Get the Stockscreener App
50.77
2.08%
-1.08
After Hours:
50.77
Spruce Biosciences Inc stock is traded at $50.77, with a volume of 77,032.
It is down -2.08% in the last 24 hours and up +0.67% over the past month.
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
See More
Previous Close:
$51.85
Open:
$52
24h Volume:
77,032
Relative Volume:
1.02
Market Cap:
$139.73M
Revenue:
$697.00K
Net Income/Loss:
$-37.19M
P/E Ratio:
-1.3469
EPS:
-37.6952
Net Cash Flow:
$-29.34M
1W Performance:
-5.98%
1M Performance:
+0.67%
6M Performance:
-34.99%
1Y Performance:
-90.34%
1-Day Range:
$49.70
$52.56
1-Week Range:
$49.70
$55.21
52-Week Range:
$7.26
$543.38
Spruce Biosciences Inc Stock (SPRB) Company Profile
Name
Spruce Biosciences Inc
Sector
Industry
Phone
(415) 655-4168
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Compare SPRB vs VRTX, REGN, ARGX, ALNY, RVMD
| Stocks | Price | Market Cap | Revenue | Net Income | Cash Flow | EPS |
|---|---|---|---|---|---|---|
SPRB
Spruce Biosciences Inc
|
50.77 | 142.71M | 697.00K | -37.19M | -29.34M | -37.70 |
VRTX
Vertex Pharmaceuticals Inc
|
522.25 | 134.41B | 12.34B | 4.34B | 3.71B | 16.87 |
REGN
Regeneron Pharmaceuticals Inc
|
676.23 | 68.13B | 14.92B | 4.42B | 3.79B | 41.04 |
ARGX
Argen X Se Adr
|
919.94 | 57.01B | 4.16B | 1.29B | 734.26M | 19.58 |
ALNY
Alnylam Pharmaceuticals Inc
|
321.59 | 41.79B | 4.29B | 577.22M | 641.34M | 4.2086 |
RVMD
Revolution Medicines Inc
|
190.46 | 40.39B | 742.00K | -1.37B | -1.07B | -7.0731 |
Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades
| Date | Action | Analyst | Rating Change |
|---|---|---|---|
| Apr-27-26 | Initiated | Craig Hallum | Buy |
| Dec-23-25 | Initiated | Oppenheimer | Outperform |
| Dec-03-25 | Upgrade | Leerink Partners | Market Perform → Outperform |
| Oct-28-25 | Upgrade | Citizens JMP | Mkt Perform → Mkt Outperform |
| Dec-11-24 | Downgrade | JMP Securities | Mkt Outperform → Mkt Perform |
| Dec-11-24 | Downgrade | Oppenheimer | Outperform → Perform |
| Mar-14-24 | Downgrade | Guggenheim | Buy → Neutral |
| Mar-14-24 | Downgrade | H.C. Wainwright | Buy → Neutral |
| Mar-14-24 | Downgrade | Ladenburg Thalmann | Buy → Neutral |
| Mar-14-24 | Downgrade | Leerink Partners | Outperform → Market Perform |
| Mar-14-24 | Downgrade | RBC Capital Mkts | Outperform → Sector Perform |
| Feb-21-24 | Initiated | Guggenheim | Buy |
| Dec-17-21 | Initiated | Oppenheimer | Outperform |
| Dec-10-21 | Initiated | The Benchmark Company | Speculative Buy |
| Nov-16-21 | Downgrade | SVB Leerink | Outperform → Mkt Perform |
| Jul-19-21 | Initiated | H.C. Wainwright | Buy |
| Apr-26-21 | Resumed | Credit Suisse | Outperform |
| Nov-03-20 | Initiated | Cowen | Outperform |
| Nov-03-20 | Initiated | Credit Suisse | Outperform |
| Nov-03-20 | Initiated | RBC Capital Mkts | Outperform |
| Nov-03-20 | Initiated | SVB Leerink | Outperform |
View All
Spruce Biosciences Inc Stock (SPRB) Latest News
Price to book forward of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView
SPRB Stock Drops After Company Pushes Back Application Submission Timeline For Experimental Sanfilippo Syndrome Therapy - Stocktwits
Spruce Biosciences (SPRB) Joins Russell 3000 Index - GuruFocus
Spruce Biosciences Joins the Russell 3000® Index - BioSpace
Spruce Biosciences, Inc.(NasdaqCM:SPRB) added to Russell Small Cap Comp Growth Benchmark - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell 2500 Growth Benchmark - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell 2000 Index - marketscreener.com
Spruce Biosciences added to Russell 3000 index By Investing.com - Investing.com South Africa
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell 2000 Value Benchmark - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM:SPRB) added to Russell Microcap Value Benchmark Index - marketscreener.com
Spruce Biosciences added to Russell 3000 index - Investing.com
Spruce Biosciences, Inc.(NasdaqCM:SPRB) added to Russell Microcap Growth Benchmark Index - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell 3000E Growth Benchmark - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell Microcap Index - marketscreener.com
Spruce Biosciences, Inc.(NasdaqCM: SPRB) added to Russell 2500 Value Benchmark - marketscreener.com
Price to sales forward of Spruce Biosciences, Inc. – BOATS:SPRB - TradingView
Spruce Biosciences, Inc.(NasdaqCM:SPRB) added to Russell Small Cap Comp Value Benchmark - marketscreener.com
Spruce Biosciences Q1 2026 Earnings: Narrower-than-Expected Loss Drives Stock RallyEarnings Beat Streak - dars.gov.et
Enterprise value to EBIT forward of Spruce Biosciences, Inc. – BOATS:SPRB - TradingView
Enterprise value to EBITDA forward of Spruce Biosciences, Inc. – BOATS:SPRB - TradingView
Price to earnings forward of Spruce Biosciences, Inc. – NASDAQ:SPRB - TradingView
Spruce Biosciences, Inc. Actuals & Estimates (NASDAQ:SPRB) - TradingView
SPRB Forecast — Price Target — Prediction for 2027 - TradingView
Spruce Biosciences Inc (SPRB) Financial Health: Profitability & Balance Sheet Analysis - TradingKey
Spruce Biosciences names Agnieszka Jurecka as VP medical affairs - Investing.com UK
Spruce Biosciences names Agnieszka Jurecka as VP medical affairs By Investing.com - Investing.com South Africa
Spruce Biosciences Signals Commercial Shift with Key Hire for Rare Disease Drug - BriefGlance
Spruce Biosciences Appoints Agnieszka Jurecka, M.D., Ph.D., MPH, as Vice President, Medical Affairs - Business Wire
Spruce Biosciences Inc (SPRB) Shareholder Structure: Major Shareholders & Institutional Holdings - TradingKey
Spruce Biosciences Inc (SPRB) Dividends & Stock Splits: Historical Payouts and Event Timeline - TradingKey
Spruce Biosciences Inc (SPRB) Revenue Breakdown: Business Segments, Regional Revenue & Profit Contribution - TradingKey
Spruce Biosciences Inc (SPRB) Earnings Forecast: Future EPS & Revenue Growth Estimates - TradingKey
Spruce Biosciences Inc (SPRB) Technical Analysis: Support, Resistance, Indicators & Moving Averages - TradingKey
Spruce Biosciences Inc (SPRB) Valuation: PE, PB & Fair Value Analysis - TradingKey
Spruce Biosciences Inc (SPRB) Risk Assessment: Volatility, Financial Risk & Investment Risk - TradingKey
Spruce Biosciences Inc (SPRB) Institutional Confidence - TradingKey
SPRB Initiates Coverage by Guggenheim -- Price Target Announced at $123 - GuruFocus
Guggenheim Initiates Spruce Biosciences(SPRB.US) With Buy Rating, Announces Target Price $123 - Moomoo
BBIO Welcomes New Leadership in Marketing and Finance - GuruFocus
Spruce Biosciences Appoints Eric Jordan as Vice President, Marketing and Tina Gullotta as Vice President, Finance and Corporate Controller - Investing News Network
Spruce Biosciences names two executives ahead of potential FDA decision By Investing.com - Investing.com Nigeria
Spruce Biosciences names two executives ahead of potential FDA decision - Investing.com
Spruce Biosciences Appoints Eric Jordan and Tina Gullotta to Leadership Roles Ahead of Potential TA-ERT Launch - citybiz
Spruce Biosciences Builds Its Commercial War Chest for a Rare Disease Bet - BriefGlance
SPRB Q1 2026 Earnings: Narrower-than-Expected Loss Drives Positive SentimentEarnings Cycle Outlook - newsline.com
SPRB News | SPRUCE BIOSCIENCES INC (NASDAQ:SPRB) - ChartMill
SPRB Initiated Coverage by Jones Trading -- Rating Set to Buy - GuruFocus
Jones Trading initiates Spruce Biosciences stock with buy rating on therapy potential By Investing.com - Investing.com Australia
Spruce Biosciences (SPRB) Reports Promising Long-Term Results fo - GuruFocus
Jones Trading initiates Spruce Biosciences stock with buy rating on therapy potential - Investing.com UK
Spruce Biosciences Announces Long-Term Tralesinidase Alfa Enzyme Replacement Therapy Data in Sanfilippo Syndrome Type B Presented at the 18th International MPS Symposium - Investing News Network
Spruce Biosciences Inc Stock (SPRB) Financials Data
Revenue
Net Income
Cash Flow
EPS
Spruce Biosciences Inc Stock (SPRB) Insider Trading
| Insider Trading | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total |
|---|---|---|---|---|---|---|---|
| Gharib Samir M. | PRESIDENT AND CFO |
Dec 15 '25 |
Option Exercise |
0.00 |
1,009 |
0 |
8,447 |
| Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER |
Dec 15 '25 |
Option Exercise |
0.00 |
2,676 |
0 |
14,922 |
| Gharib Samir M. | PRESIDENT AND CFO |
Dec 11 '25 |
Option Exercise |
0.00 |
1,900 |
0 |
8,296 |
| Gharib Samir M. | PRESIDENT AND CFO |
Dec 10 '25 |
Option Exercise |
0.00 |
514 |
0 |
6,580 |
| Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER |
Dec 11 '25 |
Option Exercise |
0.00 |
4,950 |
0 |
15,192 |
| Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER |
Dec 10 '25 |
Option Exercise |
0.00 |
1,196 |
0 |
10,670 |
| Gharib Samir M. | PRESIDENT AND CFO |
Oct 20 '25 |
Option Exercise |
0.00 |
2,053 |
0 |
6,727 |
| Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER |
Oct 20 '25 |
Option Exercise |
0.00 |
4,784 |
0 |
11,013 |
| Parkman Healthcare Partners LL | 10% Owner |
Oct 06 '25 |
Buy |
17.91 |
256 |
4,585 |
1,307 |
| Parkman Healthcare Partners LL | 10% Owner |
Oct 06 '25 |
Sale |
19.14 |
257 |
4,920 |
1,050 |
1.17%
2.48%
Open in Yahoo
|
Open in Google
|
Open in Finviz
|
Open in MarketWatch
|
Open in EDGAR
|
Open in Reuters
Cap:
|
Volume (24h):