55.83
price up icon3.00%   1.625
after-market After Hours: 55.20 -0.63 -1.13%
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Spruce Biosciences Inc stock is traded at $55.83, with a volume of 14,857. It is up +3.00% in the last 24 hours and down -33.13% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$54.20
Open:
$54.12
24h Volume:
14,857
Relative Volume:
0.27
Market Cap:
$59.76M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-59.39
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
-4.11%
1M Performance:
-33.13%
6M Performance:
-89.73%
1Y Performance:
-90.34%
1-Day Range:
Value
$53.00
$55.83
1-Week Range:
Value
$51.78
$62.94
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB vs VRTX, REGN, ARGX, ALNY, ONC

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
55.83 58.02M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
474.27 123.47B 12.07B 3.95B 3.19B 15.33
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
766.66 83.60B 14.34B 4.50B 3.77B 41.56
Biotechnology icon
ARGX
Argen X Se Adr
748.72 46.83B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
318.65 43.11B 3.71B 313.75M 465.38M 2.2571
Biotechnology icon
ONC
Beone Medicines Ltd Adr
297.04 34.79B 4.98B 69.60M 525.67M 0.5198

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-23-25 Initiated Oppenheimer Outperform
Dec-03-25 Upgrade Leerink Partners Market Perform → Outperform
Oct-28-25 Upgrade Citizens JMP Mkt Perform → Mkt Outperform
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

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Mar 03, 2026

SPRB Earning Date, Earning Analysis and Earning Prediction - Intellectia AI

Mar 03, 2026
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Mar 03, 2026

Spruce Biosciences (SPRB) Gains FDA Support for Accelerated Approval Pathway - Finviz

Mar 03, 2026
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Mar 03, 2026

SPRB Financials: Income Statement, Balance Sheet & Cash Flow - Stock Titan

Mar 03, 2026
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Mar 02, 2026

Spruce Biosciences to Present at Upcoming Investor Conferences in March - Investing News Network

Mar 02, 2026
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Mar 02, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) Given Average Rating of "Hold" by Analysts - MarketBeat

Mar 02, 2026
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Mar 01, 2026

Spruce Biosciences Touts MPS IIIB Data, Targets Q4 BLA Submission at Oppenheimer Conference - MarketBeat

Mar 01, 2026
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Feb 27, 2026

Spruce Biosciences Inc. (SPRB) Stock Price | Live Quotes & Charts | NASDAQ - StocksToTrade

Feb 27, 2026
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Feb 26, 2026

Total debt per share of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView

Feb 26, 2026
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Feb 24, 2026

Carlyle Group Inc. Expands Stake in Spruce Biosciences Inc. - GuruFocus

Feb 24, 2026
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Feb 24, 2026

Millennium group (SPR B) joint Schedule 13G shows ~103K shares (~9.6%) - Stock Titan

Feb 24, 2026
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Feb 23, 2026

HC Wainwright Has Positive Outlook for SPRB FY2025 Earnings - MarketBeat

Feb 23, 2026
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Feb 21, 2026

SPRB Stock Drops After Company Pushes Back Application Submission Timeline For Experimental Sanfilippo Syndrome Therapy - Stocktwits

Feb 21, 2026
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Feb 19, 2026

Regulatory De-Risking and Extended Runway Underpin Maintained Buy Rating on Spruce Biosciences - TipRanks

Feb 19, 2026
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Feb 19, 2026

SPRB Analyst Rating Update: HC Wainwright Lowers Price Target | - GuruFocus

Feb 19, 2026
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Feb 19, 2026

Carlyle Group Inc. Takes Position in Spruce Biosciences, Inc. $SPRB - MarketBeat

Feb 19, 2026
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Feb 18, 2026

Spruce Biosciences Stock Falls 5% Despite Positive Outcomes From Two Recent Type B Meetings With FDA - Nasdaq

Feb 18, 2026
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Feb 18, 2026

Spruce Biosciences Gains After Positive FDA Type B Meetings On TA-ERT - Nasdaq

Feb 18, 2026
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Feb 18, 2026

Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB) - Business Wire

Feb 18, 2026
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Feb 18, 2026

Spruce Biosciences, Inc. shares recorded a significant increase, rising by 8.16% in a single day. - Bitget

Feb 18, 2026
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Feb 17, 2026

Spruce Biosciences to Participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference - Investing News Network

Feb 17, 2026
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Feb 17, 2026

Biotech working on neurological drugs joins Oppenheimer stage - Stock Titan

Feb 17, 2026
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Feb 17, 2026

Spruce Biosciences recently announced that its candidate drug TA-ERT for Sanfilippo syndrome type B (also known as MPS IIIB) received positive feedback during a Type B meeting with the U.S. Food and Drug Administration (FDA). - Bitget

Feb 17, 2026
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Feb 14, 2026

SPRB PE Ratio & Valuation, Is SPRB Overvalued - Intellectia AI

Feb 14, 2026
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Feb 13, 2026

SPRB Should I Buy - Intellectia AI

Feb 13, 2026
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Feb 06, 2026

Spruce Biosciences: TA-ERT’s Promising Long-Term Data and Priority Review Voucher Upside Underpin Reiterated Buy and $220 Target - TipRanks

Feb 06, 2026
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Feb 05, 2026

Experimental enzyme therapy stabilizes skills for 6 years in fatal disorder - Stock Titan

Feb 05, 2026
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Feb 05, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) Receives Consensus Rating of "Hold" from Brokerages - MarketBeat

Feb 05, 2026
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Feb 04, 2026

Spruce Biosciences Adds Regulatory and Clinical Development Expertise to Leadership Team - BioSpace

Feb 04, 2026
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Feb 03, 2026

Spruce Biosciences Makes Two SVP Appointments - Contract Pharma

Feb 03, 2026
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Feb 03, 2026

Spruce Biosciences (NASDAQ:SPRB) Shares Up 0.6%Time to Buy? - MarketBeat

Feb 03, 2026
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Jan 29, 2026

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium™ - BioSpace

Jan 29, 2026
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Jan 28, 2026

Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium - Investing News Network

Jan 28, 2026
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Jan 21, 2026

Harbour BioMed Exercises Warrant to Acquire 3.8% of Spruce Biosciences Inc. - intellectia.ai

Jan 21, 2026
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Jan 21, 2026

Big-Pharma Partner Harbour BioMed Boosts Stake In Spruce Biosciences - Benzinga

Jan 21, 2026
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Jan 20, 2026

Harbour BioMed Acquires Stake in U.S. Partner Spruce Biosciences, Signaling Strategic Shift in Chinese Biotech - IndexBox

Jan 20, 2026
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Jan 20, 2026

Harbour BioMed Acquires 3.8% of Spruce Biosciences, Enhancing Strategic Partnership - Intellectia AI

Jan 20, 2026
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Jan 19, 2026

Harbour BioMed Expands Stake in Spruce Biosciences (SPRB) - GuruFocus

Jan 19, 2026
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Jan 19, 2026

Harbour BioMed Exercises Agreement to Buy Spruce Biosciences Common Stock - Contract Pharma

Jan 19, 2026
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Jan 19, 2026

Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences - Intellectia AI

Jan 19, 2026
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Jan 18, 2026

Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences (SPRB) - Intellectia AI

Jan 18, 2026
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Jan 18, 2026

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deep - GuruFocus

Jan 18, 2026
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Jan 18, 2026

Harbour BioMed Exercises Warrant To Acquire Stake In Spruce Biosciences - Nasdaq

Jan 18, 2026
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Jan 18, 2026

HBM Holdings Deepens Ties With Spruce Biosciences via Warrant Exercise - TipRanks

Jan 18, 2026
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Jan 18, 2026

Harbour BioMed buys into Spruce to back new hormone disorder drug - Stock Titan

Jan 18, 2026
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Jan 18, 2026

Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration - Barchart.com

Jan 18, 2026
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Jan 18, 2026

Harbour BioMed takes stake in Spruce Biosciences - MSN

Jan 18, 2026
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Jan 14, 2026

Spruce Biosciences (SPRB) Price Target Increased by 10.02% to 235.11 - Nasdaq

Jan 14, 2026
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Jan 11, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) Receives Average Rating of "Moderate Buy" from Analysts - MarketBeat

Jan 11, 2026
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Jan 08, 2026

Spruce Biosciences Secures Up to $50 Million in Growth Capital from Avenue Capital - BioSpace

Jan 08, 2026
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Jan 08, 2026

Spruce Biosciences secures up to $50 million in growth capital from Avenue Capital - marketscreener.com

Jan 08, 2026
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Jan 08, 2026

Spruce Biosciences Signs Multiple Financing Agreements - TradingView — Track All Markets

Jan 08, 2026

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$49.83
price down icon 5.71%
$27.85
price down icon 0.89%
$47.48
price up icon 0.02%
$100.76
price down icon 6.25%
$147.00
price up icon 0.46%
biotechnology ONC
$297.04
price down icon 5.51%
Cap:     |  Volume (24h):