160.07
price down icon11.83%   -22.53
after-market After Hours: 160.00 -0.075 -0.05%
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Spruce Biosciences Inc stock is traded at $160.07, with a volume of 746.43K. It is down -11.83% in the last 24 hours and down -70.37% over the past month. Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The pipeline products of the company include Tralesinidase Alfa (TA-ERT), and Tildacerfont/ Cortibon, a Companion Diagnostic, developed in partnership with HMNC Brain Health.
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Previous Close:
$182.60
Open:
$140
24h Volume:
746.43K
Relative Volume:
1.80
Market Cap:
$90.13M
Revenue:
$7.10M
Net Income/Loss:
$-39.43M
P/E Ratio:
-170.29
EPS:
-0.94
Net Cash Flow:
$-46.50M
1W Performance:
+1,709%
1M Performance:
-70.37%
6M Performance:
-86.69%
1Y Performance:
-90.34%
1-Day Range:
Value
$138.01
$175.00
1-Week Range:
Value
$7.88
$240.00
52-Week Range:
Value
$7.26
$543.38

Spruce Biosciences Inc Stock (SPRB) Company Profile

Name
Name
Spruce Biosciences Inc
Name
Phone
(415) 655-4168
Name
Address
611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Name
Employee
20
Name
Twitter
Name
Next Earnings Date
Name
Latest SEC Filings
Name
SPRB's Discussions on Twitter

Compare SPRB with other stocks

Stocks Price Market Cap Revenue Net Income Cash Flow EPS
Biotechnology icon
SPRB
Spruce Biosciences Inc
160.07 102.81M 7.10M -39.43M -46.50M -0.94
Biotechnology icon
VRTX
Vertex Pharmaceuticals Inc
421.15 105.19B 11.39B 3.64B 3.50B 13.99
Biotechnology icon
ALNY
Alnylam Pharmaceuticals Inc
450.68 60.24B 2.46B -319.09M -52.09M -2.4669
Biotechnology icon
REGN
Regeneron Pharmaceuticals Inc
563.86 61.82B 14.21B 4.46B 3.56B 39.69
Biotechnology icon
ARGX
Argen X Se Adr
798.94 49.09B 3.06B 1.28B 447.35M 19.67
Biotechnology icon
ONC
Beone Medicines Ltd Adr
351.09 37.52B 4.56B -176.77M 225.30M -1.7177

Spruce Biosciences Inc Stock (SPRB) Upgrades & Downgrades

Date Action Analyst Rating Change
Dec-11-24 Downgrade JMP Securities Mkt Outperform → Mkt Perform
Dec-11-24 Downgrade Oppenheimer Outperform → Perform
Mar-14-24 Downgrade Guggenheim Buy → Neutral
Mar-14-24 Downgrade H.C. Wainwright Buy → Neutral
Mar-14-24 Downgrade Ladenburg Thalmann Buy → Neutral
Mar-14-24 Downgrade Leerink Partners Outperform → Market Perform
Mar-14-24 Downgrade RBC Capital Mkts Outperform → Sector Perform
Feb-21-24 Initiated Guggenheim Buy
Dec-17-21 Initiated Oppenheimer Outperform
Dec-10-21 Initiated The Benchmark Company Speculative Buy
Nov-16-21 Downgrade SVB Leerink Outperform → Mkt Perform
Jul-19-21 Initiated H.C. Wainwright Buy
Apr-26-21 Resumed Credit Suisse Outperform
Nov-03-20 Initiated Cowen Outperform
Nov-03-20 Initiated Credit Suisse Outperform
Nov-03-20 Initiated RBC Capital Mkts Outperform
Nov-03-20 Initiated SVB Leerink Outperform
View All

Spruce Biosciences Inc Stock (SPRB) Latest News

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01:42 AM

Spruce Biosciences (SPRB) Secures $50M for Therapy Advancements - GuruFocus

01:42 AM
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01:17 AM

Medical Stocks To ConsiderOctober 6th - MarketBeat

01:17 AM
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09:11 AM

Spruce Biosciences (SPRB) Secures $50M for Enzyme Replacement Therapy - GuruFocus

09:11 AM
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09:06 AM

Spruce Biosciences (SPRB) Secures $50 Million for Enzyme Therapy Development - GuruFocus

09:06 AM
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09:04 AM

Spruce Biosciences secures $50 million in private placement - Investing.com

09:04 AM
pulisher
08:52 AM

Spruce Biosciences (SPRB) Secures $50M in Private Placement for Therapy Advancement - GuruFocus

08:52 AM
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08:20 AM

Spruce Biosciences announces $50.0 million private placement financing - MarketScreener

08:20 AM
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08:00 AM

Spruce Biosciences Announces $50.0 Million Private Placement Financing - Business Wire

08:00 AM
pulisher
06:14 AM

Small Cap Stocks To Follow Today – October 6th - Defense World

06:14 AM
pulisher
Oct 07, 2025

Three Biotech Stocks Jump After Big Regulatory Wins - Finimize

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences Stock: Emergent Surges and Market Implications - timothysykes.com

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences’ Breakthrough: Stock Skyrockets - StocksToTrade

Oct 07, 2025
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Oct 07, 2025

Spruce Biosciences Soars: What’s Driving the Surge? - timothysykes.com

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade) - Seeking Alpha

Oct 07, 2025
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Oct 07, 2025

SPRB Stock Hits 19-Month High Amid Trading Halts - Stocktwits

Oct 07, 2025
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Oct 07, 2025

Spruce Biosciences Stock Surges: Analyzing Breakthrough - StocksToTrade

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences (SPRB) Stock: Rare Disease Breakthrough Sends Shares Soaring Over 1,300% - parameter.io

Oct 07, 2025
pulisher
Oct 07, 2025

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug. - Barron's

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences (SPRB) Skyrockets 1,300% on FDA Breakthrough – Inside the Stock Surge, Pipeline & Outlook (Oct 2025) - ts2.tech

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences (SPRB) Stock Soars 1,378% on FDA Breakthrough Status - MoneyCheck

Oct 07, 2025
pulisher
Oct 07, 2025

Biotech And Tech Stocks Rally On Breakthrough News And Partnerships - Finimize

Oct 07, 2025
pulisher
Oct 07, 2025

Morning Market Movers: GLTO, CISS, SPRB, LXEO See Big Swings - RTTNews

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences Almost Doubles Premarket as FDA Grants Breakthrough Therapy Designation for Tralesinidase Alfa in Sanfilippo Syndrome - MarketScreener

Oct 07, 2025
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Oct 07, 2025

Spruce Biosciences Stock Nearly Doubles Premarket: 'Pharma Bro' Martin Shkreli Sees 280% Upside - Stocktwits

Oct 07, 2025
pulisher
Oct 07, 2025

Why Is Spruce Biosciences Stock (SPRB) Surging Today? - TipRanks

Oct 07, 2025
pulisher
Oct 07, 2025

Spruce Biosciences (SPRB) Stock Jumps 30% After Hours Following Red Hot Rally On Monday: Here's Why - Benzinga

Oct 07, 2025
pulisher
Oct 06, 2025

Small Cap Stocks To Follow TodayOctober 6th - MarketBeat

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences Stock Resumes Trading: What to Expect? - timothysykes.com

Oct 06, 2025
pulisher
Oct 06, 2025

Why This Biotech Stock Just Rocketed Almost 1,400% - Investor's Business Daily

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences Surges on FDA Breakthrough: Is SPRB’s Rally Sustainable? - Azat TV

Oct 06, 2025
pulisher
Oct 06, 2025

Why Spruce Biosciences Just Skyrocketed More Than 1,600% - inkl

Oct 06, 2025
pulisher
Oct 06, 2025

SPRB’s Stock Market Moves: Key Insights​ - StocksToTrade

Oct 06, 2025
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Oct 06, 2025

Spruce Biosciences (SPRB) Surges 1,244% on FDA Breakthrough Ther - GuruFocus

Oct 06, 2025
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Oct 06, 2025

FDA Grants Breakthrough Therapy Status to Spruce Biosciences’ TA-ERT for MPS IIIB - el-balad.com

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Bio jumps after breakthrough therapy status for enzyme replacement therapy - Seeking Alpha

Oct 06, 2025
pulisher
Oct 06, 2025

Promising Pharmaceutical Stocks Worth WatchingOctober 6th - MarketBeat

Oct 06, 2025
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Oct 06, 2025

Spruce Biosciences Skyrockets on FDA Breakthrough – Will SPRB’s Rally Last or Fade? - ts2.tech

Oct 06, 2025
pulisher
Oct 06, 2025

SPRB’s Wild Ride: Understanding Today’s Market Move - timothysykes.com

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences’ Blockchain Breakthrough​ - StocksToTrade

Oct 06, 2025
pulisher
Oct 06, 2025

Nasdaq Jumps Over 150 Points; Skye Bioscience Shares Plunge - Benzinga

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences shares pop after FDA grants Breakthrough Therapy Designation for rare disease treatment - Proactive financial news

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences soars after FDA's 'breakthrough therapy' tag for co's drug - TradingView

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences Stock Is Soaring Today: Here's Why - Benzinga

Oct 06, 2025
pulisher
Oct 06, 2025

Why Did Spruce Biosciences Stock Quadruple Today? - Stocktwits

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences Rockets Sky-High on FDA Breakthrough for Rare Kids’ Brain Therapy - RagingBull

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences (SPRB) Gains FDA Breakthrough Designation for Key Therapy - GuruFocus

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences' TA-ERT Secures FDA's Breakthrough Therapy Designation, Stock Surges - Nasdaq

Oct 06, 2025
pulisher
Oct 06, 2025

FDA grants breakthrough therapy designation to Spruce’s MPS IIIB drug By Investing.com - Investing.com Canada

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences receives U.S. FDA breakthrough therapy designation for Tralesinidase Alfa enzyme replacement therapy in Sanfilippo syndrome type B (MPS IIIB) - MarketScreener

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences stock soars after receiving FDA Breakthrough Therapy status - Investing.com

Oct 06, 2025
pulisher
Oct 06, 2025

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB) - Business Wire

Oct 06, 2025

Spruce Biosciences Inc Stock (SPRB) Financials Data

Revenue

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Net Income

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Cash Flow

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EPS

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$85.37
price down icon 2.02%
$23.34
price up icon 4.76%
$32.74
price up icon 0.34%
$106.31
price up icon 0.23%
$161.81
price down icon 0.30%
biotechnology ONC
$351.09
price up icon 2.77%
Cap:     |  Volume (24h):