41.99

2.53% -1.09

After Hours: 41.98 -0.01 -0.02%

Spruce Biosciences Inc (SPRB)

Overview News Price History Financials Discussions Forecast

Spruce Biosciences Inc stock is traded at $41.99, with a volume of 67,715. It is down -2.53% in the last 24 hours and down -23.81% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.

Previous Close:

$43.08

Open:

$42.64

24h Volume:

67,715

Relative Volume:

1.01

Market Cap:

$115.57M

Revenue:

$697.00K

Net Income/Loss:

$-37.19M

P/E Ratio:

-1.1139

EPS:

-37.6952

Net Cash Flow:

$-29.34M

1W Performance:

-5.64%

1M Performance:

-23.81%

6M Performance:

-50.15%

1Y Performance:

-92.27%

1-Day Range:

$41.98

$45.51

1-Week Range:

$41.53

$46.27

52-Week Range:

$7.26

$240.00

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name

Spruce Biosciences Inc

Sector

Healthcare (1074)

Industry

Biotechnology (599)

Phone

(415) 655-4168

Address

611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO

Employee

Twitter

Next Earnings Date

2026-08-13

Latest SEC Filings

SPRB's Discussions on Twitter

Compare SPRB vs VRTX, REGN, ARGX, RVMD, ALNY

Stocks	Price	Market Cap	Revenue	Net Income	Cash Flow	EPS
SPRB Spruce Biosciences Inc	41.99	118.57M	697.00K	-37.19M	-29.34M	-37.70
VRTX Vertex Pharmaceuticals Inc	479.00	121.16B	12.34B	4.34B	3.71B	16.87
REGN Regeneron Pharmaceuticals Inc	667.17	68.78B	14.92B	4.42B	3.79B	41.04
ARGX Argen X Se Adr	888.82	57.44B	4.16B	1.29B	734.26M	19.58
RVMD Revolution Medicines Inc	188.07	40.23B	742.00K	-1.37B	-1.07B	-7.0731
ALNY Alnylam Pharmaceuticals Inc	278.40	36.28B	4.29B	577.22M	641.34M	4.2086

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date	Action	Analyst	Rating Change
Apr-27-26	Initiated	Craig Hallum	Buy
Dec-23-25	Initiated	Oppenheimer	Outperform
Dec-03-25	Upgrade	Leerink Partners	Market Perform → Outperform
Oct-28-25	Upgrade	Citizens JMP	Mkt Perform → Mkt Outperform
Dec-11-24	Downgrade	JMP Securities	Mkt Outperform → Mkt Perform
Dec-11-24	Downgrade	Oppenheimer	Outperform → Perform
Mar-14-24	Downgrade	Guggenheim	Buy → Neutral
Mar-14-24	Downgrade	H.C. Wainwright	Buy → Neutral
Mar-14-24	Downgrade	Ladenburg Thalmann	Buy → Neutral
Mar-14-24	Downgrade	Leerink Partners	Outperform → Market Perform
Mar-14-24	Downgrade	RBC Capital Mkts	Outperform → Sector Perform
Feb-21-24	Initiated	Guggenheim	Buy
Dec-17-21	Initiated	Oppenheimer	Outperform
Dec-10-21	Initiated	The Benchmark Company	Speculative Buy
Nov-16-21	Downgrade	SVB Leerink	Outperform → Mkt Perform
Jul-19-21	Initiated	H.C. Wainwright	Buy
Apr-26-21	Resumed	Credit Suisse	Outperform
Nov-03-20	Initiated	Cowen	Outperform
Nov-03-20	Initiated	Credit Suisse	Outperform
Nov-03-20	Initiated	RBC Capital Mkts	Outperform
Nov-03-20	Initiated	SVB Leerink	Outperform

View All

Spruce Biosciences Inc Stock (SPRB) Latest News

04:05 AM

Spruce Biosciences (SPRB) gains 9.1% shareholder group led by AIGH - Stock Titan

04:05 AM

03:02 AM

Spruce Biosciences Welcomes Adrian Quartel as Chief Medical Officer - Contract Pharma

03:02 AM

11:00 AM

Spruce Biosciences, Inc. Files Form 8-K: Company Details, Nasdaq Listing, and Corporate Information (July 2026) - Minichart

11:00 AM

10:40 AM

Spruce Biosciences Appoints Adrian Quartel, M.D., FFPM, as Chief Medical Officer - Investing News Network

10:40 AM

08:47 AM

Spruce Biosciences appoints Adrian Quartel as chief medical officer - Investing.com

08:47 AM

08:05 AM

Spruce Biosciences (NASDAQ: SPRB) names Adrian Quartel as chief medical officer - Stock Titan

08:05 AM

Jul 26, 2026

SPRB|Spruce Biosciences Inc|Price:43.080|Chg%:-1.910 - TradingKey

Jul 26, 2026

Jul 25, 2026