Mkt Perform
View All

Ionis Pharmaceuticals Inc Stock (IONS) Latest News

pulisher
10:00 AM

Ionis Pharmaceuticals (IONS) Expected to Beat Earnings Estimates: Can the Stock Move Higher? - Yahoo Finance

10:00 AM
pulisher
12:40 PM

What is the fair value estimate for Ionis Pharmaceuticals Inc. (ISI) stock in 20252025 Fundamental Recap & High Accuracy Investment Signals - newser.com

12:40 PM
pulisher
Oct 21, 2025

Published on: 2025-10-21 21:59:51 - newser.com

Oct 21, 2025
pulisher
Oct 21, 2025

Can Ionis Pharmaceuticals Inc. (ISI) stock sustain revenue momentumBond Market & Real-Time Stock Entry Alerts - newser.com

Oct 21, 2025
pulisher
Oct 21, 2025

Sector ETF performance correlation with Ionis Pharmaceuticals Inc.Portfolio Risk Summary & Technical Pattern Based Buy Signals - newser.com

Oct 21, 2025
pulisher
Oct 21, 2025

Ionis CEO Brett P. Monia receives 2025 Lifetime Achievement Award from the Oligonucleotide Therapeutics Society - Business Wire

Oct 21, 2025
pulisher
Oct 21, 2025

Is Ionis Pharmaceuticals Inc. stock poised for growth2025 Price Momentum & Weekly Hot Stock Watchlists - newser.com

Oct 21, 2025
pulisher
Oct 21, 2025

Published on: 2025-10-21 01:16:00 - newser.com

Oct 21, 2025
pulisher
Oct 20, 2025

Ionis Pharmaceuticals Inc. stock trend outlook and recovery pathJuly 2025 Sentiment & Scalable Portfolio Growth Ideas - newser.com

Oct 20, 2025
pulisher
Oct 20, 2025

Can Ionis Pharmaceuticals Inc. stock resist market sell offsNew Guidance & Community Trade Idea Sharing - newser.com

Oct 20, 2025
pulisher
Oct 20, 2025

Capricorn Buys New Stake in Ionis Pharmaceuticals (IONS) With 163,000 Shares - The Motley Fool

Oct 20, 2025
pulisher
Oct 20, 2025

News impact scoring models applied to Ionis Pharmaceuticals Inc.July 2025 Sentiment & Accurate Technical Buy Alerts - newser.com

Oct 20, 2025
pulisher
Oct 20, 2025

Is Ionis Pharmaceuticals Inc. (ISI) stock resilient in recession scenariosIPO Watch & Verified Technical Signals - nchmf.gov.vn

Oct 20, 2025
pulisher
Oct 20, 2025

Can you recover from losses in Ionis Pharmaceuticals Inc.Portfolio Return Report & Smart Allocation Stock Tips - newser.com

Oct 20, 2025
pulisher
Oct 20, 2025

Is Ionis Pharmaceuticals Inc. stock ready for breakoutJuly 2025 Outlook & Consistent Profit Alerts - newser.com

Oct 20, 2025
pulisher
Oct 20, 2025

Will Ionis Pharmaceuticals Inc. stock deliver better than expected guidanceTrade Ideas & Verified Technical Signals - newser.com

Oct 20, 2025
pulisher
Oct 19, 2025

Is Ionis Pharmaceuticals Inc. building a consolidation baseEarnings Performance Report & Weekly High Return Stock Forecasts - newser.com

Oct 19, 2025
pulisher
Oct 19, 2025

Why ETFs are accumulating Ionis Pharmaceuticals Inc. (ISI) stockGold Moves & Safe Capital Allocation Plans - newser.com

Oct 19, 2025
pulisher
Oct 18, 2025

What recovery options are there for Ionis Pharmaceuticals Inc.July 2025 Setups & Detailed Earnings Play Strategies - newser.com

Oct 18, 2025
pulisher
Oct 18, 2025

Should Ionis Pharmaceuticals' (IONS) Raised Revenue Guidance and Strong Q2 Results Prompt Investor Action? - Sahm

Oct 18, 2025
pulisher
Oct 18, 2025

Can Ionis Pharmaceuticals Inc. stock weather global recessionTrade Exit Summary & Technical Entry and Exit Tips - nchmf.gov.vn

Oct 18, 2025
pulisher
Oct 18, 2025

Layoff Watch: Can Ionis Pharmaceuticals Inc. stock weather global recessionJuly 2025 PostEarnings & Stepwise Trade Signal Guides - nchmf.gov.vn

Oct 18, 2025
pulisher
Oct 17, 2025

Will Ionis Pharmaceuticals Inc. stock sustain high P E ratiosRecession Risk & Advanced Swing Trade Entry Plans - nchmf.gov.vn

Oct 17, 2025
pulisher
Oct 17, 2025

Bear Alert: Is Ionis Pharmaceuticals Inc. stock a top pick in earnings seasonQuarterly Trade Report & Smart Money Movement Tracker - nchmf.gov.vn

Oct 17, 2025
pulisher
Oct 17, 2025

Hedge Fund and Insider Trading News: Scott Bessent, Paul Tudor Jones, Crispin Odey, Ken Griffin, Millennium Management, Ionis Pharmaceutical Inc (IONS), Chicago Atlantic Real Estate Finance Inc (REFI), and More - Insider Monkey

Oct 17, 2025
pulisher
Oct 17, 2025

CapEx per share of Ionis Pharmaceuticals, Inc. – DUS:ISI - TradingView

Oct 17, 2025
pulisher
Oct 17, 2025

Ionis Pharmaceuticals Insider Sold Shares Worth $1,723,987, According to a Recent SEC Filing - MarketScreener

Oct 17, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals director Parshall sells $358,721 in stock By Investing.com - Investing.com Australia

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals EVP Birchler sells $1.72m in shares By Investing.com - Investing.com Australia

Oct 16, 2025
pulisher
Oct 16, 2025

Insider Sell Alert: B Parshall Sells 5,000 Shares of Ionis Pharm - GuruFocus

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharma EVP Devers sells shares worth $530,636 By Investing.com - Investing.com Canada

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals EVP research, Eric Swayze, sells $3901 in IONS stock - Investing.com Nigeria

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals EVP Birchler sells $1.72m in shares - Investing.com

Oct 16, 2025
pulisher
Oct 16, 2025

Morgan Stanley Raises Price Target for Ionis Pharmaceuticals (IO - GuruFocus

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals Hits New 52-Week High of $72.15 - Markets Mojo

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis Pharmaceuticals Hits New 52-Week High of $73.92 - Markets Mojo

Oct 16, 2025
pulisher
Oct 16, 2025

Morgan Stanley Raises Price Target on Ionis Pharmaceuticals to $90 From $86, Keeps Overweight Rating - MarketScreener

Oct 16, 2025
pulisher
Oct 16, 2025

Ionis to hold third quarter 2025 financial results webcast - FinancialContent

Oct 16, 2025
pulisher
Oct 16, 2025

Lobbying Update: $140,000 of IONIS PHARMACEUTICALS INC. lobbying was just disclosed - Quiver Quantitative

Oct 16, 2025

Ionis Pharmaceuticals Inc Stock (IONS) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$36.84
price down icon 1.71%
$88.06
price up icon 0.87%
$29.92
price down icon 0.70%
$106.23
price down icon 0.62%
$160.40
price down icon 2.97%
biotechnology ONC
$313.54
price down icon 0.70%
Cap:     |  Volume (24h):